Citation: Menglin Zhang, Fanpeng Ran, Yun Zhang, Xiaoli Zhang, Zhigang Xu, Xiaoxiao Shi. Cyclodextrin-based nanotherapeutics: A promising strategy for enhanced cancer therapy[J]. Chinese Chemical Letters, ;2026, 37(1): 111232. doi: 10.1016/j.cclet.2025.111232 shu

Cyclodextrin-based nanotherapeutics: A promising strategy for enhanced cancer therapy

Menglin Zhang ^{a, 1} ,
Fanpeng Ran ^{b, 1} ,
Yun Zhang ^a ,
Xiaoli Zhang ^d ,
Zhigang Xu ^{a, c, *,} ,
Xiaoxiao Shi ^{a, *,}

a.
Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, School of Materials and Energy, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China
b.
School of Primary Education & Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing 401331, China
c.
Yibin Academy of Southwest University, Yibin 644000, China
d.
Pediatric Research Institute, Department of Hematology and Oncology, Shenzhen Children’s Hospital, Shenzhen 518038, China

zgxu@swu.edu.cn

xxshi7@swu.edu.cn

Received Date: 8 December 2024
Revised Date: 12 April 2025
Accepted Date: 16 April 2025
Available Online: 17 April 2025

Figures(10)

The development of highly effective therapeutics is a priority in addressing the escalating threat that cancer poses to human health. Cyclodextrins (CDs) with exceptional biocompatibility and devisable structural hierarchy are emerging as versatile building blocks for engineered drug delivery systems, showing a promising prospect in cancer therapy. CDs enable precise synthesis of functionalized polymers with tailored architectures, endowing their excellent stability and large surface area to prolong drug circulation, enhance solubility, and increase targeting efficiency. Recently, CD-based nanotherapeutics has shown transformative potential in chemotherapy, phototherapy, immunotherapy, gene therapy and other co-delivery systems of combination therapy. This review will introduce the types of CD-based nanotherapeutics, systematically summarize their design methods and anticancer application, and further discuss the prospects and challenges, providing a roadmap for advancing CD nanotechnology toward cancer therapeutics.
- CD-based nanotherapeutics,
- Polymers,
- Supramolecular nanoparticles,
- Drug delivery,
- Cancer therapy
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沈阳化工大学材料科学与工程学院沈阳 110142