Citation: Min Zhang, Ye Chen, Yanan Li, Yifan Zhao, Bai Lv, Jie Cao, Bing Yu, Hailin Cong. Manipulating extracellular matrix to enhance intratumor drug delivery for nanomaterial-based photothermal therapy[J]. Chinese Chemical Letters, ;2025, 36(12): 111588. doi: 10.1016/j.cclet.2025.111588 shu

Manipulating extracellular matrix to enhance intratumor drug delivery for nanomaterial-based photothermal therapy

Min Zhang ^{a, *,} ,
Ye Chen ^{b, c, 1} ,
Yanan Li ^a ,
Yifan Zhao ^b ,
Bai Lv ^b ,
Jie Cao ^{b, *,} ,
Bing Yu ^{a, d, *,} ,
Hailin Cong ^{a, e}

a.
Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China
b.
School of Pharmacy, Qingdao University, Qingdao 266071, China
c.
Department of Pharmacy, Qingdao Hospital of Traditional Chinese Medicine, Qingdao 266033, China
d.
State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China
e.
College of Chemistry, Chemical Engineering and Materials Science, Zaozhuang University, Zaozhuang 277160, China

zhangminxyz@qdu.edu.cn

caojie0829@qdu.edu.cn

yubing198@qdu.edu.cn

Received Date: 8 April 2025
Revised Date: 14 July 2025
Accepted Date: 15 July 2025
Available Online: 18 July 2025

Figures(4)

Photothermal therapy (PTT), characterized by its minimally invasive nature and highly selective tumor-killing ability, holds great potential for tumor therapy. Due to the outstanding photothermal performance and tumor targeting ability, nanomaterial-based photothermal agents (nano-PTAs) have further expanded the therapeutic horizons of PTT. However, the dense and complicated network of the tumor extracellular matrix (ECM) severely restricts the penetration of nano-PTAs into deep tumor tissues. Since elevated temperatures are only generated in the vicinity of nano-PTAs upon laser irradiation, the uneven distribution of these agents leads to incomplete tumor coverage across the tumor. Consequently, overcoming ECM barriers and enhancing tumor permeability are critical for the success of tumor PTT. To address this challenge, researchers have explored strategies that combine tumor ECM regulation with PTT to facilitate the deep diffusion of nano-PTAs. This review summarizes the latest advancements in designing nano-PTAs with ECM-remodeling capabilities, aiming to enable their uniform penetration throughout tumors. Additionally, we discuss the remaining obstacles and challenges in elucidating the mechanisms of ECM manipulation and understanding the interactions between nano-PTAs and ECM components during the penetration process.
- ECM remodeling,
- Tumor PTT,
- Enlarged tumor permeability,
- Uniform PTA distribution,
- Improved PTA delivery efficiency
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沈阳化工大学材料科学与工程学院沈阳 110142