Citation: Xingli Zhang, Peng Xue. Current trends in advanced imaging modalities for the early diagnosis of Alzheimer’s disease[J]. Chinese Chemical Letters, ;2026, 37(3): 111628. doi: 10.1016/j.cclet.2025.111628 shu

Current trends in advanced imaging modalities for the early diagnosis of Alzheimer’s disease

Xingli Zhang ^a ,
Peng Xue ^{a, b, *,}

a.
School of Materials and Energy, Southwest University, Chongqing 400715, China
b.
Yibin Academy of Southwest University, Yibin 644005, China

xuepeng@swu.edu.cn

Received Date: 2 April 2025
Revised Date: 26 June 2025
Accepted Date: 22 July 2025
Available Online: 24 July 2025

Figures(3)

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by complex pathological features such as amyloid-β plaques and tau tangles. Early and accurate diagnosis is crucial for effective intervention, yet remains challenging. This review focuses on current and emerging imaging modalities used in AD detection, including positron emission tomography, single-photon emission computed tomography, magnetic resonance imaging (MRI), fluorescence imaging, photoacoustic imaging, and mass spectrometry imaging, with an emphasis on their mechanisms, advantages, and limitations. Special attention is given to the integration of nanotechnology with imaging platforms, highlighting how nanomaterials enhance diagnostic specificity, sensitivity, stability and therapeutic potential. The review also explores recent advances in multimodal imaging, artificial intelligence-assisted diagnostics, and future directions toward personalized and other non-invasive strategies for early AD diagnosis.
- Alzheimer’s disease,
- Imaging technologies,
- Nanotechnology,
- Diagnosis,
- Theranostics
1. [1]
  H.T. Beier, C.B. Cowan, I.H. Chou, et al., Plasmonics 2 (2007) 55–64. doi: 10.1007/s11468-007-9027-x
2. [2]
  T. Demeritte, B.P. Viraka Nellore, R. Kanchanapally, et al., ACS Appl. Mater. Interfaces 7 (2015) 13693–13700. doi: 10.1021/acsami.5b03619
3. [3]
  M. Hadjidemetriou, J. Rivers-Auty, L. Papafilippou, et al., ACS Nano 15 (2021) 7357–7369. doi: 10.1021/acsnano.1c00658
4. [4]
  G. Eskici, P.H. Axelsen, Biochemistry 51 (2012) 6289–6311. doi: 10.1021/bi3006169
5. [5]
  S.J. Yang, J.U. Lee, M.J. Jeon, S.J. Sim, Anal. Chim. Acta 1195 (2022) 339445. doi: 10.1016/j.aca.2022.339445
6. [6]
  I.H. Chou, M. Benford, H.T. Beier, et al., Nano Lett. 8 (2008) 1729–1735. doi: 10.1021/nl0808132
7. [7]
  K.H.P. Vu, M.C. Lee, G.H. Blankenburg, et al., Anal. Chem. 93 (2021) 16320–16329. doi: 10.1021/acs.analchem.1c01521
8. [8]
  H. Gao, J. Wang, J. Liu, et al., ACS Chem. Neurosci. 12 (2021) 4257–4264. doi: 10.1021/acschemneuro.1c00613
9. [9]
  Y. Zhou, Z. Song, X. Han, H. Li, X. Tang, ACS Chem. Neurosci. 12 (2021) 4209. doi: 10.1021/acschemneuro.1c00472
10. [10]
  S. Teipel, A. Drzezga, M.J. Grothe, et al., Lancet Neurol. 14 (2015) 1037–1053. doi: 10.1016/S1474-4422(15)00093-9
11. [11]
  A. Zengin, U. Tamer, T. Caykara, Biomacromolecules 14 (2013) 3001–3009. doi: 10.1021/bm400968x
12. [12]
  S.X. Zhou, H. Zhou, P.J. Walian, B.K. Jap, Biochemistry 46 (2007) 2553–2563. doi: 10.1021/bi602509c
13. [13]
  M.M. Gessel, S. Bernstein, M. Kemper, D.B. Teplow, M.T. Bowers, ACS Chem. Neurosci. 3 (2012) 909–918. doi: 10.1021/cn300050d
14. [14]
  N. Puentes-Díaz, D. Chaparro, D. Morales-Morales, A. Flores-Gaspar, J. Alí-Torres, ACS Omega 8 (2023) 4508–4526. doi: 10.1021/acsomega.2c06939
15. [15]
  P. Paudel, S.H. Seong, Y. Zhou, et al., ACS Omega 4 (2019) 12259–12270. doi: 10.1021/acsomega.9b01557
16. [16]
  J. Kiskis, H. Fink, L. Nyberg, et al., Sci. Rep. 5 (2015) 13489. doi: 10.1038/srep13489
17. [17]
  H. Rai, S. Gupta, S. Kumar, et al., J. Med. Chem. 65 (2022) 8550–8595. doi: 10.1021/acs.jmedchem.1c01619
18. [18]
  F. Gao, Eur. J. Radiol. 145 (2021) 110017. doi: 10.1016/j.ejrad.2021.110017
19. [19]
  E.C.B. Johnson, E.B. Dammer, D.M. Duong, et al., Nat. Med. 26 (2020) 769–780. doi: 10.1038/s41591-020-0815-6
20. [20]
  G. Biechele, B.S. Rauchmann, D. Janowitz, et al., J. Neuroinflamm. 21 (2024) 30. doi: 10.1186/s12974-024-03020-y
21. [21]
  G.D. Stanciu, A. Luca, R.N. Rusu, et al., Biomolecules 10 (2019) 40. doi: 10.3390/biom10010040
22. [22]
  M. Padurariu, A. Ciobica, R. Lefter, et al., Psychiatr. Danub. 25 (2013) 401–409.
23. [23]
  L. Tillement, L. Lecanu, V. Papadopoulos, Mitochondrion 11 (2011) 13–21. doi: 10.1016/j.mito.2010.08.009
24. [24]
  Y. Liu, M. Nguyen, A. Robert, B. Meunier, Acc. Chem. Res. 52 (2019) 2026–2035. doi: 10.1021/acs.accounts.9b00248
25. [25]
  A.T. Kodamullil, F. Zekri, M. Sood, et al., Nat. Rev. Drug Discov. 16 (2017) 819. doi: 10.1038/nrd.2017.169
26. [26]
  Z. Liu, Q. Liu, B. Zhang, et al., J. Med. Chem. 64 (2021) 13853–13872. doi: 10.1021/acs.jmedchem.1c01240
27. [27]
  P. Dao, F. Ye, Y. Liu, et al., ACS Chem. Neurosci. 8 (2017) 798–806. doi: 10.1021/acschemneuro.6b00380
28. [28]
  A. Robert, Y. Liu, M. Nguyen, B. Meunier, Acc. Chem. Res. 48 (2015) 1332–1339. doi: 10.1021/acs.accounts.5b00119
29. [29]
  J. Cai, P. Yi, Y. Miao, et al., ACS Appl. Mater. Interfaces 12 (2020) 26812–26821. doi: 10.1021/acsami.0c01597
30. [30]
  Y. Li, E. Lim, T. Fields, et al., ACS Biomater. Sci. Eng. 5 (2019) 3595–3605. doi: 10.1021/acsbiomaterials.9b00086
31. [31]
  A. Nandakumar, Y. Xing, R.R. Aranha, et al., Biomacromolecules 21 (2020) 988–998. doi: 10.1021/acs.biomac.9b01650
32. [32]
  F. Bisceglia, F. Seghetti, M. Serra, et al., ACS Chem. Neurosci. 10 (2018) 1420–1433.
33. [33]
  Y. Yang, D. Arseni, W. Zhang, et al., Science 375 (2022) 167–172. doi: 10.1126/science.abm7285
34. [34]
  Y.W. Jun, S.W. Cho, J. Jung, et al., ACS Cent. Sci. 5 (2019) 209–217. doi: 10.1021/acscentsci.8b00951
35. [35]
  M.G. Savelieff, S. Lee, Y. Liu, M.H. Lim, ACS Chem. Biol. 8 (2013) 856–865. doi: 10.1021/cb400080f
36. [36]
  F. Peccati, S. Pantaleone, V. Riffet, et al., J. Phys. Chem. B 121 (2017) 8926–8934. doi: 10.1021/acs.jpcb.7b06675
37. [37]
  S.S. More, R. Vince, ACS Chem. Neurosci. 6 (2014) 306–315.
