Citation: Wei-Cheng Zhao, Yan He, Chen-Hui Jiang, Peng Liu, Qian Gao, Duo-Duo Hu, Xi-Sheng Wang. Asymmetric construction of non-activated C-SCF₃ stereocenter via copper-catalyzed hydroallylation of SCF₃-alkenes[J]. Chinese Chemical Letters, ;2026, 37(2): 111487. doi: 10.1016/j.cclet.2025.111487 shu

Asymmetric construction of non-activated C-SCF₃ stereocenter via copper-catalyzed hydroallylation of SCF₃-alkenes

Wei-Cheng Zhao ^a ,
Yan He ^a ,
Chen-Hui Jiang ^a ,
Peng Liu ^a ,
Qian Gao ^a ,
Duo-Duo Hu ^{b, *,} ,
Xi-Sheng Wang ^{a, *,}

a.
Key Laboratory of Precision and Intelligent Chemistry, University of Science and Technology of China, Hefei 230026, China
b.
School of Chemical and Blasting Engineering, Anhui University of Science and Technology, Huainan 232001, China

hdd19096@mail.ustc.edu.cn

xswang77@ustc.edu.cn

Received Date: 1 April 2025
Revised Date: 4 June 2025
Accepted Date: 17 June 2025
Available Online: 18 June 2025

Figures(4)

