Citation: Yizhi Ge, Jiahui Zou, Hui Liu, Wei He, Huanfeng Zhu. Cisplatin-polyphenol complex liposomes reduce chemotherapy toxicity[J]. Chinese Chemical Letters, ;2026, 37(1): 111450. doi: 10.1016/j.cclet.2025.111450 shu

Cisplatin-polyphenol complex liposomes reduce chemotherapy toxicity

Yizhi Ge ^{a, 1} ,
Jiahui Zou ^{b, 1} ,
Hui Liu ^{b, 1} ,
Wei He ^{b, *,} ,
Huanfeng Zhu ^{a, *,}

a.
Department of Radiation Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, China
b.
School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China

weihe@cpu.edu.cn

zhuhuanf@njmu.edu.cn

Received Date: 10 April 2025
Revised Date: 11 June 2025
Accepted Date: 12 June 2025
Available Online: 12 June 2025

Figures(6)

Cisplatin (CDDP)-based chemotherapy is an effective strategy for the treatment of advanced nasopharyngeal carcinoma (NPC). However, serious toxic side effects of CDDP limit patient tolerance and treatment compliance, which urgently needs to be addressed in clinical application. Liposomes have been considered ideal vehicles for reducing CDDP toxicity due to their high biocompatibility, low toxicity and passive targeting ability. Nevertheless, CDDP's poor water/lipid solubility usually results in a low liposome drug-lipid ratio, limiting tumor delivery ability. Herein, a CDDP-polyphenol complex liposome was designed to increase the drug loading capacity of CDDP to realize the reduction of toxicity and effective antitumor effect simultaneously. The complex was prepared via complexation reaction of different stoichiometric ratios of CDDP and polyphenolic substances (gallic acid, epigallocatechin gallate and tannic acid), followed by encapsulation of complex in liposomes to improve tumor targeting. Notably, the molecular interaction forces between CDDP and polyphenolic substances were intensively investigated through a binding force disruption assay. In vitro studies demonstrated that the optimal formulation of CDDP-epigallocatechin gallate complex liposome (CDDP-EGCG Lips) showed the highest CDDP encapsulation efficiency, favorable stability, pH-sensitive release, enhanced cellular uptake and apoptosis effect. In vivo studies revealed that CDDP-EGCG Lips retarded the elimination of CDDP to prolong their circulation time, inhibited the growth of tumors, and significantly reduced the toxic side effects compared to CDDP monotherapy. This delivery strategy holds great promise for improving the clinical use of platinum-based drugs.
- Cisplatin,
- Polyphenolic substances,
- CDDP-polyphenol complex,
- Liposome,
- Toxic side effect
1. [1]
  K.C. Wong, E.P. Hui, K.W. Lo, et al., Nat. Rev. Clin. Oncol. 18 (2021) 679–695.
2. [2]
  H. Wang, T. Fan, Y. Lu, et al., Int. J. Cancer 157 (2025) 239–250.
3. [3]
  L. Xie, F. Shi, Y. Li, et al., Signal. Transduct. Target. 5 (2020) 56.
4. [4]
  U. Anand, A. Dey, A.K.S. Chandel, et al., Genes. Dis. 10 (2023) 1367–1401.
5. [5]
  N. Riaz, E. Sherman, L. Koutcher, et al., Am. J. Clin. Oncol. Canc. 39 (2016) 27–31.
6. [6]
