Citation: Xin Cao, Shizhuo Xiao, Aichun Kang, Yu Wei, Xueting Yang, Dawei Li, Wendi Liu, Małgorzata Szczerska, Jun Lu, Shanyue Guan. Hierarchically stabilized Pt with layered double hydroxide to construct nanoalloy for highly efficient cancer therapy[J]. Chinese Chemical Letters, ;2026, 37(10): 111606. doi: 10.1016/j.cclet.2025.111606 shu

Hierarchically stabilized Pt with layered double hydroxide to construct nanoalloy for highly efficient cancer therapy

Xin Cao ^{a, b, 1} ,
Shizhuo Xiao ^{b, 1} ,
Aichun Kang ^{c, 1} ,
Yu Wei ^b ,
Xueting Yang ^{a, b} ,
Dawei Li ^{d, *,} ,
Wendi Liu ^a ,
Małgorzata Szczerska ^e ,
Jun Lu ^{a, *,} ,
Shanyue Guan ^{b, *,}

a.
Beijng University of Chemical Technology, Beijing 100190, China
b.
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
c.
Civil Aviation General Hospital, Beijing 100125, China
d.
Senior Department of Orthopedics, The Fourth Medical Center of PLA General Hospital, Beijing 100091, China
e.
Faculty of Electronics, Telecommunication, and Informatics, Gdansk University of Technology, Gdańsk 80-233, Poland

ldw309@126.com

lujun@mail.buct.edu.cn

guanshanyue@mail.ipc.ac.cn

Received Date: 31 May 2025
Revised Date: 15 July 2025
Accepted Date: 17 July 2025
Available Online: 18 July 2025

Figures(6)

Achieving optimal reactive oxygen species (ROS) production requires carefully balancing these interactions to maximize therapeutic efficacy. Herein, we have successfully developed a nanosystem through defect substitution using CuCoFe-layered double hydroxides (LDHs) as a template, followed by Pt reduction on the layer, the resulting nanoalloy, denoted as CuPt alloy@LDHs, demonstrating remarkable ROS production activity. This superior ROS production was attributed to its low Gibbs free energy barrier for generating hydroxyl radical (^·OH), as confirmed by both characterizations and density functional theory (DFT) calculations. Additionally, the nanoalloy exhibits good (NO_x)-like activity, effectively disrupting the intracellular NADH/NAD⁺ cycling balance and enabling self-cycling of endogenous H₂O₂. This work highlights that CuPt alloy@LDHs can effectively disrupt the redox homeostasis in tumor regions, significantly improving therapeutic efficacy and overcoming the limitations of current nanoalloy catalytic therapies.
- Alloy,
- Layered double hydroxides,
- Reactive oxygen species,
- Redox,
- Homeostasis
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