Citation: Baoqing Liu, Zimeng Li, Xiandong Shi, Jingyi Zhang, Heming Wu, Hailong Liu, Jiahong Zhou. An SCC-9 cell uptake-specific extracellular vesicle drug delivery system for tongue cancer therapy[J]. Chinese Chemical Letters, ;2026, 37(7): 111748. doi: 10.1016/j.cclet.2025.111748 shu

An SCC-9 cell uptake-specific extracellular vesicle drug delivery system for tongue cancer therapy

Baoqing Liu ^a ,
Zimeng Li ^a ,
Xiandong Shi ^a ,
Jingyi Zhang ^a ,
Heming Wu ^{b, *,} ,
Hailong Liu ^{a, *,} ,
Jiahong Zhou ^{a, *,}

a.
College of Life Science, Nanjing Normal University, Nanjing 210023, China
b.
Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China

whmz2002@aliyun.com

lhl7083609@163.com

zhoujiahong@njnu.edu.cn

Received Date: 22 May 2025
Revised Date: 18 August 2025
Accepted Date: 21 August 2025
Available Online: 23 August 2025

Figures(4)

Extracellular vesicles (EVs), mainly comprising microvesicles (MiV) and exosomes (Exo), were successfully isolated from normal human embryonic kidney cells (HEK293T) and demonstrated specific uptake by human tongue squamous cell carcinoma cells (SCC-9). Initial mechanistic investigations revealed that both MiV and Exo were mainly internalized via endocytic pathways and predominantly relied on the surface proteins of SCC-9 cells for specific uptake. Furthermore, Exo, with better stability and uptake efficiency, were chosen as the carriers of the clinical drug cisplatin (CDDP) for the treatment of tongue cancer. Comprehensive in vitro and in vivo evaluations demonstrated that the Exo-CDDP system exhibited remarkable biocompatibility, mitigated drug-related toxicity and minimized CDDP efflux from tumor cells, and displayed potent anti-tumor efficacy. These findings collectively indicated that HEK293T-derived Exo represent a highly promising drug delivery platform for tongue cancer therapy, while simultaneously offering innovative ideas for the development of versatile Exo-based therapeutic delivery systems.
- Extracellular vesicles,
- Microvesicles,
- Exosomes,
- Specific uptake,
- Cisplatin,
- Drug delivery
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沈阳化工大学材料科学与工程学院沈阳 110142