Citation: Li Song, Shuchun Bu, Yilan Ding, Pu Zhang, Ya-Qin Chai, Yingzi Fu, Ruo Yuan. Solvent-regulated mesoporous terbium-perylenetetracarboxylate metal organic framework with enhanced electrochemiluminescence for ultrasensitive cTnI bioanalysis[J]. Chinese Chemical Letters, ;2026, 37(5): 111454. doi: 10.1016/j.cclet.2025.111454 shu

Solvent-regulated mesoporous terbium-perylenetetracarboxylate metal organic framework with enhanced electrochemiluminescence for ultrasensitive cTnI bioanalysis

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China

fyzc@swu.edu.cn

yuanruo@swu.edu.cn

Received Date: 24 December 2024
Revised Date: 23 April 2025
Accepted Date: 13 June 2025
Available Online: 13 June 2025

Figures(5)

The typical organic perylenetetracarboxylate (PTC) luminophore suffers from limited bio-application due to its aggregation-caused quenching (ACQ) induced undesirable electrochemiluminescence (ECL) efficiency in aqueous solution. Herein, the ECL emission of PTC was highly improved through the ingenious coordination of PTC (ligand) with Tb³⁺ (metal ion) to prepare the Tb-PTC metal-organic framework (Tb-PTC MOF), which prevented the π-π stacking and the aggregation of PTC molecules in a homogeneous phase. Moreover, we found that the ECL emission of Tb-PTC MOF was further enhanced by regulating its morphology, pore size and electron transfer ability using different solvents during its synthesis procedure. Notably, under the mixture of DMF, EtOH, and H₂O (v/v/v, 1:1:1), a mesoporous Tb-PTC MOF exhibited an outstanding ECL intensity, which may be attributed to two reasons. Firstly, the mesopore and rough surface of Tb-PTC MOF (luminophore) provided abundant active sites and enlarged contact surfaces for S₂O₈^2– (coreactant). Secondly, Tb-PTC MOF with higher electron transfer ability could accelerate electron/hole recombination to enhance its ECL emission. Additionally, Tb-PTC MOF with excellent ECL performance was applied as a luminophore to fabricate an ultrasensitive ECL immunosensor for cardiac troponin Ⅰ (cTnI) detection, related to acute myocardial infarction. The constructed ECL immunosensor exhibited a satisfactory linear range (1 fg/mL − 20 ng/mL) and a low detection limit of 0.48 fg/mL. This study provides a new trend for the preparation of PTC-based nanomaterials with highly efficient ECL performance, broadening the scope for sensitive immunoassay in disease diagnosis.
- Electrochemiluminescence,
- Metal organic framework,
- Coordination-enhanced ECL,
- Solvent regulation,
- Cardiac troponin Ⅰ
1. [1]
  M.Z. Xi, Z.C. Wu, Z. Luo, et al., Angew. Chem. Int. Ed. 62 (2023) e202302166. doi: 10.1002/anie.202302166
2. [2]
  D.Y. Wang, X.W. Gao, J.N. Jia, et al., ACS Nano 17 (2023) 355–362. doi: 10.1021/acsnano.2c08474
3. [3]
  K.Y. Shen, J.L. Zhan, L. Shen, et al., Anal. Chem. 95 (2023) 4735–4743. doi: 10.1021/acs.analchem.2c05535
4. [4]
  N. Zhang, X.T. Wang, Z.P. Xiong, et al., Anal. Chem. 93 (2021) 17110–17118. doi: 10.1021/acs.analchem.1c04608
5. [5]
  M.M. Chen, H. Gao, Z.B. Ge, et al., J. Agric. Food Chem. 72 (2024) 2826–2833. doi: 10.1021/acs.jafc.3c08389
6. [6]
  Y.P. Li, X. Gao, Y.S. Fang, et al., Coord. Chem. Rev. 485 (2023) 215136. doi: 10.1016/j.ccr.2023.215136
