Citation: Rita Favas, Marta Monteiro, Hugo Almeida, Domingos Ferreira, Andreia Filipa Peixoto, Ana Catarina Silva. Marine bioactive compounds: Sustainable sources, green extraction, and healthcare applications[J]. Chinese Chemical Letters, ;2026, 37(6): 111482. doi: 10.1016/j.cclet.2025.111482 shu

Marine bioactive compounds: Sustainable sources, green extraction, and healthcare applications

Rita Favas ^{a, b} ,
Marta Monteiro ^c ,
Hugo Almeida ^{a, b, d} ,
Domingos Ferreira ^{a, b} ,
Andreia Filipa Peixoto ^c ,
Ana Catarina Silva ^{a, b, e, *,}

a.
UCIBIO, Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Porto 4050-313, Portugal
b.
Associate Laboratory i4HB Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto 4050-313, Portugal
c.
LAQV-REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto 4169-00, Portugal
d.
Mesosystem, Research & Investment by Spinpark, Guimarães 4805-017, Portugal
e.
FP-I3ID (Institute for Research, Innovation and Development), FP-BHS (Biomedical and Health Sciences Research Unit), Faculty of Health Sciences, University Fernando Pessoa, Porto 4249-004, Portugal

anacatsil@gmail.com

Received Date: 8 April 2025
Revised Date: 16 June 2025
Accepted Date: 17 June 2025
Available Online: 18 June 2025

Marine ecosystems represent one of the most valuable yet underexplored sources of diverse bioactive compounds with significant potential for economic, healthcare, and environmental applications. Marine-derived bioactive compounds have emerged as promising active ingredients, exhibiting antibacterial, antiviral, anticancer, anti-inflammatory, and antioxidant properties, among others, with growing use in cosmetics and food supplements. Ongoing research in this area is aligned with the United Nations Sustainable Development Goals, particularly Goal 12, which relates to responsible production and consumption. The environmentally friendly extraction of these bioactive compounds from marine sources offers a path toward greener industrial practices and a more sustainable global economy. This review provides a comprehensive overview of the current state of the art on the main classes of marine bioactive compounds, their natural sources, green extraction methods, and their applications in health-related fields, including cosmetics and food supplements. Despite their potential, the use of marine bioactive compounds remains limited. Current research is largely based on in vitro studies using compound mixtures, with limited data on regulatory frameworks and human safety. To unlock their full therapeutic potential, future research should focus on: the standardization of clinical trial protocols, the isolation and characterization of individual compounds, and the expansion of in vivo studies in both animals and humans.
- Marine bioactive compounds,
- Green extraction,
- Healthcare,
- Cosmetics,
- Food supplements,
- Sustainable
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沈阳化工大学材料科学与工程学院沈阳 110142