38. [38]
  W. Zhen, H. Han, M. Anguiano, et al., J. Med. Chem. 42 (1999) 2805–2815. doi: 10.1021/jm990103w
39. [39]
  C. Duyckaerts, B. Delatour, M.C. Potier, Acta Neuropathol. 118 (2009) 5–36. doi: 10.1007/s00401-009-0532-1
40. [40]
  E.K. Agyare, S.R. Leonard, G.L. Curran, et al., Mol. Pharm. 10 (2013) 1557–1565. doi: 10.1021/mp300352c
41. [41]
  S.S. More, A.P. Vartak, R. Vince, ACS Chem. Neurosci. 4 (2012) 330–338.
42. [42]
  H. Chen, S. Liu, S. Li, et al., ACS Chem. Neurosci. 9 (2018) 1560–1565. doi: 10.1021/acschemneuro.8b00003
43. [43]
  L. Zhu, L. Xu, X. Wu, et al., ACS Appl. Mater. Interfaces 13 (2021) 23328–23338. doi: 10.1021/acsami.1c00257
44. [44]
  Y. Miller, B. Ma, R. Nussinov, Biochemistry 50 (2011) 5172–5181. doi: 10.1021/bi200400u
45. [45]
  D. Chu, F. Liu, ACS Chem. Neurosci. 10 (2018) 931–944.
46. [46]
  M. Sadqi, F. Hernández, U. Pan, et al., Biochemistry 41 (2002) 7150–7155. doi: 10.1021/bi025777e
47. [47]
  B. Pan, X. Lu, X. Han, et al., ACS Omega 6 (2021) 31782–31796. doi: 10.1021/acsomega.1c04434
48. [48]
  H.Y. Qureshi, T. Li, R. MacDonald, et al., Biochemistry 52 (2013) 6445–6455. doi: 10.1021/bi400442d
49. [49]
  M.D.C. Cárdenas-Aguayo, L. Gómez-Virgilio, S. DeRosa, M.A. Meraz-Ríos, ACS Chem. Neurosci. 5 (2014) 1178–1191. doi: 10.1021/cn500148z
50. [50]
  S. Ahmadi, S. Zhu, R. Sharma, et al., ACS Omega 4 (2019) 5356–5366. doi: 10.1021/acsomega.8b03595
51. [51]
  A. Soragni, B. Zambelli, M.D. Mukrasch, et al., Biochemistry 47 (2008) 10841–10851. doi: 10.1021/bi8008856
52. [52]
  D. Yugay, D.P. Goronzy, L.M. Kawakami, et al., Nano Lett. 16 (2016) 6282–6289. doi: 10.1021/acs.nanolett.6b02590
53. [53]
  C. Ghosh, M. Seal, S. Mukherjee, S.G. Dey, Acc. Chem. Res. 48 (2015) 2556–2564. doi: 10.1021/acs.accounts.5b00102
54. [54]
  C. Ghosh, D. Pramanik, S. Mukherjee, A. Dey, S.G. Dey, Inorg. Chem. 52 (2012) 362–368.
55. [55]
  L. Lai, C. Zhao, M. Su, et al., Biomater. Sci. 4 (2016) 1085–1091. doi: 10.1039/C6BM00233A
56. [56]
  E. Akyuz, A. Arulsamy, F.S. Aslan, et al., Mol. Neurobiol. 62 (2025) 1631–1674. doi: 10.1007/s12035-024-04333-y
57. [57]
  S. He, X. Zhang, S. Qu, ACS Chem. Neurosci. 10 (2018) 175–181.
58. [58]
  A. Sánchez-Melgar, J.L. Albasanz, M. Pallàs, M. Martín, ACS Chem. Neurosci. 11 (2020) 1770–1780. doi: 10.1021/acschemneuro.0c00067
59. [59]
  J.L. Albasanz, E. Dalfó, I. Ferrer, M. Martín, Neurobiol. Dis. 20 (2005) 685–693. doi: 10.1016/j.nbd.2005.05.001
60. [60]
  M. Renner, P.N. Lacor, P.T. Velasco, et al., Neuron 66 (2010) 739–754. doi: 10.1016/j.neuron.2010.04.029
61. [61]
  R. Jarosova, S.S. Niyangoda, P. Hettiarachchi, M.A. Johnson, ACS Chem. Neurosci. 13 (2022) 2924–2931. doi: 10.1021/acschemneuro.2c00484
62. [62]
  Y. Yang, L. Zhang, J. Wang, et al., Anal. Chem. 94 (2022) 13498–13506. doi: 10.1021/acs.analchem.2c02627
63. [63]
  J. del Pino, J. Marco-Contelles, F. López-Muñoz, A. Romero, E. Ramos, ACS Chem. Neurosci. 9 (2018) 2880–2885. doi: 10.1021/acschemneuro.8b00203
64. [64]
  J. Frandsen, S.R. Choi, P. Narayanasamy, ACS Chem. Neurosci. 11 (2020) 356–366. doi: 10.1021/acschemneuro.9b00566
65. [65]
  S. Mondal, Y. Vashi, P. Ghosh, et al., ACS Chem. Neurosci. 11 (2020) 3277–3287. doi: 10.1021/acschemneuro.0c00387
66. [66]
  H.J. Kwon, M.Y. Cha, D. Kim, et al., ACS Nano 10 (2016) 2860–2870. doi: 10.1021/acsnano.5b08045
67. [67]
  M.P. Singulani, C.P.M. Pereira, A.F.F. Ferreira, et al., Exp. Gerontol. 133 (2020) 110882. doi: 10.1016/j.exger.2020.110882
68. [68]
  R. Tao, M. Liao, Y. Wang, et al., Anal. Chem. 94 (2021) 1308–1317.
69. [69]
  A.C. Leskovjan, A. Kretlow, L.M. Miller, Anal. Chem. 82 (2010) 2711–2716. doi: 10.1021/ac1002728
70. [70]
  J.H. Park, W. Sun, M. Cui, Proc. Natl. Acad. Sci. 112 (2015) 9236–9241. doi: 10.1073/pnas.1505939112
71. [71]
  V.P.B. Grover, J.M. Tognarelli, M.M.E. Crossey, et al., J. Clin. Exp. Hepatol. 5 (2015) 246–255. doi: 10.1016/j.jceh.2015.08.001
72. [72]
  T. Fernández, A. Martínez-Serrano, L. Cussó, M. Desco, M. Ramos-Gómez, ACS Chem. Neurosci. 9 (2018) 912–924. doi: 10.1021/acschemneuro.7b00260
73. [73]
  L. Chen, Z. Wei, K.W.Y. Chan, et al., Neuroimage 188 (2019) 380–390. doi: 10.1016/j.neuroimage.2018.12.018
74. [74]
  J. Liu, C. Chen, H. Chen, et al., Anal. Chem. 94 (2022) 16213–16221. doi: 10.1021/acs.analchem.2c03765
75. [75]
  H. Takahashi, K. Ishii, N. Kashiwagi, et al., Clin. Radiol. 72 (2017) 108–115. doi: 10.1016/j.crad.2016.11.002
76. [76]
  T. Prasath, V. Sumathi, Int. J. Environ. Res. Public Health 20 (2023) 1273. doi: 10.3390/ijerph20021273
77. [77]
  M.B. Hulkower, D.B. Poliak, S.B. Rosenbaum, M.E. Zimmerman, M.L. Lipton, Am. J. Neuroradiol. 34 (2013) 2064–2074. doi: 10.3174/ajnr.A3395
78. [78]
  N.A. Johnson, G.H. Jahng, M.W. Weiner, et al., Radiology 234 (2005) 851–859. doi: 10.1148/radiol.2343040197
79. [79]
  H.Y.A. Mhanna, A.F. Omar, Y.M. Radzi, et al., Heliyon 11 (2025) e42464. doi: 10.1016/j.heliyon.2025.e42464.3390/su142416732
80. [80]
  V. Kotoula, J.W. Evans, C.E. Punturieri, C.A. Zarate, Front. Neuroimaging 2 (2023) 1110258. doi: 10.3389/fnimg.2023.1110258
81. [81]
  J.M. Soares, R. Magalhães, P.S. Moreira, et al., Front. Neurosci. 10 (2016) 515.
