Citation: Yaling Wang, Huiting Zhang, Yu Zhao, Mingyang Liu, Ming-Jie Yin, Quan-Fu An, Yansheng Li. In-situ photopolymerization hydrogel bioadhesive for on-demand rapid sealing of kidney wounds[J]. Chinese Chemical Letters, ;2026, 37(6): 111483. doi: 10.1016/j.cclet.2025.111483 shu

In-situ photopolymerization hydrogel bioadhesive for on-demand rapid sealing of kidney wounds

Yaling Wang ^{a, b, c} ,
Huiting Zhang ^{b, c} ,
Yu Zhao ^a ,
Mingyang Liu ^a ,
Ming-Jie Yin ^{b, c, *,} ,
Quan-Fu An ^{b, c} ,
Yansheng Li ^{a, *,}

a.
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
b.
Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemical Engineering, College of Materials Science and Engineering, Beijing University of Technology, Beijing 100124, China
c.
State Key Laboratory of Materials Low-Carbon Recycling, Beijing University of Technology, Beijing 100124, China

yinmj@bjut.edu.cn

lys-fast@163.com

Received Date: 14 April 2025
Revised Date: 15 June 2025
Accepted Date: 17 June 2025
Available Online: 17 June 2025

Figures(4)

Hydrogel bioadhesives, known for their ability to rapidly inhibit bleeding and minimize damage to surrounding tissues, are revolutionizing traditional surgical procedures. The interfacial force between hydrogel bioadhesives and tissue is critical for achieving strong adhesion in wound healing applications. However, preformed hydrogel bioadhesives cannot achieve seamless closure of irregular shape wounds and tend to detach in bleeding environments, limiting their practical applications. In this study, we developed an in-situ photopolymerization hydrogel bioadhesive (IPHB) method to fully seal irregular shape wounds in bleeding conditions within 5 min, eliminating the need for risky artery-blocking procedures. The fluidic hydrogel precursor solution can infiltrate micro- and nanostructured wound, penetrate tissues, and rapidly form an adhesive hydrogel under ultraviolet (UV) irradiation through strong topological entanglement at the interface. The resulting hydrogel demonstrates excellent stretchability, low swelling, and intrinsic antibacterial properties. The IPHB method was successfully employed to seal kidney wounds in a living pig, achieving rapid hemostasis and promoting wound healing without harming healthy tissues. This innovative approach significantly reduces surgical duration and enhances safety. Notably, this study marks the first application of a hydrogel bioadhesive for kidney wound treatment in a living pig, paving the way for safer and more efficient surgical practices.
- In-situ photopolymerization,
- Interface force,
- Hydrogel bioadhesive,
- Kidney cancer,
- Zwitterionic polymer
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