Citation: Jia-Lun Duan, Xin-Lan Zhang, Li-Qiang Zhao, Ya-Nan Liu, An-Ni Yao, Nian-Guang Li, Jin-Ao Duan, Chun-Jie Bao. Macrophage membrane-camouflaged nanoparticles for targeted drug delivery[J]. Chinese Chemical Letters, ;2026, 37(7): 111610. doi: 10.1016/j.cclet.2025.111610 shu

Macrophage membrane-camouflaged nanoparticles for targeted drug delivery

Jia-Lun Duan ^{a, 1} ,
Xin-Lan Zhang ^{a, 1} ,
Li-Qiang Zhao ^a ,
Ya-Nan Liu ^a ,
An-Ni Yao ^a ,
Nian-Guang Li ^{a, *,} ,
Jin-Ao Duan ^{a, *,} ,
Chun-Jie Bao ^{a, b, *,}

a.
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, Nanjing University of Chinese Medicine, Nanjing 210023, China
b.
School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China

linianguang@njucm.edu.cn

dja@njucm.edu.cn

chunjie@njucm.edu.cn

Received Date: 11 May 2025
Revised Date: 17 July 2025
Accepted Date: 18 July 2025
Available Online: 18 July 2025

Figures(5)

Macrophage membrane-camouflaged nanoparticles (MmNPs) are emerging as efficient nanoplatforms for targeted delivery to inflammatory sites, tumors, and infected tissues due to the innate characteristics of macrophages. This biomimetic strategy effectively addresses several limitations of traditional targeted drug delivery systems, offering improved biocompatibility, extended blood circulation, immune evasion, and site-specific homing. Compared to conventional functionalization methods, MmNPs provide a simplified method for creating multifunctional nanoparticles. In this review, we explore the origins and functions of macrophages, highlighting how MmNP platforms are leveraged for precise drug delivery. The latest applications of MmNPs in targeted delivery are summarized, focusing on their intrinsic targeting properties, membrane surface modifications and designs for environmental stimulus response. Finally, we discuss the prospects and challenges in translating MmNP technology from experimental settings to clinical applications, aiming to inspire continued innovation in the design of MmNP for precise and effective drug delivery strategies against complex diseases.
- Macrophage,
- Membrane-camouflaged nanoparticles,
- Targeted drug delivery system,
- Biomimetic strategy,
- Biomedical applications
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沈阳化工大学材料科学与工程学院沈阳 110142