82. [82]
  P. Ren, M. Ma, G. Xie, Z. Wu, D. Wu, Aging 12 (2020) 13571–13582. doi: 10.18632/aging.103463
83. [83]
  C. Li, M. Liu, J. Xia, et al., IEEE J. Biomed. Health Inform. 27 (2023) 5430–5438. doi: 10.1109/JBHI.2023.3306460
84. [84]
  N. Falgàs, M. Peña-González, A. Val-Guardiola, et al., Alzheimer’s Dement. 20 (2024) 6351–6364. doi: 10.1002/alz.14131
85. [85]
  S. Ruiz, S. Lee, S.R. Soekadar, et al., Hum. Brain Mapp. 34 (2013) 200–212. doi: 10.1002/hbm.21427
86. [86]
  M. Mitolo, M. Stanzani-Maserati, S. Capellari, et al., Neuroimage Clin. 23 (2019) 101843. doi: 10.1016/j.nicl.2019.101843
87. [87]
  P. Chen, Z. Shen, Q. Wang, et al., Front. Aging Neurosci. 13 (2021) 618690. doi: 10.3389/fnagi.2021.618690
88. [88]
  X. Xu, J. Xu, K.W.Y. Chan, et al., Magn. Reson. Med. 81 (2018) 47–56.
89. [89]
  L. Xu, L. Lai, Y. Wen, et al., ACS Chem. Neurosci. 14 (2023) 226–234. doi: 10.1021/acschemneuro.2c00513
90. [90]
  C.C. Yang, S.Y. Yang, J.J. Chieh, et al., ACS Chem. Neurosci. 2 (2011) 500–505. doi: 10.1021/cn200028j
91. [91]
  H. Skaat, S. Margel, Biochem. Biophys. Res. Commun. 386 (2009) 645–649. doi: 10.1016/j.bbrc.2009.06.110
92. [92]
  A.F. Martins, J.F. Morfin, A. Kubícková, et al., ACS Med. Chem. Lett. 4 (2013) ˇ 436–440. doi: 10.1021/ml400042w
93. [93]
  Y. Lin, K. Huang, H. Xu, et al., Clin. Neurophysiol. 131 (2020) 2429–2439. doi: 10.1016/j.clinph.2020.07.016
94. [94]
  A. Rubinski, N. Franzmeier, J. Neitzel, M. Ewers, Alzheimer’s Res. Ther. 12 (2020) 133. doi: 10.1186/s13195-020-00702-6
95. [95]
  J.L. Whitwell, J. Graff-Radford, N. Tosakulwong, et al., Alzheimer’s, Dementia 14 (2018) 1005–1014.
96. [96]
  A. Touroutoglou, Y. Katsumi, M. Brickhouse, et al., Alzheimer’s Dement. 19 (2023) S74–S88.
97. [97]
  D. Jin, B. Zhou, Y. Han, et al., Adv. Sci. 7 (2020) 2000675. doi: 10.1002/advs.202000675
98. [98]
  A. Ortiz, J.M. Górriz, J. Ramírez, F.J. Martínez-Murcia, Pattern Recognit. Lett. 34 (2013) 1725–1733. doi: 10.1016/j.patrec.2013.04.014
99. [99]
  Q. Zhang, J. Sheng, Q. Zhang, et al., Comput. Biol. Med. 165 (2023) 107392. doi: 10.1016/j.compbiomed.2023.107392
100. [100]
  G. Cao, M. Zhang, Y. Wang, et al., Comput. Biol. Med. 163 (2023) 107110. doi: 10.1016/j.compbiomed.2023.107110
101. [101]
  V. Sanjay, P. Swarnalatha, Alex. Eng. J. 104 (2024) 451–463. doi: 10.1016/j.aej.2024.07.123
102. [102]
  R. Sampath, M. Baskar, J. Prev, Alzheimer’s Dis. 11 (2024) 1106–1121.
103. [103]
  X. Gao, H. Liu, F. Shi, D. Shen, M. Liu, IEEE J. Biomed. Health Inform. 27 (2023) 4961–4970. doi: 10.1109/JBHI.2023.3304388
104. [104]
  H. Cai, Q. Zhang, Y. Long, Comput. Biol. Med. 154 (2023) 106570. doi: 10.1016/j.compbiomed.2023.106570
105. [105]
  C.D. Mayo, M.A. Garcia-Barrera, E.L. Mazerolle, et al., Front. Aging Neurosci. 10 (2019) 436. doi: 10.3389/fnagi.2018.00436
106. [106]
  N. Shu, Y. Liang, H. Li, J. Zhang, et al., Radiology 265 (2012) 518–527. doi: 10.1148/radiol.12112361
107. [107]
  H.K.F. Mak, W. Qian, K.S. Ng, et al., J. Alzheimer’s Dis. 41 (2014) 749–758. doi: 10.3233/JAD-131868
108. [108]
  E.T. Petersen, T. Lim, X. Golay, Magn. Reson. Med. 55 (2006) 219–232. doi: 10.1002/mrm.20784
109. [109]
  M.I.S.S. Agnollitto, R.F. Leoni, M.P. Foss, et al., Dement. Neuropsychol. 25 (2023) e20230004.
110. [110]
  N. Zhang, M.L. Gordon, T.E. Goldberg, Neurosci. Biobehav. Rev. 72 (2017) 168–175. doi: 10.1016/j.neubiorev.2016.11.023
111. [111]
  T. Dashjamts, T. Yoshiura, A. Hiwatashi, et al., Acad. Radiol. 18 (2011) 1492–1499. doi: 10.1016/j.acra.2011.07.015
112. [112]
  H.F. Kung, S.R. Choi, W. Qu, W. Zhang, D. Skovronsky, J. Med. Chem. 53 (2009) 933–941.
113. [113]
  K. Terpstra, Y. Wang, T.T. Huynh, et al., Inorg. Chem. 61 (2022) 20326–20336. doi: 10.1021/acs.inorgchem.2c02740
114. [114]
  M.V. Fawaz, A.F. Brooks, M.E. Rodnick, et al., ACS Chem. Neurosci. 5 (2014) 718–730. doi: 10.1021/cn500103u
115. [115]
