Citation: Junhua Li, Yu Fu, Yian Shi. A rapid access to fused polycyclic indolo[2,1-a]isoquinolins via Pd-catalyzed sequential Heck/C-H activation/amination reaction with diaziridinone[J]. Chinese Chemical Letters, ;2026, 37(3): 111376. doi: 10.1016/j.cclet.2025.111376 shu

A rapid access to fused polycyclic indolo[2,1-a]isoquinolins via Pd-catalyzed sequential Heck/C-H activation/amination reaction with diaziridinone

Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Institute of Natural and Synthetic Organic Chemistry, Changzhou University, Changzhou 213164, China

shiyian@cczu.edu.cn

Received Date: 22 January 2025
Revised Date: 20 May 2025
Accepted Date: 26 May 2025
Available Online: 27 May 2025

Figures(9)

Polycyclic pyrrole fused indolo[2,1-a]isoquinolins were efficiently generated from alkene-tethered indole derivatives and di–tert-butyldiaziridinone in up to 99% yield in the presence of Pd catalyst. The reaction likely proceeded via sequential Heck, CH activation, and amination process. Varying N-substituents of indole substrates led to indolo[3,2-b]indoles in up to 98% yields.
- Pd-catalyzed,
- Fused indolo[2,1-a]isoquinoline,
- Indolo[3,2-b]indole,
- Heck/C-H activation/amination,
- Diaziridinone
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沈阳化工大学材料科学与工程学院沈阳 110142