Citation: Yifei Chen, Yu Wu, Weiqing Xu, Yinjun Tang, Yujia Cai, Wenhong Yang, Wenxuan Jiang, Xin Yu, Jian Li, Ying Zhou, Yiwei Qiu, Wenling Gu, Chengzhou Zhu. Handheld integrated needle sensor based on arginine-engineered Cu-MOF with boosted enzyme-mimicking activity for sensitive detection of glyphosate[J]. Chinese Chemical Letters, ;2026, 37(5): 111649. doi: 10.1016/j.cclet.2025.111649 shu

Handheld integrated needle sensor based on arginine-engineered Cu-MOF with boosted enzyme-mimicking activity for sensitive detection of glyphosate

Yifei Chen ^a ,
Yu Wu ^a ,
Weiqing Xu ^a ,
Yinjun Tang ^a ,
Yujia Cai ^a ,
Wenhong Yang ^a ,
Wenxuan Jiang ^a ,
Xin Yu ^a ,
Jian Li ^a ,
Ying Zhou ^a ,
Yiwei Qiu ^a ,
Wenling Gu ^a ,
Chengzhou Zhu ^{a, b, *,}

a.
State Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China
b.
College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou 311121, China

czzhu@ccnu.edu.cn

Received Date: 17 March 2025
Revised Date: 17 June 2025
Accepted Date: 30 July 2025
Available Online: 7 August 2025

Figures(5)

Metal-organic frameworks (MOFs) with tunable structures provide a versatile platform for exploring active sites and show great potential in enzyme-like catalysis. In this study, arginine was employed as a modulator to synthesize an arginine-copper metal-organic framework (Arg-Cu-MOF), which demonstrated superior peroxidase-like activity and stability in comparison to unmodified Cu-MOF. The improved activity resulted from an increased density of Cu⁺ active sites, facilitating efficient ^•OH generation through H₂O₂ decomposition. Glyphosate interacts with the copper sites in a way that affects ^•OH generation and chromogenic substrate oxidation, leading to detectable colorimetric changes. By integrating Arg-Cu-MOF into a needle sensor, we allowed sample handling, reagent mixing, and signal readout, enabling both precise instrumental measurements and semi-quantitative visual detection of glyphosate. This sensor offers a detection range of 0.05–200 µg/mL with a detection limit of 0.049 µg/mL. This work highlights the potential of MOF modulation strategies and integrated detection platforms to enhance analytical performance, improve user-friendliness, and expand the application scope of biomimetic nanomaterials.
- Enzyme-like catalysis,
- Functional modulator,
- Metal-organic frameworks,
- Sensing,
- Glyphosate
1. [1]
  K. Wang, J. Zhang, Y. Hsu, et al., Chem. Rev. 123 (2023) 5347–5420. doi: 10.1021/acs.chemrev.2c00879
2. [2]
  Y. Wei, M. Zhang, R. Zou, et al., Chem. Rev. 120 (2020) 12089–12174. doi: 10.1021/acs.chemrev.9b00757
3. [3]
  W. Xu, Y. Wu, W. Gu, et al., Chem. Soc. Rev. 53 (2024) 137–162. doi: 10.1039/D3CS00767G
4. [4]
  Y. Xu, A. Huang, W. Yi, et al., Coord. Chem. Rev. 500 (2024) 215517. doi: 10.1016/j.ccr.2023.215517
5. [5]
  X. Li, Z. Wang, J. He, et al., Chem. Sci. 16 (2025) 29–42. doi: 10.1039/D4SC05709K
6. [6]
  J. Chen, Y. Liu, Z. Long, et al., Chin. Chem. Lett. 35 (2024) 109463. doi: 10.1016/j.cclet.2023.109463
7. [7]
  J. Wu, Z. Wang, X. Jin, et al., Adv. Mater. 33 (2021) 2005024. doi: 10.1002/adma.202005024
8. [8]
  M. Adeel, K. Asif, Md. M. Rahman, et al., Adv. Funct. Mater. 31 (2021) 2106023. doi: 10.1002/adfm.202106023
9. [9]
