Citation: Guru Prasanna Sahoo, Tushar Kanti Rajwar, Jitu Halder, Ajit Mishra, Ritu Mahanty, Ivy Saha, Bibhanwita Satpathy, Rakesh Kumar Sahoo, Deepak Pradhan, Vineet Kumar Rai, Priyanka Dash, Chandan Das, Manoj Kumar Sarangi, Saroj Kumar Rout, Biswakanth Kar, Goutam Ghosh, Goutam Rath. Natural bioactive compounds loaded chitosan nanocarriers: A promising strategy for breast cancer therapy[J]. Chinese Chemical Letters, ;2026, 37(8): 111797. doi: 10.1016/j.cclet.2025.111797 shu

Natural bioactive compounds loaded chitosan nanocarriers: A promising strategy for breast cancer therapy

a.
School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar 751003, India
b.
Amity Institute of Pharmacy, Amity University, Lucknow 201313, India
c.
A&Z Pharmaceutical Inc., Hauppauge, New York 11788, United States

goutamrath123@gmail.com

Received Date: 11 June 2025
Revised Date: 4 September 2025
Accepted Date: 5 September 2025
Available Online: 6 September 2025

Figures(4)

Breast cancer is the most prevalent cancer in women worldwide and a major contributor to cancer-related death. It has been established for decades that natural bioactive compounds are a crucial source for developing novel anticancer drugs. However, their poor targeting, limited solubility and bioavailability, and instability hinder the effectiveness of treatment. With advancements in nanotechnology, nanomedicine delivery systems have emerged as viable approaches to enhance drug bioavailability and therapeutic effectiveness, with natural polymer-based drug carriers gaining significant attention for breast cancer treatment. Chitosan's distinct physicochemical characteristics, biocompatibility, and low immunogenicity make it a popular choice for carrier materials in nanomedicine delivery systems. Their desired qualities include the extent of chemical modification, controlled drug release, surface flexibility, non-toxicity, enhanced stability, cellular uptake, anticancer drug solubility, modulation of release kinetics, and biodistribution. This review aims to illustrate current concerns regarding breast cancer treatment, highlighting the untapped potential of natural bioactive compounds while promoting the latest developments of using chitosan-based nanocarriers to deliver natural bioactive compounds. Finally, this review spotlights the limitations of existing research and the futuristic prospects in this emerging field.
- Breast cancer,
- Chitosan nanocarriers,
- Natural bioactive compounds,
- Controlled release,
- Drug delivery
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沈阳化工大学材料科学与工程学院沈阳 110142