Citation: Xingli Zhang, Peng Xue. Current trends in advanced imaging modalities for the early diagnosis of Alzheimer’s disease[J]. Chinese Chemical Letters, ;2026, 37(3): 111628. doi: 10.1016/j.cclet.2025.111628 shu

Current trends in advanced imaging modalities for the early diagnosis of Alzheimer’s disease

Xingli Zhang ^a ,
Peng Xue ^{a, b, *,}

a.
School of Materials and Energy, Southwest University, Chongqing 400715, China
b.
Yibin Academy of Southwest University, Yibin 644005, China

xuepeng@swu.edu.cn

Received Date: 2 April 2025
Revised Date: 26 June 2025
Accepted Date: 22 July 2025
Available Online: 24 July 2025

Figures(3)

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by complex pathological features such as amyloid-β plaques and tau tangles. Early and accurate diagnosis is crucial for effective intervention, yet remains challenging. This review focuses on current and emerging imaging modalities used in AD detection, including positron emission tomography, single-photon emission computed tomography, magnetic resonance imaging (MRI), fluorescence imaging, photoacoustic imaging, and mass spectrometry imaging, with an emphasis on their mechanisms, advantages, and limitations. Special attention is given to the integration of nanotechnology with imaging platforms, highlighting how nanomaterials enhance diagnostic specificity, sensitivity, stability and therapeutic potential. The review also explores recent advances in multimodal imaging, artificial intelligence-assisted diagnostics, and future directions toward personalized and other non-invasive strategies for early AD diagnosis.
- Alzheimer’s disease,
- Imaging technologies,
- Nanotechnology,
- Diagnosis,
- Theranostics
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