  K. Matsumura, M. Ono, H. Kimura, et al., ACS Med. Chem. Lett. 3 (2011) 58–62.
116. [116]
  Y. Okumura, Y. Maya, T. Onishi, et al., ACS Chem. Neurosci. 9 (2018) 1503–1514. doi: 10.1021/acschemneuro.8b00064
117. [117]
  K. Serdons, C. Terwinghe, P. Vermaelen, et al., J. Med. Chem. 52 (2009) 1428–1437. doi: 10.1021/jm8013376
118. [118]
  T.J. Betthauser, K.A. Cody, M.D. Zammit, et al., J. Nucl. Med. 60 (2019) 93–99. doi: 10.2967/jnumed.118.209650
119. [119]
  S. Sanabria Bohórquez, J. Marik, A. Ogasawara, et al., Eur. J. Nucl. Med. Mol. Imaging 46 (2019) 2077–2089. doi: 10.1007/s00259-019-04399-0
120. [120]
  N. Lazarova, S.S. Zoghbi, J. Hong, et al., J. Med. Chem. 51 (2008) 6034–6043. doi: 10.1021/jm800510m
121. [121]
  W. Zheng, Y. Huang, H. Chen, et al., ACS Chem. Neurosci. 14 (2023) 988–1003. doi: 10.1021/acschemneuro.3c00025
122. [122]
  A. Mueller, S. Bullich, O. Barret, et al., J. Nucl. Med. 61 (2020) 911–919. doi: 10.2967/jnumed.119.236224
123. [123]
  D.T. Chien, S. Bahri, A.K. Szardenings, et al., J. Alzheimer’s Dis. 34 (2013) 457–468. doi: 10.3233/JAD-122059
124. [124]
  A.S. Fleisher, M.J. Pontecorvo, M.D. Devous, et al., JAMA Neurol. 77 (2020) 829–839. doi: 10.1001/jamaneurol.2020.0528
125. [125]
  J. Dronse, K. Fliessbach, G.N. Bischof, et al., J. Alzheimer’s Dis. 55 (2016) 465–471. doi: 10.3233/JAD-160316
126. [126]
  H. Kuwabara, R.A. Comley, E. Borroni, et al., J. Nucl. Med. 59 (2018) 1877–1884. doi: 10.2967/jnumed.118.214437
127. [127]
  M.S. Goyal, T. Blazey, N.V. Metcalf, et al., Proc. Natl. Acad. Sci. U. S. A. 120 (2023) e2212256120. doi: 10.1073/pnas.2212256120
128. [128]
  A. Wabik, E. Trypka, J. Bladowska, et al., J. Transl. Med. 20 (2022) 259. doi: 10.1186/s12967-022-03464-x
129. [129]
  X. Pan, M. Adel, C. Fossati, et al., Comput. Methods Programs Biomed. 180 (2019) 105027. doi: 10.1016/j.cmpb.2019.105027
130. [130]
  D. Sehlin, X.T. Fang, L. Cato, et al., Nat. Commun. 7 (2016) 10759. doi: 10.1038/ncomms10759
131. [131]
  S.R. Meier, S. Syvänen, G. Hultqvist, et al., J. Nucl. Med. 59 (2018) 1885–1891. doi: 10.2967/jnumed.118.213140
132. [132]
  S. Syvänen, J. Eriksson, ACS Chem. Neurosci. 4 (2012) 225–237.
133. [133]
  L.E. McInnes, A. Noor, K. Kysenius, et al., Inorg. Chem. 58 (2019) 3382–3395. doi: 10.1021/acs.inorgchem.8b03466
134. [134]
  N. Sheikh-Bahaei, S.A. Sajjadi, R. Manavaki, et al., Ann. Neurol. 83 (2018) 771–778. doi: 10.1002/ana.25202
135. [135]
  Z. Li, M. Cui, J. Dai, et al., J. Med. Chem. 56 (2013) 471–482. doi: 10.1021/jm3014184
136. [136]
  X. Zhang, P. Yu, Y. Yang, et al., Bioconjug. Chem. 27 (2016) 2493–2504. doi: 10.1021/acs.bioconjchem.6b00444
137. [137]
  B. Spyrou, I.N. Hungnes, F. Mota, et al., Inorg. Chem. 60 (2021) 13669–13680. doi: 10.1021/acs.inorgchem.1c01992
138. [138]
  M. Sagnou, B. Mavroidi, A. Shegani, et al., J. Med. Chem. 62 (2019) 2638–2650. doi: 10.1021/acs.jmedchem.8b01949
139. [139]
  X. Zhang, Y. Hou, C. Peng, et al., J. Med. Chem. 61 (2018) 1330–1339. doi: 10.1021/acs.jmedchem.7b01834
140. [140]
  Y. Maya, M. Ono, H. Watanabe, et al., Bioconjug. Chem. 20 (2009) 95–101. doi: 10.1021/bc8003292
141. [141]
  E. Schlein, S. Syvänen, J. Rokka, et al., Mol. Biopharm. 19 (2022) 4111–4122. doi: 10.1021/acs.molpharmaceut.2c00536
142. [142]
  H. Watanabe, T. Kishimoto, S. Kaide, et al., ACS Med. Chem. Lett. 12 (2021) 805–811. doi: 10.1021/acsmedchemlett.1c00071
143. [143]
  M. Takahashi, T. Tada, T. Nakamura, K. Koyama, T. Momose, Am. J. Alzheimer’s Dis. Other Dement. 34 (2019) 314–321. doi: 10.1177/1533317519841192
144. [144]
  Y. Höller, A.C. Bathke, A. Uhl, et al., Front. Aging Neurosci. 9 (2017) 290. doi: 10.3389/fnagi.2017.00290
145. [145]
  Y.C. Ni, F.P. Tseng, M.C. Pai, et al., Diagnostics 11 (2021) 2091. doi: 10.3390/diagnostics11112091
146. [146]
  F.P.M. Oliveira, Z. Walker, R.W.H. Walker, et al., J. Neurol. Neurosurg. Psychiatry 92 (2021) 662–667. doi: 10.1136/jnnp-2020-324606
147. [147]
  R. Ni, A. Villois, X.L. Dean-Ben, et al., Photoacoustics 23 (2021) 100285. doi: 10.1016/j.pacs.2021.100285
148. [148]
  S.S. Shin, T.A.G.M. Huisman, M. Hwang, J. Ultrasound Med. 37 (2018) 1857–1867. doi: 10.1002/jum.14547
149. [149]
  Y.J. Ho, C.C. Huang, C.H. Fan, et al., Cell. Mol. Life Sci. 78 (2021) 6119–6141. doi: 10.1007/s00018-021-03904-9
150. [150]
  R. Liu, J. Tang, Y. Xu, Z. Dai, ACS Nano 13 (2019) 5124–5132. doi: 10.1021/acsnano.8b08359
151. [151]
  C. Morisset, A. Dizeux, B. Larrat, et al., Sci. Rep. 12 (2022) 19515. doi: 10.1038/s41598-022-23366-8
152. [152]
  W. Wang, X. Wu, K.W. Kevin Tang, et al., J. Am. Chem. Soc. 145 (2023) 1097–1107. doi: 10.1021/jacs.2c10666
153. [153]
  E.P. Hackett, B.R. Shah, B. Cheng, et al., ACS Chem. Neurosci. 12 (2021) 2820–2828. doi: 10.1021/acschemneuro.1c00197
154. [154]
  B. Ling, J. Lee, D. Maresca, et al., ACS Nano 14 (2020) 12210–12221. doi: 10.1021/acsnano.0c05912
155. [155]
  H. Huang, P.L. Hsu, S.F. Tsai, et al., Adv. Sci. 10 (2023) 2302345. doi: 10.1002/advs.202302345
156. [156]
  H.C. Li, P.Y. Chen, H.F. Cheng, Y.M. Kuo, C.C. Huang, IEEE Trans. Biomed. Eng. 66 (2019) 3393–3401. doi: 10.1109/TBME.2019.2904702
157. [157]
  S. Wang, Z. Li, Y. Liu, et al., Sens. Actuators B 267 (2018) 403–411. doi: 10.1016/j.snb.2018.04.052
158. [158]
  H. Li, P. Zhang, L.P. Smaga, R.A. Hoffman, J. Chan, J. Am. Chem. Soc. 137 (2015) 15628–15631. doi: 10.1021/jacs.5b10504
159. [159]
  J. Zhang, X. Zhen, P.K. Upputuri, et al., Adv. Mater. 29 (2017) 1604764. doi: 10.1002/adma.201604764
160. [160]
  S. Wang, G. Yu, Y. Ma, et al., ACS Appl. Mater. Interfaces 11 (2018) 1917–1923.
161. [161]
  Y. Han, H. Yi, Y. Wang, et al., ACS Nano 16 (2022) 19053–19066. doi: 10.1021/acsnano.2c08094
162. [162]
  Z. Jiang, Z. Liang, Y. Cui, et al., J. Am. Chem. Soc. 145 (2023) 7952–7961. doi: 10.1021/jacs.2c13315
163. [163]
  T. Guo, K. Xiong, B. Yuan, et al., Photoacoustics 31 (2023) 100516. doi: 10.1016/j.pacs.2023.100516
164. [164]
  S. Wang, Z. Sheng, Z. Yang, et al., Angew. Chem. Int. Ed. 58 (2019) 12415–12419. doi: 10.1002/anie.201904047
165. [165]
