Citation: Qun Zhang, Zhengkun Liu, Keke Wu, Zhipeng Zhang, Weisheng Guo, Xiaoying Guan. Biomaterials for regulating the micro-environment of diabetic foot ulcers[J]. Chinese Chemical Letters, ;2026, 37(6): 111493. doi: 10.1016/j.cclet.2025.111493 shu

Biomaterials for regulating the micro-environment of diabetic foot ulcers

Qun Zhang ^b ,
Zhengkun Liu ^b ,
Keke Wu ^b ,
Zhipeng Zhang ^{c, *,} ,
Weisheng Guo ^{b, *,} ,
Xiaoying Guan ^{a, b, *,}

a.
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
b.
The School of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, China
c.
Xianning Medical University, Hubei University of Science & Technology, Xianning 437000, China

zzplbeckham@hbust.edu.cn

tjuguoweisheng@126.com

guanxiaoying@gzhmu.edu.cn

Received Date: 9 December 2024
Revised Date: 16 June 2025
Accepted Date: 18 June 2025
Available Online: 18 June 2025

Figures(1)

Diabetic foot ulcers (DFUs) pose substantial clinical challenges due to their high prevalence, intricate pathophysiology, and recalcitrance to conventional therapeutic interventions. Traditional treatment paradigms frequently overlook the multidimensional aspects of DFUs, resulting in protracted healing trajectories and escalated risks of adverse sequelae. To address this critical diabetes-related complication, this comprehensive review delves into the pioneering application of biomaterials as microenvironmental modulators, underscoring their transformative potential in accelerating wound repair. By synthesizing in vivo, in vitro, and clinical evidence, we elucidate the mechanistic underpinnings and translational promise of these advanced materials. Our objective is to engage scholarly readers with state-of-the-art advancements in biomaterial engineering, emphasizing their pivotal contribution to paradigm shifts in DFU management strategies.
- Diabetic foot ulcer,
- Diabetic wound therapy challenges,
- Biomaterials,
- Micro-environmental factors,
- Micro-environmental regulation
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沈阳化工大学材料科学与工程学院沈阳 110142