  A. Lee, J.C. Chow, N.Y. Lee, JAMA Oncol. 7 (2021) 445–453.
7. [7]
  R. Liu, C. Luo, Z. Pang, et al., Chin. Chem. Lett. 34 (2023) 107518.
8. [8]
  X. Li, Y. Lai, G. Wan, et al., Chin. J. Nat. Med. 22 (2024) 1100–1116.
9. [9]
  S. Dadashzadeh, N. Mirahmadi, M. Babaei, et al., J. Control. Release 148 (2010) 177–186.
10. [10]
  X. Li, J. Gu, Q. Xiao, et al., Chin. Chem. Lett. 34 (2023) 107483.
11. [11]
  X. Wang, C. Li, Y. Wang, et al., Acta Pharm. Sin. B 12 (2022) 4098–4121.
12. [12]
  J.A. Santos, D. Silva, M.P.M. Marques, Nanoscale 16 (2024) 14640–14686.
13. [13]
  H. Liu, J. Zou, X. Li, Y. Ge, W. He, J. Control. Release 380 (2025) 503–523.
14. [14]
  M. Abbas, F. Saeed, F.M. Anjum, et al., Int. J. Food. Prop. 20 (2017) 1689–1699.
15. [15]
  B. Li, C. Teng, H. Yu, et al., Acta Pharm. Sin. B 13 (2023) 2369–2382.
16. [16]
  H. Geng, Q. Zhong, J. Li, et al., Chem. Rev. 122 (2022) 11432–11473.
17. [17]
  K.T. Magar, G.F. Boafo, M. Zoulikha, et al., Chin. Chem. Lett. 34 (2023) 107453.
18. [18]
  J. Xiang, Y. Li, Y. Zhang, et al., J. Control. Release 330 (2021) 992–1003.
19. [19]
  X. Zhang, Z. Li, P. Yang, et al., Mater. Horiz. 8 (2021) 145–167.
20. [20]
  Y. Guo, Q. Sun, F.G. Wu, et al., Adv. Mater. 33 (2021) 2007356.
21. [21]
  X. Wang, Z. Guo, Chem. Soc. Rev. 42 (2013) 202–224.
22. [22]
  Y. Chen, C. Chen, X. Zhang, et al., Acta Pharm. Sin. B 10 (2020) 1106–1121.
23. [23]
  Y. Dai, S. Cheng, Z. Wang, et al., ACS Nano 12 (2018) 455–463.
24. [24]
  Z. Ren, S. Sun, R. Sun, et al., Adv. Mater. 32 (2020) 1906024.
25. [25]
  L. Chen, T. Liu, C. a. Ma, J. Phys. Chem. A 114 (2010) 443–454.
26. [26]
  W. Xie, Z. Zhang, Y. Gao, J. Phys. Chem. B 120 (2016) 2343–2351.
27. [27]
  X. Xin, H. Zhang, G. Xu, et al., Colloid. Surface. A 418 (2013) 60–67.
28. [28]
  C. Xin, J. Chen, H. Liang, et al., Carbohyd. Polym. 174 (2017) 337–342.
29. [29]
  Z. Zhang, L. Xie, Y. Ju, et al., Small 17 (2021) 2100314.
30. [30]
  J. Peng, T. Qi, J. Liao, et al., Biomaterials 34 (2013) 8726–8740.
31. [31]
  J. Xiang, Y. Zhang, X. Liu, et al., Nano Lett. 22 (2022) 5615–5625.
32. [32]
  C.J. Greenhalgh, E. Karekla, G.J. Miles, et al., Anal. Chem. 92 (2020) 9847–9855.
33. [33]
  N. Rani, K. Rawat, M. Saini, et al., ACS Omega 8 (2023) 14509–14519.
34. [34]
  X. Chen, F. Meng, Y. Xu, et al., Nat. Commun. 14 (2023) 4584.
35. [35]
  H. Ding, P. Tan, S. Fu, et al., J. Control. Release 348 (2022) 206–238.
36. [36]
  Y. Park, S. Kwon, G. Lee, et al., J. Control. Release 330 (2021) 1–14.
1. [1]
  Huiyang Chen , Zibo Li , Xiaoying Li , Chenhong Tang , Xiaoyu Liu , Minyi Nie , Ying Huang , Xiaoyu Chen , Kuncai Liu , Yilan Dai , Qiaoling Zhang , Ling Lin , Siming Zhang , Bingchen Zhang , Zhiqiang Yu . A novel mitochondria-targeted nanoprodrug amplifies oxidative stress to enhance cisplatin chemotherapy for the treatment of hepatocellular carcinoma. Chinese Chemical Letters, 2025, 36(10): 111313-. doi: 10.1016/j.cclet.2025.111313
2. [2]
