Citation: Peipei Yang, Ying Qu, Bingyang Chu, Wen Chen, Xue Wei, Meng Pan, Mengyao Wang, Yun Yang, Qingya Liu, Yuhuan Zheng, Ting Niu, Zhiyong Qian. Selinexor-loaded polymeric micelle for multiple myeloma therapy[J]. Chinese Chemical Letters, ;2026, 37(7): 111586. doi: 10.1016/j.cclet.2025.111586 shu

Selinexor-loaded polymeric micelle for multiple myeloma therapy

Peipei Yang ^{a, 1} ,
Ying Qu ^{a, b, 1} ,
Bingyang Chu ^b ,
Wen Chen ^b ,
Xue Wei ^a ,
Meng Pan ^b ,
Mengyao Wang ^a ,
Yun Yang ^b ,
Qingya Liu ^b ,
Yuhuan Zheng ^a ,
Ting Niu ^{a, b, 1,*,} ,
Zhiyong Qian ^{b, *,}

a.
Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

niuting@wchscu.cn

anderson-qian@163.com

Received Date: 22 April 2025
Revised Date: 12 July 2025
Accepted Date: 14 July 2025
Available Online: 15 July 2025

Figures(4)

Multiple myeloma (MM) is the second most common hematological malignancy and still remains incurable. Selinexor (SEL) is the first-in-class exportin 1 (XPO1) inhibitor, and has demonstrated survival benefits in relapsed/refractory MM patients. Despite its therapeutic potential, dose-limiting toxicities frequently compromise SEL’s clinical utility and patients’ quality of life. In this work, to improve therapeutic efficacy and minimize side effects of SEL, we designed the monomethyl poly(ethylene glycol)-poly(ε-caprolactone) (mPEG-PCL) micelle-encapsulated nanoformulation for MM therapy. The mPEG-PCL-SEL micelle exhibited controlled release behavior and showed remarkable cytotoxicity in MM cells. Most importantly, in the orthotopic MM model, this micelle system exhibited impressive therapeutic efficacy at low dosages and significantly prolonged the survival of MM-bearing mice. Moreover, the mPEG-PCL-SEL micelle demonstrated a favorable safety profile with fewer gastrointestinal and constitutional symptoms. And we found that compared with the free-SEL, the mPEG-PCL-SEL micelle maintained the integrity of the intestinal barrier, and was more beneficial to the diversity of the intestinal microbiota, which may be related to the improved gastrointestinal tolerability, making it an effective and safe choice for MM treatment.
- Multiple myeloma,
- Selinexor,
- Micelle,
- Drug delivery,
- Intestinal microbiota
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沈阳化工大学材料科学与工程学院沈阳 110142