Citation: Ji-Pan Dong, Lei Zhang, Yi-Fei Hu, Mo Sun, Jun-Li Hou. Artificial transmembrane channels displaying mechanosensitivity[J]. Chinese Chemical Letters, ;2026, 37(3): 111420. doi: 10.1016/j.cclet.2025.111420 shu

Artificial transmembrane channels displaying mechanosensitivity

Department of Chemistry, Fudan University, Shanghai 200433, China

mosun@fudan.edu.cn

houjl@fudan.edu.cn

Received Date: 20 March 2025
Revised Date: 16 May 2025
Accepted Date: 6 June 2025
Available Online: 6 June 2025

Figures(7)

Mechanosensitive channel proteins serve important physiological functions in biological systems. Building artificial transmembrane channels to mimic the function of natural channels would provide a new strategy for treating channel-related diseases. In this paper, we describe the design and construction of artificial channels derived from pillar[5]arene backbones with different flexibilities, which are determined by the alkyl chain length. Importantly, the ion transport activities of the channels can be activated by increasing the membrane curvature and tension, which endows the channel with mechano-gating behavior.
- Artificial channel,
- Mechanosensitive,
- Pillar[5]arene,
- Ion transport,
- Membrane tension,
- Membrane curvature
1. [1]
  O.P. Hamill, B. Martinac, Physiol. Rev. 81 (2001) 685–740. doi: 10.1152/physrev.2001.81.2.685
2. [2]
  F. Guharay, F. Sachs, J. Physiol. London. 352 (1984) 685–701. doi: 10.1113/jphysiol.1984.sp015317
3. [3]
  M. Chalfie, Nat. Rev. Mol. Cell Biol. 10 (2009) 44–52. doi: 10.1038/nrm2595
4. [4]
  P.G. Gillespie, R.G. Walker, Nature 413 (2001) 194–202. doi: 10.1038/35093011
5. [5]
  F.M. Ashcroft, Epithelial Na+ channel, in: F.M. Ashcroft (Ed.), Ion Channels and Disease, Academic Press, 2000, pp. 231–247.
6. [6]
  J. Yang, G.C. Yu, J.L. Sessler, et al., Chem 7 (2021) 3256–3291. doi: 10.1016/j.chempr.2021.10.028
7. [7]
  G.W. Gokel, S. Negin, Acc. Chem. Res. 46 (2013) 2824–2833. doi: 10.1021/ar400026x
8. [8]
  S. Ren, Z. Zhang, Z. Dong, Trends Chem. 6 (2024) 726–738. doi: 10.1016/j.trechm.2024.10.005
9. [9]
  L. Mao, S. Hou, L. Shi, et al., Chem. Sci. 16 (2025) 371–377. doi: 10.1039/d4sc06893a
10. [10]
  Z. Zheng, X. Wei, Y. Lin, et al., J. Nanobiotechnol. 22 (2024) 29. doi: 10.47297/wspciwsp2516-252706.20240805
11. [11]
  S.P. Zheng, L.B. Huang, Z.H. Sun, M. Barboiu, Angew. Chem. Int. Ed. 60 (2021) 566–597. doi: 10.1002/anie.201915287
12. [12]
  S. Matile, T. Fyles, Acc. Chem. Res. 46 (2013) 2741–2742. doi: 10.1021/ar400234d
13. [13]
  Y. Zhao, H.K. Cho, L. Widanapathirana, S.Y. Zhang, Acc. Chem. Res. 46 (2013) 2763–2772. doi: 10.1021/ar300337f
