Citation: Ying Wang, Jiaqi Lv, Song Liang, Yingdong Xie, Yuan Tian, Dong Li, Hong-Ying Zang. Molecular iron-oxo clusters ameliorate sepsis via enhancing humoral immune response[J]. Chinese Chemical Letters, ;2025, 36(11): 111455. doi: 10.1016/j.cclet.2025.111455 shu

Molecular iron-oxo clusters ameliorate sepsis via enhancing humoral immune response

Ying Wang ^{a, b, c, 1} ,
Jiaqi Lv ^{b, d, 1} ,
Song Liang ^e ,
Yingdong Xie ^a ,
Yuan Tian ^f ,
Dong Li ^{a, *,} ,
Hong-Ying Zang ^{b, *,}

a.
Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China
b.
Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130022, China
c.
Department of Pharmacy, China-Japan Union Hospital of Jilin University, Jilin University, Changchun 130033, China
d.
School of Chemistry and Environmental Engineering, Jilin Provincial Science and Technology Innovation Center of Optical Materials and Chemistry, Jilin Provincial International Joint Research Center of Photo functional Materials and Chemistry, Changchun University of Science and Technology, Changchun 130022, China
e.
Key Laboratory of Bionic Engineering (Ministry of Education), College of Biological and Agricultural Engineering, Jilin University, Changchun 130021, China
f.
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, China

lidong1@jlu.edu.cn

zanghy100@nenu.edu.cn

Received Date: 3 April 2025
Revised Date: 10 June 2025
Accepted Date: 13 June 2025
Available Online: 13 June 2025

Figures(7)

Metal-based antimicrobial materials have been extensively studied and applied over decades. While these materials are notably characterized by their superior antibacterial performance and low propensity to induce drug resistance, critical limitations such as inherent cytotoxicity, poor solubility, and instability in aqueous solution remain significant challenges requiring systematic optimization. In this study, we synthesized water-soluble molecular iron-oxo clusters (MIC) with excellent biosafety and stability of aqueous solution. Our findings demonstrate that MIC exhibits marked therapeutic efficacy in cecal ligation and puncture induced sepsis models, a critical validation given sepsis' etiology as a life-threatening infection mediated systemic inflammatory syndrome. MIC combats bacteria by enhancing humoral immune responsiveness. MIC significantly improved the survival rate, reduced bacterial burden, stabilized body temperature, and modulated cytokine profiles in mice with sepsis. Further investigations revealed that MIC promotes B cells proliferation and oxidative phosphorylation, and mitigates mitochondrial damage and apoptosis in B cells, suggesting its role in modulating cellular metabolism. RNA sequencing analysis demonstrated that MIC exerts its effects by influencing key pathways involved in humoral immunity, inflammatory responses, and metabolic adaptation. These findings establish MIC as a novel therapeutic agent for regulating immune responses in sepsis, providing innovative strategies to improve recovery from this life-threatening condition.
- Sepsis,
- Molecular iron-oxo clusters,
- Immune modulation,
- Humoral immune response,
- Metal-based antibacterial materials
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