Citation: Longhui Hao, Yi Zhang, Ying Sun, Yanqi Han, Jun Ye, Hongliang Wang, Lili Gao, Dong Wang, Yue Gao, Yanfang Yang, Yuling Liu. Advances in nano-delivery systems for targeted natural product delivery to specific skin layers in disease therapy and skin care[J]. Chinese Chemical Letters, ;2026, 37(7): 111597. doi: 10.1016/j.cclet.2025.111597 shu

Advances in nano-delivery systems for targeted natural product delivery to specific skin layers in disease therapy and skin care

Longhui Hao ^a ,
Yi Zhang ^b ,
Ying Sun ^b ,
Yanqi Han ^b ,
Jun Ye ^b ,
Hongliang Wang ^b ,
Lili Gao ^b ,
Dong Wang ^{a, *,} ,
Yue Gao ^{b, *,} ,
Yanfang Yang ^{b, *,} ,
Yuling Liu ^{b, *,}

a.
Shenyang Pharmaceutical University, Shenyang 110016, China
b.
Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

dongwang@syphu.edu.cn

gaoyue@imm.ac.cn

yangyf@imm.ac.cn

ylliu@imm.ac.cn

Received Date: 26 March 2025
Revised Date: 15 July 2025
Accepted Date: 16 July 2025
Available Online: 16 July 2025

Figures(2)

Compared to synthetic chemical compounds, plant extracts derived from natural sources have emerged as the "new favorites" in the treatment and care of skin diseases due to their distinct advantages, including being environmentally friendly, sustainable, and safe. However, challenges such as poor solubility, limited permeability, and the barrier function of the stratum corneum significantly restrict the application of natural products in dermal drug delivery. Fortunately, advancements in nanotechnology offer promising solutions to overcome these challenges. Different skin diseases and treatments require the precise delivery of natural active ingredients to specific skin layers, and the unique structure of nanocarriers enables targeted delivery to achieve desired therapeutic outcomes. This paper begins by exploring the pathogenesis and therapeutic targets of common skin conditions, including atopic dermatitis (AD), psoriasis, decubitus ulcers, diabetic foot ulcers (DFUs), as well as applications in antioxidant therapies and anti-aging strategies. Furthermore, it provides a detailed overview of the depths and locations within the skin where active compounds must be delivered to exert their effects effectively. Subsequently, this review categorizes and examines natural products based on their therapeutic effects on various skin diseases. It then highlights the skin depths and specific sites that can be targeted by different delivery systems designed to enhance skin permeability, tailored to meet the needs of skin disease treatment or care. By addressing these aspects, this review aims to provide a valuable reference for advancing research on nano-delivery systems in the field of topical skin drug delivery for the treatment and management of skin diseases.
- Nano-delivery systems,
- Natural products,
- Topical skin drug delivery,
- Skin diseases,
- Skin care and beauty
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沈阳化工大学材料科学与工程学院沈阳 110142