Citation: Yan-Yan Zeng, Jun Jiang, Yan-Cui Wen, Chun-Lin Zhuang, Li-Juan Ou, Zi Yang, Hai-Tao Zhu, Zu-Li Wang, Wei-Min He. Decatungstate-photocatalyzed heterogeneous direct benzylation of N-heterocycles with benzaldehydes[J]. Chinese Chemical Letters, ;2026, 37(4): 111776. doi: 10.1016/j.cclet.2025.111776 shu

Decatungstate-photocatalyzed heterogeneous direct benzylation of N-heterocycles with benzaldehydes

Yan-Yan Zeng ^{a, 1} ,
Jun Jiang ^{a, 1} ,
Yan-Cui Wen ^a ,
Chun-Lin Zhuang ^a ,
Li-Juan Ou ^{b, *,} ,
Zi Yang ^{c, *,} ,
Hai-Tao Zhu ^d ,
Zu-Li Wang ^e ,
Wei-Min He ^{a, *,}

a.
School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China
b.
School of Materials Science and Engineering, Hunan Institute of Technology, Hengyang 421002, China
c.
Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University, Changsha 410219, China
d.
College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China
e.
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

oulijuanann@163.com

yangziycy@163.com

weiminhe@usc.edu.cn

Received Date: 16 January 2025
Revised Date: 28 August 2025
Accepted Date: 30 August 2025
Available Online: 31 August 2025

Figures(6)

The first example of heterogeneous direct benzylation of N-heterocycles (quinoxalin-2(1H)-ones and quinoxalines) with benzaldehydes has been accomplished via the sequence of a NaDT-photocatalyzed HAT, a single electron transfer reduction and a proton transfer, a spin-center shift and a back-HAT. Utilizing this strategy, a diverse array of benzylated N-heterocycles (29 examples) can be produced with high yields. Importantly, the DT-photocatalyzed direct benzylation with benzaldehydes would be a useful complement to the more extensively studied DT-photocatalyzed acylation and hydroxyalkylation, expanding the scope of DT photocatalysis.
- Quinoxalin-2(1H)-ones,
- Benzaldehydes,
- Benzylation,
- Decatungstate,
- Hydrogen atom transfer
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