  S. Na, J.J. Russin, L. Lin, et al., Nat. Biomed. Eng. 6 (2022) 584–592.
166. [166]
  X. Wang, Y. Pang, G. Ku, et al., Nat. Biotechnol. 21 (2003) 803. doi: 10.1038/nbt839
167. [167]
  R.P.Y. Chen, M.G. Soliman, H.A. Davies, et al., PLoS ONE 17 (2022) e0259608. doi: 10.1371/journal.pone.0259608
168. [168]
  D. Razansky, J. Klohs, R. Ni, Eur. J. Nucl. Med. Mol. Imaging 48 (2021) 4152–4170. doi: 10.1007/s00259-021-05207-4
169. [169]
  P. Vagenknecht, A. Luzgin, M. Ono, et al., Eur. J. Nucl. Med. Mol. Imaging 49 (2022) 2137–2152. doi: 10.1007/s00259-022-05708-w
170. [170]
  S. Jo, I.C. Sun, C.H. Ahn, S. Lee, K. Kim, ACS Appl. Mater. Interfaces 15 (2022) 120–137.
171. [171]
  C. Li, G. Chen, Y. Zhang, F. Wu, Q. Wang, J. Am. Chem. Soc. 142 (2020) 14789–14804. doi: 10.1021/jacs.0c07022
172. [172]
  S. Wang, H. Shi, L. Wang, et al., J. Am. Chem. Soc. 144 (2022) 23668–23676. doi: 10.1021/jacs.2c11223
173. [173]
  Z. Sheng, B. Guo, D. Hu, et al., Adv. Mater. 30 (2018) 1800766. doi: 10.1002/adma.201800766
174. [174]
  M. Cui, M. Ono, H. Watanabe, et al., J. Am. Chem. Soc. 136 (2014) 3388–3394. doi: 10.1021/ja4052922
175. [175]
  Y. Ge, F. Zeng, G. Sun, et al., ACS Chem. Neurosci. 12 (2021) 3683–3689. doi: 10.1021/acschemneuro.1c00419
176. [176]
  K. Zhou, Y. Li, Y. Peng, et al., Anal. Chem. 90 (2018) 8576–8582. doi: 10.1021/acs.analchem.8b01712
177. [177]
  C. Li, L. Cao, Y. Zhang, et al., Small 11 (2015) 4517. doi: 10.1002/smll.201500997
178. [178]
  H.L. Yang, S.Q. Fang, Y.W. Tang, et al., Eur. J. Med. Chem. 179 (2019) 736–743. doi: 10.1016/j.ejmech.2019.07.005
179. [179]
  F. Chibhabha, Y. Yang, K. Ying, et al., J. Mater. Chem. B 8 (2020) 7438–7452. doi: 10.1039/D0TB01101K
180. [180]
  L. Quan, J. Wu, L.A. Lane, et al., Bioconjug. Chem. 27 (2016) 809–814. doi: 10.1021/acs.bioconjchem.6b00019
181. [181]
  K. Liu, T.L. Guo, J. Chojnacki, et al., ACS Chem. Neurosci. 3 (2012) 141–146. doi: 10.1021/cn200122j1-017-3688-8
182. [182]
  S.C. Lee, H.H. Park, S.H. Kim, et al., Anal. Chem. 91 (2019) 5573–5581. doi: 10.1021/acs.analchem.8b03735
183. [183]
  W. Gao, W. Wang, X. Dong, Y. Sun, Small 16 (2020) e2002804. doi: 10.1002/smll.202002804
184. [184]
  A.A. Elbatrawy, S.J. Hyeon, N. Yue, et al., ACS Sens. 6 (2021) 2281–2289. doi: 10.1021/acssensors.1c00338
185. [185]
  Y. Seo, K.S. Park, T. Ha, et al., ACS Chem. Neurosci. 7 (2016) 1474–1481. doi: 10.1021/acschemneuro.6b00174
186. [186]
  Z. He, D. Liu, Y. Liu, et al., Anal. Chem. 94 (2022) 10256–10262. doi: 10.1021/acs.analchem.2c01885
187. [187]
  D. Huang, Q. Wang, Y. Cao, et al., ACS Nano 17 (2023) 5033–5046. doi: 10.1021/acsnano.2c12840
188. [188]
  H. Li, J. Wang, Y. Li, et al., Sens. Actuators B 358 (2022) 131481. doi: 10.1016/j.snb.2022.131481
189. [189]
  L. Streich, C. Boffi, J.L. Wang, et al., Nat. Methods 18 (2021) 1253–1258. doi: 10.1038/s41592-021-01257-6
190. [190]
  C. Chen, Z. Liang, B. Zhou, et al., ACS Chem. Neurosci. 9 (2018) 3128–3136. doi: 10.1021/acschemneuro.8b00306
191. [191]
  X. Xie, G. Liu, Y. Niu, et al., Anal. Chem. 93 (2021) 15088–15095. doi: 10.1021/acs.analchem.1c03334
192. [192]
  D. Kim, S.H. Baik, S. Kang, et al., ACS Cent. Sci. 2 (2016) 967–975. doi: 10.1021/acscentsci.6b00309
193. [193]
  J. Yang, B. Zhu, W. Yin, et al., Chem. Sci. 11 (2020) 5238–5245. doi: 10.1039/D0SC02060E
194. [194]
  X. Xie, Y. Liu, G. Liu, et al., Chem. Commun. 58 (2022) 6300–6303. doi: 10.1039/D2CC01744J
195. [195]
  X. Wang, Y. Liu, X. Wang, et al., Biosens. Bioelectron. 238 (2023) 115563. doi: 10.1016/j.bios.2023.115563
196. [196]
  Z. Gong, Z. Liu, Z. Zhang, Y. Mei, Y. Tian, CCS Chem. 4 (2022) 2020–2030. doi: 10.31635/ccschem.021.202101038
197. [197]
  O. Babourina, Z. Rengel, Methods Mol. Biol. 913 (2012) 149–161.
198. [198]
  L. Ge, Y. Tian, Anal. Chem. 91 (2019) 3294–3301. doi: 10.1021/acs.analchem.8b03992
199. [199]
  D.E.S. Silva, M.P. Cali, W.M. Pazin, et al., J. Med. Chem. 59 (2016) 9215–9227. doi: 10.1021/acs.jmedchem.6b01130
200. [200]
  Y. Liu, S. Walter, M. Stagi, et al., Brain 128 (2005) 1778–1789. doi: 10.1093/brain/awh531
201. [201]
  Z. Wu, M. Liu, Z. Liu, Y. Tian, J. Am. Chem. Soc. 142 (2020) 7532–7541. doi: 10.1021/jacs.0c00771
202. [202]
  K.V. Kuchibhotla, C.R. Lattarulo, B.T. Hyman, B.J. Bacskai, Science 323 (2009) 1211–1215. doi: 10.1126/science.1169096
203. [203]
  N. Xia, B. Zhou, N. Huang, et al., Biosens. Bioelectron. 85 (2016) 625–632. doi: 10.1016/j.bios.2016.05.066
204. [204]
  F.O. Talbot, A. Rullo, H. Yao, R.A. Jockusch, J. Am. Chem. Soc. 132 (2010) 16156–16164. doi: 10.1021/ja1067405
205. [205]
  X.H. Wen, X.F. Zhao, X.H. Wang, et al., ACS Appl. Nano Mater. 5 (2022) 15925–15933. doi: 10.1021/acsanm.2c04187
206. [206]
  W.K. Fang, L. Liu, L.L. Zhang, et al., Anal. Chem. 93 (2021) 12447–12455. doi: 10.1021/acs.analchem.1c02679
207. [207]
  Q. Zhang, B. Yin, Y. Huang, et al., Biosens. Bioelectron. 230 (2023) 115270. doi: 10.1016/j.bios.2023.115270
208. [208]
  S. Lee, E. Kim, C.E. Moon, et al., Nat. Commun. 14 (2023) 8153. doi: 10.1038/s41467-023-43995-5
209. [209]
  X.P. He, Q. Deng, L. Cai, et al., ACS Appl. Mater. Interfaces 6 (2014) 5379–5382. doi: 10.1021/am5010909
210. [210]
  S.A. James, Q.I. Churches, M.D. de Jonge, ACS Chem. Neurosci. 8 (2016) 629–637.