  Cheng-Zhe Gao , Hao-Ran Jia , Tian-Yu Wang , Xiao-Yu Zhu , Xiaofeng Han , Fu-Gen Wu . A dual drug-loaded tumor vasculature-targeting liposome for tumor vasculature disruption and hypoxia-enhanced chemotherapy. Chinese Chemical Letters, 2025, 36(1): 109840-. doi: 10.1016/j.cclet.2024.109840
3. [3]
  Yulin Chen , Guangchao Wang , Fengjin Zhou , Zhifeng Yin , Fuming Shen , Weizong Weng , Hao Zhang , Yingying Jiang , Xinru Liu , Yonghui Deng , Yuan Chen , Ke Xu , Jiacan Su . Targeting TRPA1 with liposome-encapsulated drugs anchored to microspheres for effective osteoarthritis treatment. Chinese Chemical Letters, 2025, 36(5): 110053-. doi: 10.1016/j.cclet.2024.110053
4. [4]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
5. [5]
  Han Han , Bi-Te Chen , Jia-Rong Ding , Jin-Ming Si , Tian-Jiao Zhou , Yi Wang , Lei Xing , Hu-Lin Jiang . A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy. Chinese Chemical Letters, 2024, 35(10): 109583-. doi: 10.1016/j.cclet.2024.109583
6. [6]
  Cheng Cheng , Nasir Ali , Ji Liu , Juan Qiao , Ming Wang , Li Qi . Construction of degradable liposome-templated microporous metal-organic frameworks with commodious space for enzymes. Chinese Chemical Letters, 2024, 35(11): 109812-. doi: 10.1016/j.cclet.2024.109812
7. [7]
  Huijiao Fu , Peiqin Liang , Qianwen Chen , Yan Wang , Guang Li , Xuzi Cai , Shengtao Wang , Kun Chen , Shengying Shi , Zhiqiang Yu , Xuefeng Wang . COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer: An allicin-based nanomedicine approach. Chinese Chemical Letters, 2024, 35(8): 109241-. doi: 10.1016/j.cclet.2023.109241
8. [8]
  Ying Chen , Lun Li , Guohao Han , Ren Liu , Guanghui An , Yi Zhu . Macromolecular coumarin sulfonium salt with side chain effect constructed by copolymerization strategy for free radical, cationic, and hybrid photopolymerizations. Chinese Chemical Letters, 2025, 36(7): 110458-. doi: 10.1016/j.cclet.2024.110458
9. [9]
  Linjie Ju , Zhongxi Huang , Qian Shen , Chan Fu , Shuanghe Li , Wenjie Duan , Chenfeng Xu , Weizhen An , Zhiqiang Zhai , Jifu Wei , Changmin Yu , Guoren Zhou . Glutathione depletion based Pt(Ⅳ) hybrid mesoporous organosilica delivery system to conquer cisplatin chemoresistance: A “one stone three birds” strategy. Chinese Chemical Letters, 2024, 35(10): 109450-. doi: 10.1016/j.cclet.2023.109450
10. [10]
  Beitong Zhu , Xiaorui Yang , Lirong Jiang , Tianhong Chen , Shuangfei Wang , Lintao Zeng . A portable and versatile fluorescent platform for high-throughput screening of toxic phosgene, diethyl chlorophosphate and volatile acyl chlorides. Chinese Chemical Letters, 2025, 36(1): 110222-. doi: 10.1016/j.cclet.2024.110222
11. [11]
  Yu ZHANG , Fangfang ZHAO , Cong PAN , Peng WANG , Liangming WEI . Application of double-side modified separator with hollow carbon material in high-performance Li-S battery. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1218-1232. doi: 10.11862/CJIC.20230412
12. [12]