14. [14]
  J. Montenegro, M.R. Ghadiri, J.R. Granja, Acc. Chem. Res. 46 (2013) 2955–2965. doi: 10.1021/ar400061d
15. [15]
  X. Li, Y.D. Wu, D. Yang, Acc. Chem. Res. 41 (2008) 1428–1438. doi: 10.1021/ar8001393
16. [16]
  N. Sakai, S. Matile, Langmuir 29 (2013) 9031–9040. doi: 10.1021/la400716c
17. [17]
  B. Wu, Y. Yan, Y. Zhu, et al., Giant 22 (2025) 100352. doi: 10.1016/j.giant.2025.100352
18. [18]
  Y. Lin, B. Wu, Y. Zeng, et al., Angew. Chem. Int. Ed. 63 (2024) e202408558. doi: 10.1002/anie.202408558
19. [19]
  T.G. Johnson, M.J. Langton, J. Am. Chem. Soc. 145 (2023) 27167–27184. doi: 10.1021/jacs.3c08877
20. [20]
  H.W. Ma, R.J. Ye, L. Jin, et al., Chin. Chem. Lett. 34 (2023) 108355. doi: 10.1016/j.cclet.2023.108355
21. [21]
  Y.W. Li, Y.H. Fu, J.L. Hou, Chin. J. Chem. 40 (2022) 1293–1297. doi: 10.1002/cjoc.202100836
22. [22]
  S.W. Qi, J. Tian, J. Zhang, et al., CCS Chem. 4 (2021) 1850–1857.
23. [23]
  A.P. Davis, D.N. Sheppard, B.D. Smith, Chem. Soc. Rev. 36 (2007) 348–357. doi: 10.1039/B512651G
24. [24]
  L. Zhang, J. Tian, Z. Lin, Z. Dong, J. Am. Chem. Soc. 146 (2024) 8500–8507. doi: 10.1021/jacs.3c14736
25. [25]
  J.F. Lin, X.D. Wang, Y.F. Ao, Q.Q. Wang, D.X. Wang, Angew. Chem. Int. Ed. 63 (2024) e202411702. doi: 10.1002/anie.202411702
26. [26]
  J. Zhu, X.D. Wang, J. Luo, et al., Org. Biomol. Chem. 19 (2021) 8586–8590. doi: 10.1039/d1ob01617b
27. [27]
  B. Ren, Y. Sun, P. Xin, ChemPlusChem 89 (2024) e202400466. doi: 10.1002/cplu.202400466
28. [28]
  L. Shi, W. Zhao, Z. Jiu, et al., Angew. Chem. Int. Ed. 63 (2024) e202403667. doi: 10.1002/anie.202403667
29. [29]
  D.D. Su, M. Barboiu, CCS Chem. 5 (2022) 279–291.
30. [30]
  L. Zhang, Y.G. Cao, T. Fan, et al., Chin. J. Chem. 42 (2024) 1335–1340. doi: 10.1002/cjoc.202300736
31. [31]
  Y.X. Shen, W. Si, M. Erbakan, et al., Proc. Natl. Acad. Sci. U. S. A. 112 (2015) 9810–9815. doi: 10.1073/pnas.1508575112
32. [32]
  Z.J. Yan, D.D. Wang, Z.J. Ye, et al., J. Am. Chem. Soc. 142 (2020) 15638–15643. doi: 10.1021/jacs.0c00601
33. [33]
  H.Q. Zhao, S. Sheng, Y.H. Hong, H.Q. Zeng, J. Am. Chem. Soc. 136 (2014) 14270–14276. doi: 10.1021/ja5077537
34. [34]
  J.Y. Chen, Q. Xiao, H. Behera, J.L. Hou, Chin. Chem. Lett. 31 (2020) 77–80. doi: 10.1016/j.cclet.2019.05.009
35. [35]
  H.K. Cho, L. Widanapathirana, Y. Zhao, J. Am. Chem. Soc. 133 (2011) 141–147. doi: 10.1021/ja109036z
36. [36]
  L. Chen, W. Si, L. Zhang, et al., J. Am. Chem. Soc. 135 (2013) 2152–2155. doi: 10.1021/ja312704e
37. [37]
  J.Y. Chen, J.L. Hou, Org. Chem. Front. 5 (2018) 1728–1736. doi: 10.1039/c8qo00287h