211. [211]
  S. Zha, H. Liu, H. Li, et al., ACS Nano 18 (2024) 1820–1845. doi: 10.1021/acsnano.3c10674
212. [212]
  N. Gustavsson, A. Paulus, I. Martinsson, et al., Light Sci. Appl. 10 (2021) 151. doi: 10.1038/s41377-021-00590-x
213. [213]
  N. Fimognari, A. Hollings, V. Lam, et al., ACS Chem. Neurosci. 9 (2018) 2774–2785. doi: 10.1021/acschemneuro.8b00193
214. [214]
  L.G. Rodriguez, S.J. Lockett, G.R. Holtom, Cytom. Part A 69A (2006) 779–791. doi: 10.1002/cyto.a.20299
215. [215]
  D. Polli, V. Kumar, C.M. Valensise, M. Marangoni, G. Cerullo, Laser Photonics Rev. 12 (2018) 1800020. doi: 10.1002/lpor.201800020
216. [216]
  I. Kaya, D. Brinet, W. Michno, et al., ACS Chem. Neurosci. 8 (2017) 347–355. doi: 10.1021/acschemneuro.6b00391
217. [217]
  I. Kaya, H. Zetterberg, K. Blennow, J. Hanrieder, ACS Chem. Neurosci. 9 (2018) 1802–1817. doi: 10.1021/acschemneuro.8b00121
218. [218]
  C. Zhu, J. Han, F. Liang, et al., Coord. Chem. Rev. 517 (2024) 216002. doi: 10.1016/j.ccr.2024.216002
219. [219]
  J.P.R. Day, K.F. Domke, G. Rago, et al., J. Phys. Chem. B 115 (2011) 7713–7725. doi: 10.1021/jp200606e
220. [220]
  I. Uras, M. Karayel-Basar, B. Sahin, A.T. Baykal, Alzheimer’s Dement. 19 (2023) 4572–4589. doi: 10.1002/alz.13008
221. [221]
  L. Carlred, A. Gunnarsson, S. Solé-Domènech, J. Am. Chem. Soc. 136 (2014) 9973–9981. doi: 10.1021/ja5019145
222. [222]
  Y. Chen, C. Xie, X. Wang, et al., Anal. Chem. 94 (2022) 15367–15376. doi: 10.1021/acs.analchem.2c03089
223. [223]
  T.R. Hawkinson, H.A. Clarke, L.E.A. Young, Alzheimer’s Dement. 18 (2022) 1721–1735. doi: 10.1002/alz.12523
224. [224]
  Q. Zhang, Y. Li, P. Sui, et al., Talanta 266 (2024) 125022. doi: 10.1016/j.talanta.2023.125022
225. [225]
  N. Kakuda, T. Miyasaka, N. Iwasaki, Acta Neuropathol. Commun. 5 (2017) 73. doi: 10.1186/s40478-017-0477-x
226. [226]
  E. Llanos-González, F.J. Sancho-Bielsa, J. Frontiñán-Rubio, et al., Antioxidants 12 (2023) 747. doi: 10.3390/antiox12030747
227. [227]
  D.W. Moon, Y.H. Park, S.Y. Lee, et al., ACS Appl. Mater. Interfaces 12 (2020) 18056–18064. doi: 10.1021/acsami.9b21800
228. [228]
  K. Dimovska Nilsson, A. Karagianni, I. Kaya, M. Henricsson, J.S. Fletcher, Anal. Bioanal. Chem. 413 (2021) 4181–4194. doi: 10.1007/s00216-021-03372-x
229. [229]
  A.N. Lazar, C. Bich, M. Panchal, et al., Acta Neuropathol. 125 (2012) 133–144.
230. [230]
  R.W. Hutchinson, A.G. Cox, C.W. McLeod, et al., Anal. Biochem. 346 (2005) 225–233. doi: 10.1016/j.ab.2005.08.024
231. [231]
  X. Zhang, C. Wu, W. Tan, J. Proteome Res. 20 (2021) 2643–2650. doi: 10.1021/acs.jproteome.0c01050
232. [232]
  H. Zhang, F. Shi, Y. Yan, C. Deng, N. Sun, Adv. Healthc. Mater. 12 (2023) 2301136. doi: 10.1002/adhm.202301136
233. [233]
  Y. Li, S.E. Schindler, J.G. Bollinger, et al., Neurology 98 (2022) e688–e699.
234. [234]
  C. Hirtz, G.U. Busto, K. Bennys, et al., Alzheimer’s Res. Ther. 15 (2023) 34. doi: 10.1186/s13195-023-01188-8
235. [235]
  R. Haque, C.M. Watson, J. Liu, et al., Sci. Transl. Med. 15 (2023) eadg4122. doi: 10.1126/scitranslmed.adg4122
236. [236]
  T. West, K.M. Kirmess, M.R. Meyer, et al., Mol. Neurodegener. 16 (2021) 30. doi: 10.1186/s13024-021-00451-6
237. [237]
  N.R. Barthélemy, G. Salvadó, S.E. Schindler, et al., Nat. Med. 30 (2024) 1085–1095. doi: 10.1038/s41591-024-02869-z
238. [238]
  W. Le, G. Xu, S. Li, et al., Aging Dis. 11 (2020) 1459–1470. doi: 10.14336/AD.2020.0217
239. [239]
  Y. Garini, I.T. Young, G. McNamara, Cytom. Part A 69A (2006) 735–747. doi: 10.1002/cyto.a.20311
240. [240]
  M. Ji, M. Arbel, L. Zhang, et al., Sci. Adv. 4 (2018) eaat7715. doi: 10.1126/sciadv.aat7715
241. [241]
  K. Alkhuder, Photodiagn. Photodyn. Ther. 42 (2023) 103606. doi: 10.1016/j.pdpdt.2023.103606
242. [242]
  L. Huang, R. Luo, X. Liu, X. Hao, Light Sci. Appl. 11 (2022) 61. doi: 10.1038/s41377-022-00743-6
243. [243]
  L.M. Miller, M.W. Bourassa, R.J. Smith, Biochim. Biophys. Acta Biomembr. 1828 (2013) 2339–2346. doi: 10.1016/j.bbamem.2013.01.014
244. [244]
  N. Benseny-Cases, O. Klementieva, M. Cotte, I. Ferrer, J. Cladera, Anal. Chem. 86 (2014) 12047–12054. doi: 10.1021/ac502667b
245. [245]
  F. Palombo, F. Tamagnini, J.C.G. Jeynes, et al., Analyst 143 (2018) 850–857. doi: 10.1039/C7AN01747B
246. [246]
  M.P. Confer, B.M. Holcombe, A.G. Foes, et al., J. Phys. Chem. Lett. 12 (2021) 9662–9671. doi: 10.1021/acs.jpclett.1c02306
247. [247]
  G. Devitt, K. Howard, A. Mudher, S. Mahajan, ACS Chem. Neurosci. 9 (2018) 404–420. doi: 10.1021/acschemneuro.7b00413
248. [248]
  N. Kornienko, J. Resasco, N. Becknell, et al., J. Am. Chem. Soc. 137 (2015) 7448–7455. doi: 10.1021/jacs.5b03545
249. [249]
  A. Folick, W. Min, M.C. Wang, Curr. Opin. Genet. Dev. 21 (2011) 585–590. doi: 10.1016/j.gde.2011.09.003
250. [250]
  S.S. Sinha, S. Jones, A. Pramanik, P.C. Ray, Acc. Chem. Res. 49 (2016) 2725–2735. doi: 10.1021/acs.accounts.6b00384
251. [251]
  J. Tittel, F. Knechtel, E. Ploetz, Adv. Funct. Mater. 34 (2024) 2307518. doi: 10.1002/adfm.202307518
252. [252]
  H.J. Park, S. Cho, M. Kim, Y.S. Jung, Nano Lett. 20 (2020) 2576–2584. doi: 10.1021/acs.nanolett.0c00048
253. [253]
  J.K. Yang, I.J. Hwang, M.G. Cha, et al., Small 15 (2019) 1900613. doi: 10.1002/smll.201900613
254. [254]
  Y. Zhou, J. Liu, T. Zheng, Y. Tian, Anal. Chem. 92 (2020) 5910–5920. doi: 10.1021/acs.analchem.9b05837
255. [255]
  X. Liu, X. Su, M. Chen, Y. Xie, M. Li, Biosens. Bioelectron. 245 (2024) 115840. doi: 10.1016/j.bios.2023.115840
256. [256]
  Q. Xu, W. Liu, L. Li, et al., Chem. Commun. 53 (2017) 1880–1883. doi: 10.1039/C6CC09563A
257. [257]