  Y. Chen, Y. Wu, W. Xu, et al., Anal. Chem. 96 (2024) 15231–15237.
10. [10]
  X. Yuan, X. Wu, J. Xiong, et al., Nat. Commun. 14 (2023) 1.
11. [11]
  X. Wang, X. Zhang, Y. Zhao, et al., Angew. Chem. Int. Ed. 62 (2023) e202310367. doi: 10.1002/anie.202310367
12. [12]
  Z. Ye, Y. Jiang, L. Li, et al., eScience 3 (2023) 100107. doi: 10.1016/j.esci.2023.100107
13. [13]
  X. Ma, H. Liu, W. Yang, et al., J. Am. Chem. Soc. 143 (2021) 12220–12229. doi: 10.1021/jacs.1c05032
14. [14]
  M. Gao, L. Li, Z. Sun, et al., Angew. Chem. Int. Ed. 61 (2022) e202211216. doi: 10.1002/anie.202211216
15. [15]
  D. Jiang, C. Huang, J. Zhu, et al., Coord. Chem. Rev. 444 (2021) 214064. doi: 10.1016/j.ccr.2021.214064
16. [16]
  M. Xu, D. Li, K. Sun, et al., Angew. Chem. Int. Ed. 60 (2021) 16372. doi: 10.1002/anie.202104219
17. [17]
  B. Carpenter, A. Talosig, B. Rose, et al., Chem. Soc. Rev. 52 (2023) 6918–6937. doi: 10.1039/d3cs00312d
18. [18]
  T. Chen, H. Xu, S. Li, et al., Adv. Mater. 36 (2024) 2402234. doi: 10.1002/adma.202402234
19. [19]
  W. Zhao, Y. Shi, Y. Jiang, et al., Angew. Chem. Int. Ed. 60 (2021) 5811. doi: 10.1002/anie.202013807
20. [20]
  X. Huang, S. Zhang, Y. Tang, et al., Coord. Chem. Rev. 449 (2021) 214216. doi: 10.1016/j.ccr.2021.214216
21. [21]
  T. Zhao, X. Wang, Z. Sun, et al., Adv. Funct. Mater. 33 (2023) 2303644. doi: 10.1002/adfm.202303644
22. [22]
  T. Tsuruoka, S. Furukawa, Y. Takashima, et al., Angew. Chem. Int. Ed. 48 (2009) 4739. doi: 10.1002/anie.200901177
23. [23]
  C. Atzori, G. Shearer, L. Maschio, et al., J. Phys. Chem. C 121 (2017) 9312–9324. doi: 10.1021/acs.jpcc.7b00483
24. [24]
  E. Bagherzadeh, S. Zebarjad, H. Hosseini, Eur. J. Inorg. Chem. 2018 (2018) 1909–1915. doi: 10.1002/ejic.201800056
25. [25]
  D. Jiang, Y. Zhu, M. Chen, et al., Appl. Catal. B: Environ. Energy 255 (2019) 117746. doi: 10.1016/j.apcatb.2019.117746
26. [26]
  Z. Xu, R. Teng, L. Xu, et al., Adv. Funct. Materials 34 (2024) 2401248. doi: 10.1002/adfm.202401248
27. [27]
  H. Chen, J. Wan, Z. Yan, et al., J. Clean. Prod. 348 (2022) 131367. doi: 10.1016/j.jclepro.2022.131367
28. [28]