Fluorinated motifs are prevalent in both pharmaceuticals and agrochemicals. The incorporation of fluorine-containing moieties to drug candidates has emerged as a potent strategy for lead optimization in pharmaceutical research and development. While extensive research has been devoted to constructing molecules that incorporate a trifluoromethylthio (SCF₃−) group on a stereogenic carbon, the synthesis of trifluoromethylthiolated alkanes featuring a SCF₃-substituted stereogenic carbon at non-activated site remains understudied. Herein, we report a Cu-catalyzed regio- and enantioselective hydroallylation of 1-trifluoromethylthiolated alkenes. Important to the process is the regio- and enantioselective Cu-H insertion to SCF₃-substituted alkene to form chiral α-SCF₃ alkyl copper intermediates, outcompeting unproductive insertion to the coupling partner, and eventually proceed to afford optically active homoallylic trifluoromethylthiolated products.
- Asymmetric construction,
- Non-activated,
- Hydroallylation,
- Trifluoromethylthio group,
- Copper-catalyzed
1. [1]
  J. Patocka, A. Dvorak, J. Appl. Med. 2 (2004) 95–100. doi: 10.32725/jab.2004.011
2. [2]
  L.A. Nguyen, H. He, C. Pham-Huy, Int. J. Biomed. Sci. 2 (2006) 85–100. doi: 10.1002/mrdd.20103
3. [3]
  N. Chhabra, M.L. Aseri, D. Padmanabhan, Int. J. Appl. Basic Med. Res. 3 (2013) 16–18. doi: 10.4103/2229-516X.112233
4. [4]
  M. Eichelbaum, A.S. Gross, Adv. Drug Res. 28 (1996) 1–64.
5. [5]
  S.W. Smith, Toxicol. Sci. 110 (2009) 4–30. doi: 10.1093/toxsci/kfp097
6. [6]
  N. Chhabra, M.L. Aseri, D. Padmanabhan, Int. J. Appl. Basic Med. Res. 3 (2013) 16–18. doi: 10.4103/2229-516X.112233
7. [7]
  H. Alkadi, R. Jbeily, Infect. Disord. Drug Targets 18 (2018) 88–95. doi: 10.2174/1871526517666170329123845
8. [8]
  K. Müller, C. Faeh, F. Diederich, Science 317 (2007) 1881–1886. doi: 10.1126/science.1131943
9. [9]
  S. Purser, P.R. Moore, S. Swallowb, V. Gouverneur, Chem. Soc. Rev. 37 (2008) 320–330. doi: 10.1039/B610213C
10. [10]
  J. Wang, M. Sánchez-Roselló, J.L. Aceña, et al., Chem. Rev. 114 (2014) 2432–2506. doi: 10.1021/cr4002879
11. [11]
  E.P. Gillis, K.J. Eastman, M.D. Hill, D.J. Donnelly, N.A. Meanwell, J. Med. Chem. 58 (2015) 8315–8359. doi: 10.1021/acs.jmedchem.5b00258
12. [12]
  N.A. Meanwell, J. Med. Chem. 61 (2018) 5822–5880. doi: 10.1021/acs.jmedchem.7b01788
13. [13]
  H. Mei, J. Han, S. Fustero, et al., Chem. Eur J. 25 (2019) 11797–11819. doi: 10.1002/chem.201901840
14. [14]
  M. Inoue, Y. Sumii, N. Shibata, ACS Omega 5 (2020) 10633–10640. doi: 10.1021/acsomega.0c00830
15. [15]
  B.M. Johnson, Y.Z. Shu, X. Zhuo, N.A. Meanwell, J. Med. Chem. 63 (2020) 6315–6386. doi: 10.1021/acs.jmedchem.9b01877
16. [16]
  Y. Yu, A. Liu, G. Dhawan, et al., Chin. Chem. Lett. 32 (2021) 3342–3354. doi: 10.1016/j.cclet.2021.05.042
17. [17]
  J. Li, W. Xi, S. Liu, et al., Chin. Chem. Lett. 33 (2022) 3007–3011. doi: 10.1016/j.cclet.2021.12.002
18. [18]
  N. Meng, Y. Lv, X. Zhao, W. Wei, Chin. Chem. Lett. 32 (2021) 258–262. doi: 10.1016/j.cclet.2020.11.034
19. [19]
  R. Wang, J. Xu, J.X. Li, et al., Chin. Chem. Lett. 34 (2023) 108490. doi: 10.1016/j.cclet.2023.108490
20. [20]
  D.S. Deng, S.Q. Tang, Y.T. Yuan, et al., Chin. Chem. Lett. 35 (2024) 109417.
21. [21]
