Citation: Shu-Qi Wu, Xinying Zhu, Fang-Yu Yuan, Han-Zhuang Weng, Lei Li, Dong Huang, Gui-Hua Tang, Sheng Yin. Malbrumpenoids A-N, unusually cyclized triterpenoids from the Euphorbia endophyte Malbranchea umbrina D16[J]. Chinese Chemical Letters, ;2026, 37(5): 111336. doi: 10.1016/j.cclet.2025.111336 shu

Malbrumpenoids A-N, unusually cyclized triterpenoids from the Euphorbia endophyte Malbranchea umbrina D16

Shu-Qi Wu ^{a, 1} ,
Xinying Zhu ^{a, 1} ,
Fang-Yu Yuan ^a ,
Han-Zhuang Weng ^{a, b} ,
Lei Li ^a ,
Dong Huang ^a ,
Gui-Hua Tang ^{a, *,} ,
Sheng Yin ^{a, *,}

a.
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
b.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology Visual Science, Guangzhou 510060, China

tanggh5@mail.sysu.edu.cn

yinsh2@mail.sysu.edu.cn

Received Date: 25 February 2025
Revised Date: 14 May 2025
Accepted Date: 16 May 2025
Available Online: 16 May 2025

Figures(6)

Molecular networking-guided chemical investigation of the Euphorbia endophyte Malbranchea umbrina D16 led to the isolation of 14 novel unusually cyclized triterpenoids (UCT) involving three different skeletal types. Compounds 1–10 are tricyclic triterpenoids featuring a 1-cyclohexyloctahydro-1H-indene core, in which 1 incoporates an unusual 7,7-dimethyl-6,8-dioxabicyclo[3.1.2]octane motif. Compounds 11–13 represent a rare class of bicyclic triterpenes (6/5 ring system) containing various O-heterocycles at the side chain. Compound 14 is an acyclic triterpenoid with O-heterocycles at both ends. Their structures were assigned by spectroscopic, chemical, computational, and crystallographic means, which also allowed the stereochemical revisions of three previously reported analogues. Compound 1 significantly inhibited the adipogenesis in 3T3-L1 adipocytes via activating the AMP-activated protein kinase (AMPK) signalling.
- Endophytes,
- Malbranchea umbrina D16,
- Unusually cyclized triterpenoids,
- Malbrumpenoid,
- Antiadipogenic activity,
- AMP-activated protein kinase
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