Citation: Wenting Wu, Zhao Chen, Man Zhe, Peiyun Yu, Sujan Shakya, Fei Xing, Ulrike Ritz. Engineered stimuli-responsive MOFs: Toward intelligent drug delivery systems for precision biomedicine[J]. Chinese Chemical Letters, ;2026, 37(6): 111448. doi: 10.1016/j.cclet.2025.111448 shu

Engineered stimuli-responsive MOFs: Toward intelligent drug delivery systems for precision biomedicine

Wenting Wu ^{a, 1} ,
Zhao Chen ^{b, 1} ,
Man Zhe ^c ,
Peiyun Yu ^d ,
Sujan Shakya ^b ,
Fei Xing ^{a, *,} ,
Ulrike Ritz ^{e, *,}

a.
Department of Pediatric Surgery, Division of Orthopedic Surgery, Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Department of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China
c.
Animal Experiment Center, West China Hospital, Sichuan University, Chengdu 610041, China
d.
LIMES Institute, Department of Molecular Brain Physiology and Behavior, University of Bonn, Bonn 53115, Germany
e.
Department of Orthopedics and Traumatology, Biomatics Group, University Medical Center of the Johannes Gutenberg University, Mainz 55131, Germany

xingfeihuaxi@163.com

ritz@uni-mainz.de

Received Date: 27 March 2025
Revised Date: 6 June 2025
Accepted Date: 11 June 2025
Available Online: 11 June 2025

Figures(7)

Nanotechnological advancements have established stimuli-responsive nanomaterials as a pivotal strategy for spatiotemporally controlled drug delivery in precision biomedicine. Metal-organic frameworks (MOFs), crystalline porous materials constructed from metal ions/clusters and organic ligands through coordination bonds, exhibit exceptional drug delivery potential owing to their high surface area, tunable pore size, and facile functionalization. This review systematically analyzes recent advances in MOF-based drug delivery, with a focus on synthesis strategies, stimulus-responsive mechanisms, and biomedical applications. A key contribution of this review is the systematic classification of stimuli-responsive mechanisms, covering triggers such as pH, temperature, magnetic fields, humidity, and biological stimuli (e.g., redox factors, enzymes, adenosine triphosphate (ATP), ions, and hydrogen sulfide (H₂S)). This framework provides a blueprint for designing targeted drug delivery platforms. By synthesizing cutting-edge research and emerging trends, this review offers actionable insights to advance stimuli-responsive MOF drug delivery systems (DDS).
- MOFs,
- Nanomaterials,
- Drug delivery,
- Stimuli-responsive,
- Control release
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