Citation: Yan Yu, Cailing Gan, Kun Shi, Zhongwu Bei, Yang Yu, Meng Pan, Hanzhi Deng, Zhiyong Qian. Recent advances in drug delivery systems for pulmonary fibrosis therapy[J]. Chinese Chemical Letters, ;2026, 37(1): 111596. doi: 10.1016/j.cclet.2025.111596 shu

Recent advances in drug delivery systems for pulmonary fibrosis therapy

Yan Yu ^a ,
Cailing Gan ^b ,
Kun Shi ^b ,
Zhongwu Bei ^b ,
Yang Yu ^c ,
Meng Pan ^b ,
Hanzhi Deng ^b ,
Zhiyong Qian ^{b, *,}

a.
Department of Chemistry, School of Science, Xihua University, Chengdu 610039, China
b.
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
c.
Department of Peritoneal Oncology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China

zhiyongqian@scu.edu.cn

Received Date: 7 May 2025
Revised Date: 15 July 2025
Accepted Date: 16 July 2025
Available Online: 17 July 2025

Figures(5)

In recent years, different drugs therapies for treatment pulmonary fibrosis (PF) have gained much attention due to development of drug delivery technology and urgent clinical needs. PF treatment existed a variety of currently clinical problem but PF could be treated with different drugs potentially though drug delivery technology. This review systematically expounds its basic theory, various drug delivery technologies, and future development directions. In the introduction, the relationship between the pathological mechanism of PF and drug delivery, the basic principles of the drug delivery system and the biological barriers faced by pulmonary drug delivery are analyzed. This review details delivery of small molecule drug, macromolecular drug and cells, including chemical synthesis and natural small molecule drug delivery, as well as RNA and cell-based delivery. Finally, the challenges and perspectives of these drugs to treat PF delivery technologies are discussed and key aspects in the development of PF drugs are considered. We hoped that this review can provide comprehensive and in-depth theoretical reference and technical support for the drug treatment of PF.
- Pulmonary fibrosis,
- Drug delivery,
- Small molecule drugs,
- Macromolecular drugs,
- Liposome nanoparticles
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沈阳化工大学材料科学与工程学院沈阳 110142