7. [7]
  Y. Zhao, R.Z. Wang, Y.H. Wang, et al., Food Chem. 413 (2023) 135627. doi: 10.1016/j.foodchem.2023.135627
8. [8]
  Z.Y. Wang, J.B. Pan, Q. Li, et al., Adv. Funct. Mater. 30 (2020) 2000220. doi: 10.1002/adfm.202000220
9. [9]
  Y.Z. Shen, X. Gao, H.J. Lu, et al., Coord. Chem. Rev. 476 (2023) 214927.
10. [10]
  Y.G. Wang, G.H. Zhao, H. Chi, et al., J. Am. Chem. Soc. 143 (2021) 504–512. doi: 10.1021/jacs.0c12449
11. [11]
  A. Zanut, A. Fiorani, S. Canola, et al., Nat. Commun. 11 (2020) 2668. doi: 10.1038/s41467-020-16476-2
12. [12]
  Y.F. Wang, J.L. Ding, P. Zhou, et al., Angew. Chem. Int. Ed. 62 (2023) e202216525. doi: 10.1002/anie.202216525
13. [13]
  Y. Guo, Q.X. Zhou, J. Nan, et al., Nat. Commun. 13 (2022) 2067. doi: 10.1038/s41467-022-29826-z
14. [14]
  Y.J. Huang, J. Xing, Q.Y. Gong, et al., Nat. Commun. 10 (2019) 169. doi: 10.1038/s41467-018-08092-y
15. [15]
  Z.X. Lin, J.J. Richardson, J.J. Zhou, F. Caruso, Nat. Rev. Chem. 7 (2023) 273–286. doi: 10.1038/s41570-023-00474-1
16. [16]
  H.Y. Lin, Y.H. Yang, B.G. Diamond, et al., J. Am. Chem. Soc. 146 (2024) 1491–1500. doi: 10.1021/jacs.3c10917
17. [17]
  W.R. Cai, H.B. Zeng, H.G. Xue, et al., Anal. Chem. 92 (2020) 1916–1924. doi: 10.1021/acs.analchem.9b04104
18. [18]
  J. Zhong, X. Yuan, J. Xiong, et al., Environ. Res. 226 (2023) 115633. doi: 10.1016/j.envres.2023.115633
19. [19]
  L. He, W. Li, Z.W. Jiang, et al., Chem. Eng. J. 374 (2019) 1231–1240. doi: 10.1016/j.cej.2019.06.026
20. [20]
  P.P. Li, L. Luo, D. Cheng, et al., Anal. Chem. 94 (2022) 5707–5714. doi: 10.1021/acs.analchem.2c00737
21. [21]
  Y.C. Pi, Z.M. Qiu, Y. Fan, et al., Nano Lett. 24 (2024) 13760–13768. doi: 10.1021/acs.nanolett.4c04014
22. [22]
  Y. Yang, J.M. Wang, W.B. Liang, et al., Anal. Chem. 96 (2024) 16362–16369. doi: 10.1021/acs.analchem.4c03782
23. [23]
  L. Zhao, X.Z. Song, Y.Y. Li, et al., Biosens. Bioelectron. 221 (2023) 114925. doi: 10.1016/j.bios.2022.114925
24. [24]
  W.J. Dai, X.Y. Wang, G.X. Chen, et al., Chem. Eng. J. 465 (2023) 143037.
25. [25]
  H. Dong, L. Zhao, Y. Chen, et al., Anal. Chem. 94 (2022) 11940–11948. doi: 10.1021/acs.analchem.2c02898
26. [26]
  Y.F. Chen, Y.Z. Guo, S. Xiao, et al., Anal. Chem. 96 (2024) 4589–4596. doi: 10.1021/acs.analchem.3c05517
27. [27]
  X.W. Du, X.J. Su, W.X. Zhang, et al., Anal. Chem. 94 (2022) 442–463. doi: 10.1021/acs.analchem.1c04476
28. [28]
  Y.Q. Zhao, A.J. Zhao, Z.Z. Wang, et al., Anal. Chem. 95 (2023) 11687–11694. doi: 10.1021/acs.analchem.3c01647
29. [29]
  S.G. Li, H.Y. Zhang, M. Zhu, et al., Chem. Rev. 123 (2023) 7953–8039. doi: 10.1021/acs.chemrev.1c00759
30. [30]
  X.F. Tang, Y.P. Zhu, W.J. Guan, et al., Life Sci. 305 (2022) 120733. doi: 10.1016/j.lfs.2022.120733
31. [31]
  F. Liu, G. Ding, Z. Zheng, et al., Chem. Eng. J. 429 (2022) 132377. doi: 10.1016/j.cej.2021.132377
32. [32]
  G. Valente, M. Esteve-Rochina, S.P.C. Alves, et al., Inorg. Chem. 62 (2023) 7834–7842. doi: 10.1021/acs.inorgchem.3c00540
33. [33]
  G. Valente, M. Esteve-Rochina, A. Paracana, et al., Mol. Syst. Des. Eng. 7 (2022) 1065–1072. doi: 10.1039/d2me00108j
34. [34]
  H. Gao, X. Wei, M.Z. Li, et al., Small 17 (2021) 2103424.
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