  L. Yang, Y. Li, M. Jiang, et al., Chin. Chem. Lett. 35 (2024) 109512. doi: 10.1016/j.cclet.2024.109512
22. [22]
  C.C. Wu, B.L. Wang, J.B. Liu, et al., Chin. Chem. Lett. 28 (2017) 1248–1251.
23. [23]
  X.J. Song, Y. Shao, X.G. Dong, Chin. Chem. Lett. 22 (2011) 1036–1038. doi: 10.1016/j.cclet.2011.05.012
24. [24]
  X. Chen, Z. Zhu, S. Liu, Y.H. Chen, X. Shen, Chin. Chem. Lett. 33 (2022) 2391–2396. doi: 10.1016/j.cclet.2021.10.083
25. [25]
  H. Wang, Y. Xie, Y. Zhou, N. Cen, W. Chen, Chin. Chem. Lett. 33 (2022) 221–224.
26. [26]
  T.D. Beeson, D.W.C. MacMillan, J. Am. Chem. Soc. 127 (2005) 8826–8828. doi: 10.1021/ja051805f
27. [27]
  M. Marigo, D. Fielenbach, A. Braunton, A. Kjærsgaard, K.A. Jørgensen, Angew. Chem. Int. Ed. 44 (2005) 3703–3706. doi: 10.1002/anie.200500395
28. [28]
  D. Cahard, X. Xu, S. Couve-Bonnaire, X. Pannecoucke, Chem. Soc. Rev. 39 (2010) 558–568. doi: 10.1039/B909566G
29. [29]
  S. Lectard, Y. Hamashima, M. Sodeoka, Adv. Synth. Catal. 352 (2010) 2708–2732. doi: 10.1002/adsc.201000624
30. [30]
  C.Y. Huang, A.G. Doyle, J. Am. Chem. Soc. 134 (2012) 9541–9544. doi: 10.1021/ja3013825
31. [31]
  R.J. Phipps, F.D. Toste, J. Am. Chem. Soc. 135 (2013) 1268–1271. doi: 10.1021/ja311798q
32. [32]
  N.A. Cochrane, H. Nguyen, M.R. Gagne, J. Am. Chem. Soc. 135 (2013) 628–631. doi: 10.1021/ja3116795
33. [33]
  X. Yang, R.J. Phipps, F.D. Toste, J. Am. Chem. Soc. 136 (2014) 5225–5228. doi: 10.1021/ja500882x
34. [34]
  S.Y. Lee, S. Neufeind, G.C. Fu, J. Am. Chem. Soc. 136 (2014) 8899–8902. doi: 10.1021/ja5044209
35. [35]
  X. Jiang, M. Gandelman, J. Am. Chem. Soc. 137 (2015) 2542–2547. doi: 10.1021/jacs.5b00473
36. [36]
  A. Leo, C. Hansch, D. Elkins, Chem. Rev. 71 (1971) 525–616. doi: 10.1021/cr60274a001
37. [37]
  C. Hansch, S.H. Unger, A.B. Forsythe, J. Med. Chem. 16 (1973) 1217–1222. doi: 10.1021/jm00269a004
38. [38]
  C. Hansch, A. Leo, R.W. Taft, Chem. Rev. 91 (1991) 165–195. doi: 10.1021/cr00002a004
39. [39]
  G.W. Counts, D. Gregory, D. Zeleznik, M. Turck, Antimicrob. Agents Chemother. 11 (1977) 708–711. doi: 10.1128/AAC.11.4.708
40. [40]
  N. Aswapokee, H.C. Neu, Antimicrob. Agents Chemother. 15 (1979) 444–446. doi: 10.1128/AAC.15.3.444
41. [41]
  N.J.W. Straathof, B.J.P. Tegelbeckers, V, Hessel, X. Wang, T. Noël, Chem. Sci. 5 (2014) 4768–4773. doi: 10.1039/C4SC01982B
42. [42]
  K. Jouvin, C. Matheis, L.J. Goossen, Chem. Eur. J. 21 (2015) 14324–14327. doi: 10.1002/chem.201502914
43. [43]
  S. Alazet, T. Billard, Synlett 26 (2015) 76–78. doi: 10.1055/s-0034-1380555
44. [44]
  X. -H. Xu, K. Matsuzaki, N. Shibata, Chem. Rev. 115 (2015) 731–764. doi: 10.1021/cr500193b
45. [45]
  S. Barata-Vallejo, S. Bonesi, A. Postigo, Org. Biomol. Chem. 14 (2016) 7150–7182.
46. [46]
  M. Zhao, X. Zhao, P. Zheng, Y. Tian, J. Fluorine Chem. 194 (2017) 73–79. doi: 10.1016/j.jfluchem.2017.01.007
47. [47]
  A. -L. Barthelemy, E. Magnier, G. Dagousset, Synthesis (Mass) 50 (2018) 4765–4776. doi: 10.1055/s-0037-1611278
48. [48]
  C. Ghiazza, T. Billard, A. Tlili, Chem. Eur. J. 25 (2019) 6482–6495. doi: 10.1002/chem.201806234
49. [49]
  Y. Huang, M. Zhang, Q. Lin, Z. Weng, Synlett. 32 (2021) 109–118. doi: 10.1055/s-0040-1707211
50. [50]
  L. Liao, X. Zhao, Acc. Chem. Res. 55 (2022) 2439–2453. doi: 10.1021/acs.accounts.2c00201
51. [51]