  J. Łuczak, M. Kroczewska, M. Baluk, et al., Adv. Colloid Interface Sci. 314 (2023) 102864.
29. [29]
  C. Marshall, E. Timmel, S. Staudhammer, et al., Chem. Sci. 11 (2020) 11539–11547. doi: 10.1039/d0sc04845c
30. [30]
  D. Bara, E. Meekel, I. Pakamore, et al., Mater. Horiz. 8 (2021) 3377–3386. · doi: 10.1039/d1mh01663f
31. [31]
  P. Coliaie, R. Bhawnani, A. Prajapati, et al., Lab Chip 22 (2022) 211–224. doi: 10.1039/d1lc01086g
32. [32]
  T. Rayder, A. Bensalah, B. Li, et al., J. Am. Chem. Soc. 143 (2021) 1630–1640. doi: 10.1021/jacs.0c08957
33. [33]
  H. Liu, L. Chang, C. Bai, et al., Angew. Chem. Int. Ed. 55 (2016) 5019. doi: 10.1002/anie.201511009
34. [34]
  M. Sha, L. Rao, W. Xu, et al., Nano Lett. 23 (2023) 701–709. doi: 10.1021/acs.nanolett.2c04697
35. [35]
  M. Sha, W. Xu, Y. Wu, et al., Sens. Actuators B: Chem. 366 (2022) 131927.
36. [36]
  R. Tuttle, R. Daly, C. Rithner, et al., ACS Appl. Mater. Interfaces 13 (2021) 52006–52013. doi: 10.1021/acsami.1c08917
37. [37]
  L. Fang, Y. Zhang, H. Ding, et al., Adv. Funct. Mater. 34 (2024) 2309338. doi: 10.1002/adfm.202309338
38. [38]
  W. Zhang, D. Sun, B. Yang, et al., Chem. Eng. J. 507 (2025) 160645.
39. [39]
  S. Niu, D. Yue, H. Wang, et al., ACS Appl. Mater. Interfaces 16 (2024) 36295–36303. doi: 10.1021/acsami.4c04853
40. [40]
  C. Wen, S. Yang, J. He, et al., Small 20 (2024) 2405051.
41. [41]
  N. Rathod, S. Mishra, S. Mishra, et al., Chem. Eng. J. 477 (2023) 146765.
42. [42]
  J. Xie, X. He, K. Liu, et al., Sep. Purif. Technol. 351 (2024) 128043.
43. [43]
  W. Zhang, B. Lucier, V. Terskikh, et al., Chem. Sci. 15 (2024) 6690–6706. doi: 10.1039/d4sc00782d
44. [44]
  Y. Fu, Y. Yao, A. Forse, et al., Nat. Commun. 14 (2023) 2386.
45. [45]
  Z. Karimi, B. Karami, M. Farahi, et al., Mater. Today Chem. 38 (2024) 102085.
46. [46]
  W. Xu, N. Hanikel, K. Lomachenko, et al., Angew. Chem. Int. Ed. 62 (2023) e202300003.
47. [47]
  Y. Cai, Y. Wu, Y. Tang, et al., Small 20 (2024) 2403354.
48. [48]
  Y. Wu, Y. Tang, W. Xu, et al., Small 19 (2023) 2302929.
49. [49]
  Y. Yang, C. Tong, R. Zhou, et al., Food Chem. 431 (2024) 137127.
50. [50]
  J. Chang, L. Yu, T. Hou, et al., Anal. Chem. 95 (2023) 4479–4485. doi: 10.1021/acs.analchem.2c05198
51. [51]
  Q. Liu, S. Li, Y. Wang, et al., Sci. Total Environ. 882 (2023) 163548.
52. [52]
  X. Cheng, Y. Xie, G. Li, et al., Inorg. Chem. Front. 10 (2023) 2335–2343. doi: 10.1039/d2qi02727e
53. [53]
  Y. Huang, Z. Li, K. Yao, et al., Appl. Catal. B: Environ. Energy 299 (2021) 120671.
54. [54]
  H. Wang, R. Sun, P. Liu, et al., Nano Res. 17 (2024) 7013–7019. doi: 10.1007/s12274-024-6731-1
55. [55]