38. [38]
  Y. Zhou, Y. Chen, P.P. Zhu, et al., Chem. Commun. 53 (2017) 3681–3684. doi: 10.1039/C7CC01123G
39. [39]
  W.Z. Wang, L.B. Huang, S.P. Zheng, et al., J. Am. Chem. Soc. 143 (2021) 15653–15660. doi: 10.1021/jacs.1c05750
40. [40]
  H. Yang, J. Yi, S. Pang, et al., Angew. Chem. Int. Ed. 61 (2022) e202204605. doi: 10.1002/anie.202204605
41. [41]
  V. García-López, F. Chen, L.G. Nilewski, et al., Nature 548 (2017) 567–572. doi: 10.1038/nature23657
42. [42]
  T. Muraoka, D. Noguchi, R.S. Kasai, et al., Nat. Commun. 11 (2020) 2924. doi: 10.1038/s41467-020-16770-z
43. [43]
  X.Y. Hu, N.N. Liu, H.S. Yang, et al., Chem. Commun. 55 (2019) 3008–3011. doi: 10.1039/c9cc00732f
44. [44]
  H.C. Zhang, X. Hou, L. Zeng, et al., J. Am. Chem. Soc. 135 (2013) 16102–16110. doi: 10.1021/ja4037669
45. [45]
  W.H. Chen, M. Nishikawa, S.D. Tan, et al., Chem. Commun. (2004) 872–873.
46. [46]
  S. Chen, Y. Wang, T. Nie, et al., J. Am. Chem. Soc. 140 (2018) 17992–17998. doi: 10.1021/jacs.8b09580
47. [47]
  Z.J. Yan, Y.W. Li, M.H. Yang, et al., J. Am. Chem. Soc. 143 (2021) 11332–11336. doi: 10.1021/jacs.1c06000
48. [48]
  S.P. Zheng, J.J. Jiang, A. Van Der Lee, M. Barboiu, Angew. Chem. Int. Ed. 59 (2020) 18920–18926. doi: 10.1002/anie.202008393
49. [49]
  C. Goto, M. Yamamura, A. Satake, Y. Kobuke, J. Am. Chem. Soc. 123 (2001) 12152–12159. doi: 10.1021/ja010761h
50. [50]
  K. Sato, R. Sasaki, R. Matsuda, et al., J. Am. Chem. Soc. 144 (2022) 11802–11809. doi: 10.1021/jacs.2c04118
51. [51]
  M. Macchione, M. Tsemperouli, A. Goujon, et al., Helv. Chim. Acta 101 (2018) e1800014. doi: 10.1002/hlca.201800014
52. [52]
  T. Muraoka, K. Umetsu, K.V. Tabata, et al., J. Am. Chem. Soc. 139 (2017) 18016–18023. doi: 10.1021/jacs.7b09515
53. [53]
  Y.Q. Wu, Q.Q. Xu, Y.X. Chen, et al., Adv. Mater. 37 (2025) 2416852. doi: 10.1002/adma.202416852
54. [54]
  C. Park, K.T. Kim, Chin. J. Chem. 33 (2015) 311–318. doi: 10.1002/cjoc.201400875
55. [55]
  H. Behera, L. Yang, J.L. Hou, Chin. J. Chem. 38 (2020) 215–217. doi: 10.1002/cjoc.201900408
56. [56]
  S. Fa, T. Kakuta, T. Yamagishi, T. Ogoshi, CCS Chem. 1 (2019) 50–63. doi: 10.31635/ccschem.019.20180014
57. [57]
  T. Ogoshi, S. Kanai, S. Fujinami, T.A. Yamagishi, Y. Nakamoto, J. Am. Chem. Soc. 130 (2008) 5022–5023. doi: 10.1021/ja711260m
58. [58]
  T. Ogoshi, T. Yamagishi, Y. Nakamoto, Chem. Rev. 116 (2016) 7937–8002. doi: 10.1021/acs.chemrev.5b00765
59. [59]
  Q.Y. Huan, T. Lin, Y.H. Fu, J.L. Hou, Chin. Chem. Lett. 35 (2024) 108566. doi: 10.1016/j.cclet.2023.108566
60. [60]
