Citation: Jun Huang, Jiangping Qin, Caijin Ban, Jingmei Yuan, Jing Yang, Guoping Yang. Visible-light induced cascade sulfonation/cyclization reaction in water towards sulfonated dihydroisoquinolino[1,2-b]quinazolinones[J]. Chinese Chemical Letters, ;2026, 37(2): 111379. doi: 10.1016/j.cclet.2025.111379 shu

Visible-light induced cascade sulfonation/cyclization reaction in water towards sulfonated dihydroisoquinolino[1,2-b]quinazolinones

Jun Huang ^a ,
Jiangping Qin ^a ,
Caijin Ban ^a ,
Jingmei Yuan ^{a, *,} ,
Jing Yang ^{a, *,} ,
Guoping Yang ^{b, *,}

a.
Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, College of Chemistry and Materials, Nanning Normal University, Nanning 530001, China
b.
Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, School of Chemistry and Materials Science, East China University of Technology, Nanchang 330013, China

yuanjm9@nnnu.edu.cn

yangjing1512f@nnnu.edu.cn

erick@ecut.edu.cn

Received Date: 7 April 2025
Revised Date: 13 May 2025
Accepted Date: 26 May 2025
Available Online: 26 May 2025

Figures(6)

A visible-light induced cascade sulfonation/cyclization reaction of 3-allyl-2-arylquinazolinones employing water as an environmentally friendly solvent was revealed. This transition metal-free protocol, using 9-mesityl-10-methylacridinium perchlorate as the photocatalyst, represents a masterly tactic for the synthesis of sulfonated dihydroisoquinolino[1,2-b]quinazolinones featuring mild conditions, facile operation, and broad substrate scope.
- Environmentally friendly solvent,
- Sulfonation,
- Radical cascade cyclization,
- Visible-light,
- Quinazolinone
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