  S. Siddiqui, J. Niazi, A. Qureshi, Mater. Today Chem. 22 (2021) 100560.
1. [1]
  Pengfu Gao , Yuan Geng , Wei Gong . Homochiral metal-organic frameworks bearing privileged ligands for heterogeneous asymmetric catalysis. Chinese Journal of Structural Chemistry, 2025, 44(10): 100719-100719. doi: 10.1016/j.cjsc.2025.100719
2. [2]
  Longhao Hu , Lingshan Gong , Wenlong Ye , Hao Chen , Xiao-Li Lai , Yingxiang Ye . Luminescent hydrogen-bonded organic frameworks: From design to applications. Chinese Journal of Structural Chemistry, 2025, 44(11): 100703-100703. doi: 10.1016/j.cjsc.2025.100703
3. [3]
  Deshuai Zhen , Chunlin Liu , Qiuhui Deng , Shaoqi Zhang , Ningman Yuan , Le Li , Yu Liu . A review of covalent organic frameworks for metal ion fluorescence sensing. Chinese Chemical Letters, 2024, 35(8): 109249-. doi: 10.1016/j.cclet.2023.109249
4. [4]
  Chao Liu , Chao Jia , Shi-Xian Gan , Qiao-Yan Qi , Guo-Fang Jiang , Xin Zhao . A luminescent one-dimensional covalent organic framework for organic arsenic sensing in water. Chinese Chemical Letters, 2024, 35(11): 109750-. doi: 10.1016/j.cclet.2024.109750
5. [5]
  Chao Jia , Min Ren , Yingdi Jin , Xingxing Li . Hydrogen migration induced magnetic phase transitions in two-dimensional Fe-porphyrinoid metal-organic frameworks. Chinese Journal of Structural Chemistry, 2026, 45(2): 100801-100801. doi: 10.1016/j.cjsc.2025.100801
6. [6]
  Chengye Lou , Yu Hu , Yunjia Jiang , Lingyao Wang , Yuanbin Zhang . Borane cage hybrid supramolecular metal-organic frameworks (BSFs): Design, synthesis and gas separation performance. Chinese Journal of Structural Chemistry, 2026, 45(2): 100789-100789. doi: 10.1016/j.cjsc.2025.100789
7. [7]
  Yuhao Xiong , Jian Zhang , Yue Sun , Boyuan Hu , Wei Wang , Yuanyuan Yin , Debin Xia , Kaifeng Lin , Yulin Yang , Evgeny Tretyakov . Metal-organic frameworks in perovskite solar cells: Harnessing structural diversity for enhanced photovoltaic performance. Chinese Journal of Structural Chemistry, 2026, 45(3): 100842-100842. doi: 10.1016/j.cjsc.2025.100842
8. [8]
  Jun-Xian Chen , Xian-Xian Xiao , Libo Li , Jinping Li , Rui-Biao Lin , Xiao-Ming Chen . Fine-tuning of Hofmann-type metal-organic frameworks for highly efficient separation of C4 olefins. Chinese Journal of Structural Chemistry, 2025, 44(12): 100744-100744. doi: 10.1016/j.cjsc.2025.100744
9. [9]
  Muhammad Riaz , Rakesh Kumar Gupta , Di Sun , Mohammad Azam , Ping Cui . Selective adsorption of organic dyes and iodine by a two-dimensional cobalt(II) metal-organic framework. Chinese Journal of Structural Chemistry, 2024, 43(12): 100427-100427. doi: 10.1016/j.cjsc.2024.100427
10. [10]
  Xiao-Yu Han , Si-Hua Liu , Su-Yun Zhang , Jian-Ke Sun . Functionally graded materials based on porous poly(ionic liquid)s: Design strategies and applications. Chinese Journal of Structural Chemistry, 2025, 44(7): 100601-100601. doi: 10.1016/j.cjsc.2025.100601
11. [11]
  Tengjia Ni , Xianbiao Hou , Huanlei Wang , Lei Chu , Shuixing Dai , Minghua Huang . Controllable defect engineering based on cobalt metal-organic framework for boosting oxygen evolution reaction. Chinese Journal of Structural Chemistry, 2024, 43(1): 100210-100210. doi: 10.1016/j.cjsc.2023.100210
12. [12]