  X. Wang, T. Yang, X. Cheng, Q. Shen, Angew. Chem. Int. Ed. 52 (2013) 12860–12864. doi: 10.1002/anie.201305075
52. [52]
  T. Bootwicha, X. Liu, R. Pluta, I. Atodiresei, M. Rueping, Angew. Chem. Int. Ed. 52 (2013) 12856–12859. doi: 10.1002/anie.201304957
53. [53]
  M. Rueping, X. Liu, T. Bootwicha, R. Pluta, C. Merkens, Chem. Commun. 50 (2014) 2508–2511. doi: 10.1039/c3cc49877h
54. [54]
  X.L. Zhu, J.H. Xu, D.J. Cheng, et al., Org. Lett. 16 (2014) 2192–2195. doi: 10.1021/ol5006888
55. [55]
  Q.H. Deng, C. Rettenmeier, H. Wadepohl, L.H. Gade, Chem. Eur. J. 20 (2014) 93–97. doi: 10.1002/chem.201303641
56. [56]
  B.L. Zhao, D.M. Du, Org. Lett. 19 (2017) 1036–1039. doi: 10.1021/acs.orglett.6b03846
57. [57]
  M. Li, X.S. Xue, J.P. Cheng, ACS Catal. 7 (2017) 7977–7986. doi: 10.1021/acscatal.7b03007
58. [58]
  H. Zhang, X. Leng, X. Wan, Q. Shen, Org. Chem. Front. 4 (2017) 1051–1057. doi: 10.1039/C7QO00042A
59. [59]
  M.Y. Jin, J. Li, R. Huang, et al., Chem. Commun. 54 (2018) 4581–4584. doi: 10.1039/c8cc02097c
60. [60]
  F. Gelat, T. Poisson, A.T. Biju, X. Pannecoucke, T. Besset, Eur. J. Org. Chem. 2018 (2018) 3693–3696. doi: 10.1002/ejoc.201800418
61. [61]
  M.A. Hardy, H. Chachignon, D. Cahard, Asian J. Org. Chem. 8 (2019) 591–609. doi: 10.1002/ajoc.201900004
62. [62]
  V. Capaccio, M. Sicignano, R.I. Rodriguez, G. Della Sala, J. Aleman, Org. Lett. 22 (2020) 219–223. doi: 10.1021/acs.orglett.9b04195
63. [63]
  M. Sicignano, R.I. Rodriguez, V. Capaccio, et al., Org. Biomol. Chem. 18 (2020) 2914–2920. doi: 10.1039/d0ob00476f
64. [64]
  A. Eitzinger, J.F. Briere, D. Cahard, M. Waser, Org. Biomol. Chem. 18 (2020) 405–408. doi: 10.1039/c9ob02666e
65. [65]
  A. Eitzinger, J. Otevrel, V. Haider, et al., Adv. Synth. Catal. 363 (2021) 1955–1962. doi: 10.1002/adsc.202100029
66. [66]
  X. Liu, R. An, X. Zhang, J. Luo, X. Zhao, Angew. Chem. Int. Ed. 55 (2016) 5846–5850. doi: 10.1002/anie.201601713
67. [67]
  J. Luo, Y. Liu, X. Zhao, Org. Lett. 19 (2017) 3434–3437. doi: 10.1021/acs.orglett.7b01392
68. [68]
  J. Luo, X. Liu, X. Zhao, Synlett 28 (2017) 397–401. doi: 10.1055/s-0036-1588926
69. [69]
  X. Liu, Y. Lang, J. Ji, J. Luo, X. Zhao, J. Am. Chem. Soc. 140 (2018) 4782–4786. doi: 10.1021/jacs.8b01513
70. [70]
  J. Luo, Q. Cao, X. Cao, X. Zhao, Nat. Commun. 9 (2018) 527. doi: 10.1038/s41467-018-02955-0
71. [71]
  J. Xu, Y. Zhang, T. Qin, X. Zhao, Org. Lett. 20 (2018) 6384–6388. doi: 10.1021/acs.orglett.8b02672
72. [72]
  T. Qin, Q. Jiang, J. Ji, J. Luo, X. Zhao, Org. Biomol. Chem. 17 (2019) 1763–1766. doi: 10.1039/c8ob02575d
73. [73]
  Q. Jiang, X. Zhao, Chin. J. Org. Chem. 41 (2021) 443–454. doi: 10.6023/cjoc202010005
74. [74]
  X. Gao, Y.L. Xiao, S. Zhang, J. Wu, X. Zhang, CCS Chem. 3 (2021) 1463–1471. doi: 10.31635/ccschem.020.202000353
75. [75]
  Q. Wang, T. Nilsson, L. Eriksson, K.J. Szabo, Angew. Chem. Int. Ed. 61 (2022) e202210509. doi: 10.1002/anie.202210509
76. [76]
  J. Zhou, Q.F. Zhang, W.H. Zhao, G.F. Jiang, Org. Biomol. Chem. 14 (2016) 6937–6941. doi: 10.1039/C6OB01176D
77. [77]
  L. Xu, H. Wang, C. Zheng, G. Zhao, Adv. Synth. Catal. 359 (2017) 2942–2948. doi: 10.1002/adsc.201700321
78. [78]
  Z. Zhang, Z. Sheng, W. Yu, et al., Nature Chem. 9 (2017) 970–976. doi: 10.1038/nchem.2789
79. [79]