  M. Sunder, N. Acharya, S. Nayak, N. Mazumder, Appl. Spectrosc. Rev. 56 (2020) 764–803.
258. [258]
  S. Li, Z. Luo, R. Zhang, et al., Biosensors 11 (2021) 365. doi: 10.3390/bios11100365
259. [259]
  D. Fu, W. Yang, X.S. Xie, J. Am. Chem. Soc. 139 (2016) 583–586.
260. [260]
  R.R. Jones, D.C. Hooper, L. Zhang, D. Wolverson, V.K. Valev, Nanoscale Res. Lett. 14 (2019) 231. doi: 10.1186/s11671-019-3039-2
261. [261]
  C.H.Jr. Camp, Y.J. Lee, J.M. Heddleston, et al., Nat. Photonics 8 (2014) 627–634. doi: 10.1038/nphoton.2014.145
262. [262]
  N.K. Mahanti, R. Pandiselvam, A. Kothakota, et al., Trends Food Sci. Technol. 120 (2022) 418–438. doi: 10.1016/j.tifs.2021.12.021
263. [263]
  X. Hadoux, F. Hui, J.K.H. Lim, et al., Nat. Commun. 10 (2019) 4227. doi: 10.1038/s41467-019-12242-1
264. [264]
  M. Vandenabeele, L. Veys, S. Lemmens, et al., Acta Neuropathol. Commun. 9 (2021) 6. doi: 10.1186/s40478-020-01102-5
265. [265]
  S.S. More, J.M. Beach, C. McClelland, A. Mokhtarzadeh, R. Vince, ACS Chem. Neurosci. 10 (2019) 4492–4501. doi: 10.1021/acschemneuro.9b00331
266. [266]
  X. Du, Y. Koronyo, N. Mirzaei, et al., PNAS Nexus 1 (2022) pgac164. doi: 10.1093/pnasnexus/pgac164
267. [267]
  S.S. More, J.M. Beach, R. Vince, Investig. Ophthalmol. Vis. Sci. 57 (2016) 3231–3238. doi: 10.1167/iovs.15-17406
268. [268]
  L.E. Jennings, N.J. Long, Chem. Commun. 24 (2009) 3511–3524.
269. [269]
  P.M. Wehrli, J. Ge, W. Michno, et al., JACS Au 3 (2023) 762–774. doi: 10.1021/jacsau.2c00492
270. [270]
  C.N. Jiao, Y.L. Gao, D.H. Ge, Eng. Appl. Artif. Intell. 130 (2024) 107782. doi: 10.1016/j.engappai.2023.107782
271. [271]
  W. Lin, W. Lin, G. Chen, et al., Front. Neurosci. 15 (2021) 646013. doi: 10.3389/fnins.2021.646013
272. [272]
  F. Liu, C.Y. Wee, H. Chen, D. Shen, Neuroimage 84 (2014) 466–475. doi: 10.1016/j.neuroimage.2013.09.015
273. [273]
  J. Cheng, H. Wang, S. Wei, et al., Comput. Biol. Med. 170 (2024) 108000. doi: 10.1016/j.compbiomed.2024.108000
274. [274]
  R. Camedda, C.G. Bonomi, M.G. Di Donna, A. Chiaravalloti, Int. J. Mol. Sci. 24 (2023) 751. doi: 10.3390/ijms24010751
275. [275]
  X. Wang, H.N. Chan, N. Desbois, et al., ACS Appl. Mater. Interfaces 13 (2021) 18525–18532. doi: 10.1021/acsami.1c01585
276. [276]
  J.H. Jhoo, D.Y. Lee, I.H. Choo, et al., Psychiatry Res. Neuroimaging 183 (2010) 237–243. doi: 10.1016/j.pscychresns.2010.03.006
277. [277]
  K.B. Walhovd, A.M. Fjell, I. Amlien, et al., Neuroimage 45 (2009) 215–223. doi: 10.1016/j.neuroimage.2008.10.053
278. [278]
  L. Lai, X. Jiang, S. Han, et al., Langmuir 33 (2017) 9018–9024. doi: 10.1021/acs.langmuir.7b01516
279. [279]
  M. Maruyama, H. Shimada, T. Suhara, et al., Neuron 79 (2013) 1094–1108. doi: 10.1016/j.neuron.2013.07.037
280. [280]
  W. Michno, I. Kaya, S. Nyström, et al., Anal. Chem. 90 (2018) 8130–8138. doi: 10.1021/acs.analchem.8b01361
281. [281]
  I. Kaya, D. Brinet, W. Michno, et al., ACS Chem. Neurosci. 8 (2017) 2778–2790. doi: 10.1021/acschemneuro.7b00314
282. [282]
  J. Ge, S. Koutarapu, D. Jha, et al., Anal. Chem. 95 (2023) 4692–4702. doi: 10.1021/acs.analchem.2c05302
283. [283]
  N. Hao, Z. Wang, P. Liu, et al., Biosens. Bioelectron. 196 (2022) 113730. doi: 10.1016/j.bios.2021.113730
284. [284]
  J.H. Lee, D.H. Kim, W.K. Song, M.K. Oh, D.K. Ko, Biomed. Opt. 20 (2015) 056013. doi: 10.1117/1.JBO.20.5.056013
285. [285]
  K.L. Summers, N. Fimognari, A. Hollings, et al., Biochemistry 56 (2017) 4107–4116. doi: 10.1021/acs.biochem.7b00262
286. [286]
  M. Zangiabadi, A. Ghosh, Y. Zhao, ACS Nano 17 (2023) 4764–4774. doi: 10.1021/acsnano.2c11186
287. [287]
  X. Wang, D. Niu, P. Li, et al., ACS Nano 96 (2015) 5646–5656.
288. [288]
  Z. Luo, H. Xu, S. Samanta, et al., Biomedicines 10 (2022) 2949. doi: 10.3390/biomedicines10112949
289. [289]
  S. Lemmens, T. Van Craenendonck, J. Van Eijgen, et al., Alzheimer’s Res. Ther. 12 (2020) 144. doi: 10.1186/s13195-020-00715-1
290. [290]
  C.I.P. Chaparro, B.T. Simões, J.P. Borges, et al., Pharmaceutics 15 (2023) 2316. doi: 10.3390/pharmaceutics15092316
291. [291]
  Y. Jiang, W. Li, Y. Ma, Y. Hou, J. Mater. Chem. B 13 (2025) 1424–1436. doi: 10.1039/D4TB02210F
292. [292]
  F. Morales-Zavala, P. Jara-Guajardo, D. Chamorro, et al., Biomater. Sci. 9 (2021) 4178–4190. doi: 10.1039/D0BM01825B
293. [293]
  G. Agraharam, N. Saravanan, A. Girigoswami, K. Girigoswami, BioNanoScience 12 (2022) 1002–1007. doi: 10.1007/s12668-022-00998-8
294. [294]
  N. Song, S. Sun, K. Chen, et al., J. Control. Release 360 (2023) 392–417. doi: 10.1016/j.jconrel.2023.07.004
295. [295]
  A. Panghal, S.J.S. Flora, Biochim. Biophys. Acta Gen. Subj. 1868 (2024) 130559. doi: 10.1016/j.bbagen.2024.130559
296. [296]