  Sihong Li , Weiping Deng , Qijie Mo , Haili Song , Chunying Chen , Li Zhang . Engineering S-coordinated Ru single-atoms in a porphyrinic metal-organic framework for CO2 photoreduction. Chinese Journal of Structural Chemistry, 2026, 45(3): 100841-100841. doi: 10.1016/j.cjsc.2025.100841
13. [13]
  Zhiqi Hu , Lingling Wu , Duo Zhang , Yixue An , Jiao Wang , Binbin Zhao , Robert Chunhua Zhao , Rong Cao , Xue Yang . Ultrathin transparent metal-organic framework-based nanocomposite membranes for antibacterial wound healing. Chinese Journal of Structural Chemistry, 2025, 44(12): 100749-100749. doi: 10.1016/j.cjsc.2025.100749
14. [14]
  Mengjin Li , Tian Xia , Mengyu Wang , Yujie Peng , Sihan Zhang , Xueliang Jiang , Huan Yang . Biocarbon-Confined Bimetallic FeCo Metal-Organic Framework Orthogonal Nanosheet Arrays for Industry-level Ethylene Glycol Oxidation. Chinese Journal of Structural Chemistry, 2025, 44(8): 100627-100627. doi: 10.1016/j.cjsc.2025.100627
15. [15]
  Xi Feng , Ding-Yi Hu , Zi-Jun Liang , Mu-Yang Zhou , Zhi-Shuo Wang , Wen-Yu Su , Rui-Biao Lin , Dong-Dong Zhou , Jie-Peng Zhang . A metal azolate framework with small aperture for highly efficient ternary benzene/cyclohexene/cyclohexane separation. Chinese Journal of Structural Chemistry, 2025, 44(3): 100540-100540. doi: 10.1016/j.cjsc.2025.100540
16. [16]
  Ya-Ping Liu , Zhi-Rong Gui , Zhen-Wen Zhang , Sai-Kang Wang , Wei Lang , Yanzhu Liu , Qian-Yong Cao . A phenylphenthiazide anchored Tb(Ⅲ)-cyclen complex for fluorescent turn-on sensing of ClO⁻. Chinese Chemical Letters, 2025, 36(2): 109769-. doi: 10.1016/j.cclet.2024.109769
17. [17]
  Xiao-Hong Yi , Hong-Yu Chu , Chao-Yang Wang , Hang Ren , Li-hong Zhou , Yujie Zhao , Fu-Xue Wang , Hao Du , Yixuan Zhai , Tao Xia , Shaohua Guo , Xiaoning Wang , Yunlong Wang , Qian Wen , Ge Shen , Meng Yang , Yu-Hang Li , Mingjia Xu , Xiaoyuan Zhang , Hao Wang , Xudong Zhao , Yifei Sun , Yi-Lin Liu , Qingyi Zeng , Yuying Deng , Qi Wang , Xiaodong Zhang , Jie Li , Ning Liu , Chuanxi Yang , Jiansheng Li , Anping Wang , Xun Wang , Xuchun Qiu , Haodong Ji , Xuedong Du , Jiaxing Wu , Chong-Chen Wang . Metal-organic frameworks for clean water. Chinese Chemical Letters, 2026, 37(3): 112243-. doi: 10.1016/j.cclet.2025.112243
18. [18]
  Ze Liu , Xiaochen Zhang , Jinlong Luo , Yingjian Yu . Application of metal-organic frameworks to the anode interface in metal batteries. Chinese Chemical Letters, 2024, 35(11): 109500-. doi: 10.1016/j.cclet.2024.109500
19. [19]
  Jiayu Huang , Kuan Chang , Qi Liu , Yameng Xie , Zhijia Song , Zhiping Zheng , Qin Kuang . Fe-N-C nanostick derived from 1D Fe-ZIFs for Electrocatalytic oxygen reduction. Chinese Journal of Structural Chemistry, 2023, 42(10): 100097-100097. doi: 10.1016/j.cjsc.2023.100097
20. [20]
  Chao Wei , Zi-Yi Zhao , Jing-Jing Li , Jinli Zhang , Ming Lu , Xiao-Qin Liu , Guoliang Liu , Jiandong Pang , Lin-Bing Sun . Topology guided construction of MOF by linking Zr-MOLs with perylene diimide motifs for photocatalytic oxidation. Chinese Journal of Structural Chemistry, 2025, 44(8): 100625-100625. doi: 10.1016/j.cjsc.2025.100625

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(15)
HTML views(2)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142