  H. Kondo, M. Maeno, K. Sasaki, et al., Org. Lett. 20 (2018) 7044–7048. doi: 10.1021/acs.orglett.8b02998
80. [80]
  D.D. Hu, T.M. Nie, X. Xiao, et al., Angew. Chem. Int. Ed. 63 (2024) e202400308. doi: 10.1002/anie.202400308
81. [81]
  Y. Kojima, Y. Nishii, K. Hirano, Angew. Chem. Int. Ed. 63 (2024) e202403337.
82. [82]
  Y.M. Wang, S.L. Buchwald, J. Am. Chem. Soc. 138 (2016) 5024–5027. doi: 10.1021/jacs.6b02527
83. [83]
  J.T. Han, W.J. Jang, N. Kim, J. Yun, J. Am. Chem. Soc. 138 (2016) 15146–15149. doi: 10.1021/jacs.6b11229
84. [84]
  J. Lee, S. Torker, A.H. Hoveyda, Angew. Chem. Int. Ed. 56 (2017) 821–826. doi: 10.1002/anie.201611444
85. [85]
  Y. Kojima, M. Miura, K. Hirano, ACS Catal. 11 (2021) 11663–11670. doi: 10.1021/acscatal.1c02947
1. [1]
  Jialin Huang , Liying Fu , Zhanyong Tang , Xiaoqiang Ma , Xingda Zhao , Depeng Zhao . Cross-coupling of trifluoromethylarenes with alkynes C(sp)-H bonds and azoles C(sp²)-H bonds via photoredox/copper dual catalysis. Chinese Chemical Letters, 2025, 36(7): 110505-. doi: 10.1016/j.cclet.2024.110505
2. [2]
  Yixiao Zhao , Gavin Chit Tsui , Qilong Shen . Key intermediates in Cu^Ⅰ to Cu^Ⅲ catalytic cycle for ethoxycarbonyl difluoro- methylation. Chinese Chemical Letters, 2025, 36(12): 111051-. doi: 10.1016/j.cclet.2025.111051
3. [3]
  Ji-Jia Zhou , Li-Gao Liu , Zhen-Tao Zhang , Hao-Xuan Dong , Xin Lu , Zhou Xu , Xin-Qi Zhu , Bo Zhou , Long-Wu Ye . Copper-catalyzed asymmetric cascade diyne cyclization/Meinwald rearrangement. Chinese Chemical Letters, 2025, 36(9): 110870-. doi: 10.1016/j.cclet.2025.110870
4. [4]
  Guang Xu , Cuiju Zhu , Xiang Li , Kexin Zhu , Hao Xu . Copper-catalyzed asymmetric [4+1] annulation of yne–allylic esters with pyrazolones. Chinese Chemical Letters, 2025, 36(4): 110114-. doi: 10.1016/j.cclet.2024.110114
5. [5]
  Yi-Kao Xu , Guo-Ping Luo , Liang-Bin Hu , Wei-Min He . Asymmetric Büchner reaction and arene cyclopropanation via copper-catalyzed controllable cyclization of diynes. Chinese Chemical Letters, 2025, 36(8): 111226-. doi: 10.1016/j.cclet.2025.111226
6. [6]
  Pan Zhou , Ting Zou , Hong-Jian Song , Yu-Xiu Liu , Qing-Min Wang . Advances in organoelectrochemical copper-catalyzed reactions. Chinese Chemical Letters, 2026, 37(1): 111673-. doi: 10.1016/j.cclet.2025.111673
7. [7]
  Ruixue Liu , Xiaobing Ding , Qiwei Lang , Gen-Qiang Chen , Xumu Zhang . Enantioselective and divergent construction of chiral amino alcohols and oxazolidin-2-ones via Ir-f-phamidol-catalyzed dynamic kinetic asymmetric hydrogenation. Chinese Chemical Letters, 2025, 36(3): 110037-. doi: 10.1016/j.cclet.2024.110037
8. [8]
  Jing-Qi Tao , Shuai Liu , Tian-Yu Zhang , Hong Xin , Xu Yang , Xin-Hua Duan , Li-Na Guo . Photoinduced copper-catalyzed alkoxyl radical-triggered ring-expansion/aminocarbonylation cascade. Chinese Chemical Letters, 2024, 35(6): 109263-. doi: 10.1016/j.cclet.2023.109263
9. [9]
  He Yao , Wenhao Ji , Yi Feng , Chunbo Qian , Chengguang Yue , Yue Wang , Shouying Huang , Mei-Yan Wang , Xinbin Ma . Copper-catalyzed and biphosphine ligand controlled 3,4-boracarboxylation of 1,3-dienes with carbon dioxide. Chinese Chemical Letters, 2025, 36(4): 110076-. doi: 10.1016/j.cclet.2024.110076
10. [10]
