Citation: Kai Zhou, Xinlong He, Yue Liu, Zhongwu Bei, Kun Shi, Danrong Hu, Yilin Wang, Mei Gao, Bingyang Chu, Qian Yang, Chengli Yang, Zhiyong Qian. Advances in injectable hydrogel-based intra-articular treatment systems for osteoarthritis therapy[J]. Chinese Chemical Letters, ;2026, 37(3): 111723. doi: 10.1016/j.cclet.2025.111723 shu

Advances in injectable hydrogel-based intra-articular treatment systems for osteoarthritis therapy

Kai Zhou ^{a, b, 1} ,
Xinlong He ^{c, 1} ,
Yue Liu ^d ,
Zhongwu Bei ^c ,
Kun Shi ^c ,
Danrong Hu ^c ,
Yilin Wang ^e ,
Mei Gao ^e ,
Bingyang Chu ^c ,
Qian Yang ^c ,
Chengli Yang ^f ,
Zhiyong Qian ^{c, *,}

a.
Sports Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China
c.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China
d.
Department of Anesthesiology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China
e.
West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
f.
Department of Pharmacy, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China

zhiyongqian@scu.edu.cn

Received Date: 19 May 2025
Revised Date: 12 August 2025
Accepted Date: 14 August 2025
Available Online: 14 August 2025

Figures(4)

Osteoarthritis (OA), as a multifactorial degenerative joint disorder, is pathologically characterized by structural joint destruction and functional impairment, ultimately leading to chronic locomotor dysfunction. Clinically, intra-articular (IA) injection remains the preferred approach for localized OA treatment due to its advantages of high bioavailability, precise dosing, and minimal systemic side effects. However, frequent IA interventions may induce complications such as patient discomfort, pain, or even infection. Hydrogel materials, with their unique hydrophilic network structures and viscoelastic mechanical properties, are regarded as ideal joint cavity supplements and efficient drug carriers, making them a promising platform for localized therapy. This article systematically reviews recent advances in injectable hydrogel-based OA treatments. First, from a materials science perspective, it comprehensively analyzes the classification of injectable hydrogels (natural/synthetic polymers), their crosslinking mechanisms (chemical/physical/ionic), and environmental responsiveness (temperature/pH/ion triggers). Subsequently, it delves into their therapeutic potential in OA management, covering three major applications: controlled release of small-molecule drugs, cell delivery, and gene therapy. Despite the demonstrated prospects of hydrogels in OA therapy, attributed to their mechanical adaptability, biodegradability, and biocompatibility, key scientific challenges persist, particularly in maintaining IA mechanical homeostasis and long-term structural integrity. The review emphasizes that future research should focus on optimizing hydrogel architectures and enhancing delivery system functionalities to achieve sustained therapeutic efficacy in OA.
- Osteoarthritis,
- Injectable hydrogel,
- Intra-articular,
- Localized therapy,
- Delivery system
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