  W. Si, P.Y. Xin, Z.T. Li, J.L. Hou, Acc. Chem. Res. 48 (2015) 1612–1619. doi: 10.1021/acs.accounts.5b00143
61. [61]
  Y.H. Fu, Y.F. Hu, T. Lin, et al., Nat. Chem. 16 (2024) 1418–1426. doi: 10.1038/s41557-024-01519-8
62. [62]
  Q. Xiao, T. Fan, Y.L. Wang, et al., CCS Chem. 5 (2023) 1745–1752. doi: 10.31635/ccschem.023.202302975
63. [63]
  Q. Xiao, D.M. Guan, Y.H. Fu, et al., J. Am. Chem. Soc. 146 (2024) 22869–22873. doi: 10.1021/jacs.4c05959
64. [64]
  M. Zhang, P.P. Zhu, P.Y. Xin, et al., Angew. Chem. Int. Ed. 56 (2017) 2999–3003. doi: 10.1002/anie.201612093
65. [65]
  P. Xin, H. Yuan, L. Zhang, et al., J. Mater. Chem. B 12 (2024) 10835–10838. doi: 10.1039/d4tb01508h
66. [66]
  M.J. Thompson, J.E. Baenziger, Nat. Chem. Biol. 16 (2020) 1331–1342. doi: 10.1038/s41589-020-00693-3
67. [67]
  E. Abel, G.E.M. Maguire, O. Murillo, et al., J. Am. Chem. Soc. 121 (1999) 9043–9052. doi: 10.1021/ja9909172
68. [68]
  M. Ueki, M. Iwamoto, FEBS Lett. 595 (2021) 1914–1919. doi: 10.1002/1873-3468.14141
69. [69]
  X.J. Zhang, Z.F. Liu, J. Li, Protein Sci. 25 (2016) 1954–1964. doi: 10.1002/pro.3017
70. [70]
  H.R. Zheng, H.D. Li, M.Q. Li, et al., Angew. Chem. Int. Ed. 62 (2023) e202305896. doi: 10.1002/anie.202305896
71. [71]
  L.T. Yan, X.B. Yu, Nanoscale 3 (2011) 3812–3818. doi: 10.1039/c1nr10446b
72. [72]
  J. Schrenzel, N. Demaurex, M. Foti, et al., Biophys. J. 69 (1995) 2378–2391. doi: 10.1016/S0006-3495(95)80107-4
73. [73]
  L.B. Huang, D.D. Su, A. Hardiagon, et al., J. Am. Chem. Soc. 147 (2024) 678–686. doi: 10.1111/ijlh.14272
74. [74]
  B. Martinac, N. Bavi, P. Ridone, et al., Biophys. Rev. 10 (2018) 1377–1384. doi: 10.1007/s12551-018-0450-3
75. [75]
  J.K.W. Chui, T.M. Fyles, Chem. Soc. Rev. 41 (2012) 148–175. doi: 10.1039/C1CS15099E
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  Bingbing Shi , Yuchun Wang , Yi Zhou , Xing-Xing Zhao , Yizhou Li , Nuoqian Yan , Wen-Juan Qu , Qi Lin , Tai-Bao Wei . A supramolecular oligo[2]rotaxane constructed by orthogonal platinum(Ⅱ) metallacycle and pillar[5]arene-based host–guest interactions. Chinese Chemical Letters, 2024, 35(10): 109540-. doi: 10.1016/j.cclet.2024.109540
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  Xintian Qu , Zeen Liu , Zhifan Wang , Dongyan Yu , Xueqiu Huang , Jie Yang , Jiecheng Ji , Xueqin Wei , Cheng Yang . Achieving strong and tunable circularly polarized luminescence through pillar[5]arenes insertion in BINOL-Py-based chromophore. Chinese Chemical Letters, 2025, 36(11): 111024-. doi: 10.1016/j.cclet.2025.111024
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