Citation: Bo Xu, Mingjin Cui, Zhimin Luo, Lianhui Wang. Strain-driven intermetallic PtCo nanozymes for high and specific peroxidase-like activity[J]. Chinese Chemical Letters, ;2026, 37(8): 111227. doi: 10.1016/j.cclet.2025.111227 shu

Strain-driven intermetallic PtCo nanozymes for high and specific peroxidase-like activity

Bo Xu ^{a, 1} ,
Mingjin Cui ^{a, b, 1*,} ,
Zhimin Luo ^{a, *,} ,
Lianhui Wang ^{a, *,}

a.
State Key Laboratory of Organic Electronics and Information Displays (SKLOEID) & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), School of Chemistry and Life Sciences, College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications, Nanjing 210023, China
b.
Institute of Energy Materials Science (IEMS), University of Shanghai for Science and Technology, Shanghai 200093, China

mjcui@usst.edu.cn

iamzmluo@njupt.edu.cn

iamlhwang@njupt.edu.cn

Received Date: 17 March 2025
Revised Date: 9 April 2025
Accepted Date: 16 April 2025
Available Online: 17 April 2025

Figures(4)

Although the distinctive physicochemical properties of Pt-based intermetallic nanomaterials are well-recognized, the critical influence of Pt skin-induced lattice strain effects on their enzyme-mimicking catalytic performance remains unexplored. This knowledge gap primarily stems from the technical challenges in achieving atomic-level precision and structural uniformity when engineering active sites within Pt-based intermetallic systems. Herein, we demonstrate exceptional peroxidase-like catalytic activity (25.545 U/mg) and remarkable specificity through strain-engineered L1₀ PtCo@Pt core-shell architectures. Experimental and theoretical analyses reveal that significantly reduces H₂O₂ adsorption energy (-1.49 eV) and the energy barrier of rate-determining step (0.128 eV). This strain-driven electronic modulation enables a 17.4-fold enhancement in peroxidase-like activity compared to conventional Pt nanoparticles, establishing a quantitative correlation between interfacial lattice compression (3.5% strain) and catalytic efficiency. Three key advances emerge from this work: (1) Identification of lattice strain as a dominant descriptor for nanozyme specificity in H₂O₂ activation, (2) development of a universal synthesis framework (<1 min) for ordered intermetallic core-shell systems, and (3) demonstration of strain engineering as a generalizable strategy exceeding noble metal-dependent activity enhancement. The developed methodology not only resolves long-standing challenges in scalable nanozyme production but also opens new avenues for designing biocatalysts through atomic-level strain manipulation.
- Pt-based intermetallic,
- Nanozymes,
- Core-shell structure,
- Strain regulation,
- Enzyme-like catalysis
1. [1]
  D. Jiang, D. Ni, Z.T. Rosenkrans, et al., Chem. Soc. Rev. 48 (2019) 3683–3704. doi: 10.1039/c8cs00718g
2. [2]
  M. Liang, X. Yan, Acc. Chem. Res. 52 (2019) 2190–2200. doi: 10.1021/acs.accounts.9b00140
3. [3]
  Y. Lin, J. Ren, X. Qu, Acc. Chem. Res. 47 (2014) 1097–1105. doi: 10.1021/ar400250z
4. [4]
  H. Wei, E. Wang, Chem. Soc. Rev. 42 (2013) 6060–6093. doi: 10.1039/c3cs35486e
5. [5]
  J. Wu, X. Wang, Q. Wang, et al., Chem. Soc. Rev. 48 (2019) 1004–1076. doi: 10.1039/c8cs00457a
6. [6]
  M. Zandieh, J. Liu, Adv. Mater. 36 (2024) 2211041. doi: 10.1002/adma.202211041
7. [7]
  J. Feng, X. Yang, T. Du, et al., Adv. Sci. 10 (2023) 2303078. doi: 10.1002/advs.202303078
8. [8]
  G. Jiang, Q. Xu, J. Xie, et al., Adv. Funct. Mater. 34 (2024) 2405190. doi: 10.1002/adfm.202405190
9. [9]
  L. Li, L. Cao, X. Xiang, et al., Adv. Funct. Mater. 32 (2022) 2107530. doi: 10.1002/adfm.202107530
10. [10]
  W. Yang, X. Yang, L. Zhu, et al., Coord. Chem. Rev. 448 (2021) 214170. doi: 10.1016/j.ccr.2021.214170
11. [11]
  X. Zhang, S. Lin, S. Liu, et al., Coord. Chem. Rev. 429 (2021) 213652. doi: 10.1016/j.ccr.2020.213652
12. [12]
  J. Mujtaba, J. Liu, K.K. Dey, et al., Adv. Mater. 33 (2021) 2007465. doi: 10.1002/adma.202007465
13. [13]
  Z. Yang, J. Guo, L. Wang, et al., Small 20 (2024) 2307815. doi: 10.1002/smll.202307815