  X. Dai, Y. Li, Y. Zhong, Glob. J. Nano 4 (2018) 555644.
297. [297]
  L. Li, R. He, H. Yan, et al., Nano Today 47 (2022) 101654. doi: 10.1016/j.nantod.2022.101654
298. [298]
  C.L. Evans, X.S. Xie, Annu. Rev. Anal. Chem. 1 (2008) 883–909. doi: 10.1146/annurev.anchem.1.031207.112754
299. [299]
  C.H. Camp Jr, M.T. Cicerone, Nat. Photonics 9 (2015) 295–305. doi: 10.1038/nphoton.2015.60
300. [300]
  J. Sun, L. Li, W. Cai, A. Chen, R. Zhang, ACS Appl. Bio Mater. 4 (2021) 5312–5323. doi: 10.1021/acsabm.1c00423
301. [301]
  R. Chakravarty, H. Hong, W. Cai, Mol. Pharm. 11 (2014) 3777–3797. doi: 10.1021/mp500173s
302. [302]
  S.T.G. Bruijnen, D.M.S.H. Chandrupatla, L. Giovanonni, et al., Mol. Pharm. 16 (2018) 273–281.
303. [303]
  J. Ahlawat, G. Guillama Barroso, S. Masoudi Asil, et al., ACS Omega 5 (2020) 12583–12595. doi: 10.1021/acsomega.0c01592
304. [304]
  N. Lipsman, Y. Meng, A.J. Bethune, et al., Nat. Commun. 9 (2018) 2336. doi: 10.1038/s41467-018-04529-6
305. [305]
  A. Burgess, S. Dubey, S. Yeung, et al., Radiology 273 (2014) 736–745. doi: 10.1148/radiol.14140245
306. [306]
  A.R. Rezai, M. Ranjan, P.F. D’Haese, et al., Proc. Natl. Acad. Sci. U. S. A. 117 (2020) 9180–9182. doi: 10.1073/pnas.2002571117
307. [307]
  K. Xhima, K. Markham-Coultes, H. Nedev, et al., Sci. Adv. 6 (2020) eaax6646. doi: 10.1126/sciadv.aax6646
308. [308]
  R.M. Nisbet, A. Van der Jeugd, G. Leinenga, et al., Brain 140 (2017) 1220–1230. doi: 10.1093/brain/awx052
309. [309]
  A.I. Bush, S.B. Raymond, L.H. Treat, et al., PLoS One 3 (2008) e2175. doi: 10.1371/journal.pone.0002175
310. [310]
  J. Zhao, F. Yin, L. Ji, et al., ACS Appl. Mater. Interfaces 12 (2020) 44447–44458. doi: 10.1021/acsami.0c11064
311. [311]
  R. Beisteiner, E. Matt, C. Fan, et al., Adv. Sci. 23 (2019) 1902583.
312. [312]
  J. Wang, P. Shangguan, X. Chen, et al., Nat. Commun. 15 (2024) 705. doi: 10.1038/s41467-024-44737-x
313. [313]
  M. Sharma, V. Tiwari, S. Chaturvedi, et al., ACS Appl. Mater. Interfaces 14 (2022) 13079–13093. doi: 10.1021/acsami.2c01090
314. [314]
  K. Qian, X. Bao, Y. Li, et al., ACS Nano 16 (2022) 11455–11472. doi: 10.1021/acsnano.2c05795
315. [315]
  I. Ahmad, A. Mozhi, L. Yang, et al., Colloids Surf. B 159 (2017) 540–545. doi: 10.1016/j.colsurfb.2017.08.020
316. [316]
  D. Liu, B. Lin, W. Shao, et al., ACS Appl. Mater. Interfaces 6 (2014) 2131–2136. doi: 10.1021/am405219u
317. [317]
  T. Li, C. Li, Z. Ruan, et al., ACS Nano 13 (2019) 3691–3702. doi: 10.1021/acsnano.9b00452
318. [318]
  Y. Liu, Y. Chen, Y. Gong, H. Yang, J. Liu, ACS Appl. Nano Mater. 6 (2023) 5384–5393. doi: 10.1021/acsanm.2c05512
319. [319]
  K. Ge, Y. Mu, M. Liu, et al., ACS Appl. Mater. Interfaces 14 (2022) 3662–3674. doi: 10.1021/acsami.1c17861
320. [320]
  T. Yin, W. Xie, J. Sun, L. Yang, J. Liu, ACS Appl. Mater. Interfaces 8 (2016) 19291–19302. doi: 10.1021/acsami.6b05089
321. [321]
  M. Li, X. Yang, J. Ren, K. Qu, X. Qu, Adv. Mater. 24 (2012) 1722–1728. doi: 10.1002/adma.201104864
322. [322]
  E.N. Musa, K.C. Stylianou, Mol. Syst. Des. Eng. 8 (2023) 151–166. doi: 10.1039/D2ME00221C
323. [323]
  Z.W. Tay, P. Chandrasekharan, A. Chiu-Lam, et al., ACS Nano 12 (2018) 3699–3713. doi: 10.1021/acsnano.8b00893
324. [324]
  J.H. Yan, W. Meng, H. Shan, et al., ACS Appl. Nano Mater. 4 (2021) 1351–1363. doi: 10.1021/acsanm.0c02916
325. [325]
  A. Detappe, E. Thomas, M.W. Tibbitt, et al., Nano Lett. 17 (2017) 1733–1740. doi: 10.1021/acs.nanolett.6b05055
326. [326]
  N. Dong, P. Ali-Khiavi, N. Ghavamikia, et al., Neurol. Sci. 46 (2025) 1489–1507. doi: 10.1007/s10072-024-07871-4
327. [327]
  Q. Song, J. Li, T. Li, H.W. Li, Adv. Sci. 11 (2024) 2403473. doi: 10.1002/advs.202403473
328. [328]
  U. Aziz, H.G. Nigel, A.K. Mohammad, Curr. Med. Chem. 30 (2023) 255–270. doi: 10.2174/0929867329666220328125206
329. [329]
  M. Bilal, M. Barani, F. Sabir, A. Rahdar, G.Z. Kyzas, NanoImpact 20 (2020) 100251. doi: 10.1016/j.impact.2020.100251
330. [330]
  M.E. Wechsler, J.E. Vela Ramirez, N.A. Peppas, Ind. Eng. Chem. Res. 58 (2019) 15079–15087. doi: 10.1021/acs.iecr.9b02196
331. [331]
  E. Asimakidou, J.K.S. Tan, J. Zeng, C.H. Lo, Pharmaceuticals 17 (2024) 612. doi: 10.3390/ph17050612
332. [332]
  M.T. Khosroshahi, S. Morsali, S. Gharakhanlou, et al., Diagnostics 15 (2025) 612. doi: 10.3390/diagnostics15050612
333. [333]
  I. Malik, A. Iqbal, Y.H. Gu, M.A. Al-Antari, Diagnostics 14 (2024) 1281. doi: 10.3390/diagnostics14121281
334. [334]
  K. Fujita, M. Katsuki, A. Takasu, et al., Aging Med. 5 (2022) 167–173. doi: 10.1002/agm2.12224
335. [335]
  J.R. Teoh, J. Dong, X. Zuo, et al., PeerJ Comput. Sci. 10 (2024) e2298. doi: 10.7717/peerj-cs.2298
336. [336]
  X. Zhao, C.K.E. Ang, U.R. Acharya, K.H. Cheong, Biocybern. Biomed. Eng. 41 (2021) 456–473. doi: 10.1016/j.bbe.2021.02.006
337. [337]
  M.O. Etekochay, A.R. Amaravadhi, G.V. González, et al., J. Alzheimer’s Dis. 99 (2024) 1–20 https://journals.sagepub.com/doi/10.3233/JAD-231135. doi: 10.3233/JAD-231135
338. [338]
  H. Ashayeri, A. Jafarizadeh, M. Yousefi, et al., Clin. Exp. Ophthalmol. 262 (2024) 2389–2401.
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