  Qi Li , Zi-Lu Wang , Yun-He Xu . Copper-catalyzed 1,4-silylcyanation of 1,3-enynes: A silyl radical-initiated approach for synthesis of difunctionalized allenes. Chinese Chemical Letters, 2025, 36(3): 109991-. doi: 10.1016/j.cclet.2024.109991
11. [11]
  Yan-Bo Li , Yi Li , Liang Yin . Copper(Ⅰ)-catalyzed diastereodivergent construction of vicinal P-chiral and C-chiral centers facilitated by dual "soft-soft" interaction. Chinese Chemical Letters, 2024, 35(7): 109294-. doi: 10.1016/j.cclet.2023.109294
12. [12]
  Mengfan Zhang , Lingyan Liu , Peng Wei , Wei Feng , Tao Yi . A proximity tagging strategy utilizing an activated aldehyde group as the active site. Chinese Chemical Letters, 2025, 36(4): 110127-. doi: 10.1016/j.cclet.2024.110127
13. [13]
  Liangfeng Yang , Liang Zeng , Yanping Zhu , Qiuan Wang , Jinheng Li . Copper-catalyzed photoredox 1,4-amidocyanation of 1,3-enynes with N-amidopyridin-1-ium salts and TMSCN: Facile access to α-amido allenyl nitriles. Chinese Chemical Letters, 2024, 35(11): 109685-. doi: 10.1016/j.cclet.2024.109685
14. [14]
  Long Jin , Jian Han , Dongmei Fang , Min Wang , Jian Liao . Pd-catalyzed asymmetric carbonyl alkynylation: Synthesis of axial chiral ynones. Chinese Chemical Letters, 2024, 35(6): 109212-. doi: 10.1016/j.cclet.2023.109212
15. [15]
  Yanxin Jiang , Kwai Wun Cheng , Zhiping Yang , Jun (Joelle) Wang . Pd-catalyzed enantioselective and regioselective asymmetric hydrophosphorylation and hydrophosphinylation of enynes. Chinese Chemical Letters, 2025, 36(5): 110231-. doi: 10.1016/j.cclet.2024.110231
16. [16]
  Ya-Ling Li , Jia-Wei Ke , Yue Liu , Dong-Mei Yao , Jing-Dong Zhang , You-Cai Xiao , Fen-Er Chen . Asymmetric conjugated addition of aryl Grignard reagents for the construction of chromanones bearing quaternary stereogenic centers in batch and flow. Chinese Chemical Letters, 2025, 36(6): 110377-. doi: 10.1016/j.cclet.2024.110377
17. [17]
  Yu-Yu Tan , Lin-Heng He , Wei-Min He . Copper-mediated assembly of SO₂F group via radical fluorine-atom transfer strategy. Chinese Chemical Letters, 2024, 35(9): 109986-. doi: 10.1016/j.cclet.2024.109986
18. [18]
  Wei-Bin Li , Xiao-Chao Huang , Pei Liu , Jie Kong , Guo-Ping Yang . Recent advances in directing group assisted transition metal catalyzed para-selective C-H functionalization. Chinese Chemical Letters, 2025, 36(6): 110543-. doi: 10.1016/j.cclet.2024.110543
19. [19]
  Xinghao Cai , Chen Ma , Ying Kang , Yuqiang Ren , Xue Meng , Wei Lu , Shiming Fan , Shouxin Liu . Nickel-catalyzed C(sp²)–H alkynylation of free α-substituted benzylamines using a transient directing group. Chinese Chemical Letters, 2025, 36(10): 110901-. doi: 10.1016/j.cclet.2025.110901
20. [20]
  Zhen Liu , Zhi-Yuan Ren , Chen Yang , Xiangyi Shao , Li Chen , Xin Li . Asymmetric alkenylation reaction of benzoxazinones with diarylethylenes catalyzed by B(C₆F₅)₃/chiral phosphoric acid. Chinese Chemical Letters, 2024, 35(5): 108939-. doi: 10.1016/j.cclet.2023.108939

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(10)
HTML views(0)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Asymmetric construction of non-activated C-SCF3 stereocenter via copper-catalyzed hydroallylation of SCF3-alkenes

Metrics

通讯作者: 陈斌, bchen63@163.com

Asymmetric construction of non-activated C-SCF₃ stereocenter via copper-catalyzed hydroallylation of SCF₃-alkenes