14. [14]
  J. Chen, X. Liu, G. Zheng, et al., Small 19 (2023) 2205924. doi: 10.1002/smll.202205924
15. [15]
  J. Chen, Q. Ma, M. Li, et al., Nat. Commun. 12 (2021) 3375. doi: 10.1038/s41467-021-23737-1
16. [16]
  J. Huang, L. Jiao, W. Xu, et al., ACS Appl. Mater. Interfaces 13 (2021) 33383–33391. doi: 10.1021/acsami.1c09100
17. [17]
  X. Liu, X. Liang, J. Yu, et al., Trends Anal. Chem. 169 (2023) 117386. doi: 10.1016/j.trac.2023.117386
18. [18]
  D. Wang, J. Wang, X.J. Gao, et al., Adv. Mater. 36 (2024) 2310033. doi: 10.1002/adma.202310033
19. [19]
  M. Feng, X. Li, X. Zhang, Y. Huang, Trends Anal. Chem. 166 (2023) 117220. doi: 10.1016/j.trac.2023.117220
20. [20]
  R. Fu, Z. Ma, H. Zhao, et al., Anal. Chem. 95 (2023) 10844–10858. doi: 10.1021/acs.analchem.3c01005
21. [21]
  F. Meng, P. Zhu, L. Yang, et al., Chem. Eng. J. 452 (2023) 139411. doi: 10.1016/j.cej.2022.139411
22. [22]
  H. Sun, Y. Zhou, J. Ren, X. Qu, Angew. Chem. Int. Ed. 57 (2018) 9224–9237. doi: 10.1002/anie.201712469
23. [23]
  J. Li, L. Luo, S. Wang, et al., PhotoMat 1 (2024) 1–14.
24. [24]
  H. Guo, S. Guo, CCS Chem. 7 (2024) 326–344.
25. [25]
  C. Liu, L. Gui, J.J. Zheng, et al., J. Am. Chem. Soc. 145 (2023) 19086–19097. doi: 10.1021/jacs.3c07048
26. [26]
  Z. Wang, R. Zhang, X. Yan, K. Fan, Mater. Today 41 (2020) 81–119. doi: 10.1016/j.mattod.2020.08.020
27. [27]
  J. Wu, Q. Liu, D. Jiao, et al., Angew. Chem. Int. Ed. 63 (2024) e202403203. doi: 10.1002/anie.202403203
28. [28]
  Z. Xi, X. Cheng, Z. Gao, et al., Nano Lett. 20 (2019) 272–277.
29. [29]
  J. Zhang, Y. Chen, M.G. Li, et al., Nano Lett. 24 (2024) 14373–14380. doi: 10.1021/acs.nanolett.4c04116
30. [30]
  Y. Ai, M.Q. He, H. Sun, et al., Adv. Mater. 35 (2023) 2302335. doi: 10.1002/adma.202302335
31. [31]
  Y. Nie, Z. Li, Y. Wang, et al., Appl. Catal. B 343 (2024) 123494. doi: 10.1016/j.apcatb.2023.123494
32. [32]
  Y. Tang, Y. Chen, Y. Wu, et al., Nano Lett. 23 (2022) 267–275.
33. [33]
  W. Xie, G. Zhang, Z. Guo, et al., Mater. Today Bio 16 (2022) 100411. doi: 10.1016/j.mtbio.2022.100411
34. [34]
  X. Yang, M. Tan, J. Guo, et al., Adv. Funct. Mater. 34 (2024) 2401963. doi: 10.1002/adfm.202401963
35. [35]
  L. Zhu, Z. Lai, J. Xu, et al., J. Mater. Chem. A 12 (2024) 28149–28160. doi: 10.1039/d4ta05081a
36. [36]
  W. Yang, L. Shang, X. Liu, et al., Chin. Chem. Lett. 35 (2024) 109501. doi: 10.1016/j.cclet.2024.109501
37. [37]
  M. Cui, C. Yang, S. Hwang, et al., Nano Lett. 22 (2022) 255–262. doi: 10.1021/acs.nanolett.1c03714
38. [38]
  Z. Huang, T. Li, B. Li, et al., J. Am. Chem. Soc. 146 (2024) 2167–2173. doi: 10.1021/jacs.3c12048
39. [39]
  B. Deng, L. Eddy, K.M. Wyss, et al., Nat. Rev. Clean Technol. 1 (2025) 32–54. doi: 10.1038/s44359-024-00002-4
40. [40]
  M. Winter, WebElements Periodic Table, University of Sheffield, 2025.
41. [41]
  X. Liu, J. Yang, J. Cheng, et al., Sens. Actuator. B 337 (2021) 129763. doi: 10.1016/j.snb.2021.129763
42. [42]
  Y. Xu, A. Huang, W. Yi, et al., Coord. Chem. Rev. 500 (2024) 215517. doi: 10.1016/j.ccr.2023.215517
43. [43]
  L. Yang, X. Xu, Y. Song, et al., Chem. Eng. J. 487 (2024) 150612. doi: 10.1016/j.cej.2024.150612
44. [44]
  X. Yu, Y. Wang, J. Zhang, et al., Adv. Healthcare Mater. 13 (2024) 2302023. doi: 10.1002/adhm.202302023
45. [45]
  H. Zhu, J. Deng, S. Mu, et al., Chem. Eng. J. 462 (2023) 142215. doi: 10.1016/j.cej.2023.142215
46. [46]
  L. Jiao, J. Wu, H. Zhong, et al., ACS Catal. 10 (2020) 6422–6429. doi: 10.1021/acscatal.0c01647
47. [47]
  C. Zhao, C. Xiong, X. Liu, et al., Chem. Commun. 55 (2019) 2285–2288. doi: 10.1039/c9cc00199a
48. [48]
  B. Jiang, D. Duan, L. Gao, et al., Nat. Protoc. 13 (2018) 1506–1520. doi: 10.1038/s41596-018-0001-1
49. [49]
  X. Shen, Z. Wang, X.J. Gao, X. Gao, Adv. Mater. 36 (2024) 2211151. doi: 10.1002/adma.202211151
50. [50]
  S. Zhong, Z. Zhang, Q. Zhao, et al., Nat. Commun. 15 (2024) 8097. doi: 10.1038/s41467-024-52277-7
51. [51]
  X. Yu, L. Wang, Z. Zhu, et al., Small 19 (2023) 2304818. doi: 10.1002/smll.202304818
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