  Supphachok Chanmungkalakul , Syed Ali Abbas Abedi , Federico J. Hernández , Jianwei Xu , Xiaogang Liu . The dark side of cyclooctatetraene (COT): Photophysics in the singlet states of “self-healing” dyes. Chinese Chemical Letters, 2024, 35(8): 109227-. doi: 10.1016/j.cclet.2023.109227
13. [13]
  Yao HUANG , Yingshu WU , Zhichun BAO , Yue HUANG , Shangfeng TANG , Ruixue LIU , Yancheng LIU , Hong LIANG . Copper complexes of anthrahydrazone bearing pyridyl side chain: Synthesis, crystal structure, anticancer activity, and DNA binding. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 213-224. doi: 10.11862/CJIC.20240359
14. [14]
  Ruixiang Fang , Yilan Zhai , Huijuan Bi , Caixuan Wang , Ailing Tang , Shiming Zhang , Zhixiang Wei , Kun Lu . Enhancing photovoltaic performance via γ-positioned side-chains engineering of Y-series non-fullerene acceptors. Chinese Chemical Letters, 2026, 37(1): 111787-. doi: 10.1016/j.cclet.2025.111787
15. [15]
  Dong Cheng , Youyou Feng , Bingxi Feng , Ke Wang , Guoxin Song , Gen Wang , Xiaoli Cheng , Yonghui Deng , Jing Wei . Polyphenol-mediated interfacial deposition strategy for supported manganese oxide catalysts with excellent pollutant degradation performance. Chinese Chemical Letters, 2024, 35(5): 108623-. doi: 10.1016/j.cclet.2023.108623
16. [16]
  Peizhe Li , Qiaoling Liu , Mengyu Pei , Yuci Gan , Yan Gong , Chuchen Gong , Pei Wang , Mingsong Wang , Xiansong Wang , Da-Peng Yang , Bo Liang , Guangyu Ji . Chlorogenic acid supported strontium polyphenol networks ensemble microneedle patch to promote diabetic wound healing. Chinese Chemical Letters, 2024, 35(8): 109457-. doi: 10.1016/j.cclet.2023.109457
17. [17]
  Yue Ren , Kang Li , Yi-Zi Wang , Shao-Peng Zhao , Shu-Min Pan , Haojie Fu , Mengfan Jing , Yaming Wang , Fengyuan Yang , Chuntai Liu . Swelling and erosion assisted sustained release of tea polyphenol from antibacterial ultrahigh molecular weight polyethylene for joint replacement. Chinese Chemical Letters, 2025, 36(2): 110468-. doi: 10.1016/j.cclet.2024.110468
18. [18]
  Yanjun Cai , Yong Jiang , Yu Chen , Erzhuo Cheng , Yuan Gu , Yuwei Li , Qianqian Liu , Jian Zhang , Jifang Liu , Shisong Han , Bin Yang . Amplifying STING activation and immunogenic cell death by metal-polyphenol coordinated nanomedicines for enhanced cancer immunotherapy. Chinese Chemical Letters, 2025, 36(5): 110437-. doi: 10.1016/j.cclet.2024.110437
19. [19]
  Xueying Shi , Xiaoxuan Zhou , Bing Xiao , Hongxia Xu , Wei Zhang , Hongjie Hu , Shiqun Shao , Zhuxian Zhou , Youqing Shen , Xiaodan Xu , Jianbin Tang . A β-lapachone-loaded iron-polyphenol nanocomplex enhances chemodynamic therapy through cascade amplification of ROS in tumor. Chinese Chemical Letters, 2025, 36(5): 110178-. doi: 10.1016/j.cclet.2024.110178
20. [20]
  Fanxin Kong , Hongzhi Wang , Huimei Duan . Inhibition effect of sulfation on Pt/TiO2 catalysts in methane combustion. Chinese Journal of Structural Chemistry, 2024, 43(5): 100287-100287. doi: 10.1016/j.cjsc.2024.100287

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(5)
HTML views(1)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142