Citation: Xu Sun, Mengchen Luo, Xinyu Xie, Mengyao Liu, Weili Wang, Tian Zhang, Lei An, Jinjun Shao, Xiaochen Dong, Yu Cai. Thienothiadiazole-based NIR-Ⅱ D-A-D dye for fluorescence and photoacoustic imaging-navigated photothermal therapy[J]. Chinese Chemical Letters, ;2026, 37(6): 111509. doi: 10.1016/j.cclet.2025.111509 shu

Thienothiadiazole-based NIR-Ⅱ D-A-D dye for fluorescence and photoacoustic imaging-navigated photothermal therapy

Xu Sun ^a ,
Mengchen Luo ^a ,
Xinyu Xie ^a ,
Mengyao Liu ^a ,
Weili Wang ^a ,
Tian Zhang ^a ,
Lei An ^b ,
Jinjun Shao ^{a, *,} ,
Xiaochen Dong ^{a, *,} ,
Yu Cai ^{b, *,}

a.
State Key Laboratory of Flexible Electronics (LOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University, Nanjing 211800, China
b.
Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Cancer Center, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, China

iamjjshao@njtech.edu.cn

iamxcdong@njtech.edu.cn

caiyu@hmc.edu.cn

Received Date: 12 April 2025
Revised Date: 20 June 2025
Accepted Date: 25 June 2025
Available Online: 25 June 2025

Figures(4)

The development of organic dyes with fluorescence in the second near-infrared (NIR-Ⅱ, 1000–1700 nm) biological window is crucial for deep-tissue tumor phototheranostics. Herein, we synthesized a thienothiadiazole-based NIR-Ⅱ fluorescent dye TTDOC with donor-acceptor-donor (D-A-D) molecular architecture for photoacoustic/fluorescence imaging-guided photothermal therapy (PTT). NIR-Ⅱ dye TTDOC, taking electron-deficient thienothiadiazole as an acceptor and triphenylamine as a donor, exhibited a high fluorescence quantum yield of 1.7% in dichloromethane (IR-1061 as standard, 1.7% in dichloromethane). Upon encapsulation in biocompatible polymer F-127, TTDOC nanoparticles (NPs) were formulated with NIR absorption and fluorescence band covering 900–1150 nm, and demonstrated an outstanding photothermal conversion efficiency (η) of 51.6% upon 808 nm photoirradiation. In vivo studies, including fluorescence and photoacoustic imaging, revealed that TTDOC NPs effectively accumulated in tumor tissues, reaching maximal tumor enrichment at 20 h post-injection. In vitro and in vivo results confirmed the ability of TTDOC NPs to enable efficient photoacoustic/fluorescence imaging-guided PTT, offering a promising strategy for deep-tissue tumor treatment.
- NIR-Ⅱ dyes,
- Photoacoustic,
- Fluorescence,
- Photothermal,
- Phototheranostics
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