Citation: Bo Xu, Mingjin Cui, Zhimin Luo, Lianhui Wang. Strain-driven intermetallic PtCo nanozymes for high and specific peroxidase-like activity[J]. Chinese Chemical Letters, ;2026, 37(8): 111227. doi: 10.1016/j.cclet.2025.111227 shu

Strain-driven intermetallic PtCo nanozymes for high and specific peroxidase-like activity

Bo Xu ^{a, 1} ,
Mingjin Cui ^{a, b, 1*,} ,
Zhimin Luo ^{a, *,} ,
Lianhui Wang ^{a, *,}

a.
State Key Laboratory of Organic Electronics and Information Displays (SKLOEID) & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), School of Chemistry and Life Sciences, College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications, Nanjing 210023, China
b.
Institute of Energy Materials Science (IEMS), University of Shanghai for Science and Technology, Shanghai 200093, China

mjcui@usst.edu.cn

iamzmluo@njupt.edu.cn

iamlhwang@njupt.edu.cn

Received Date: 17 March 2025
Revised Date: 9 April 2025
Accepted Date: 16 April 2025
Available Online: 17 April 2025

Figures(4)

Although the distinctive physicochemical properties of Pt-based intermetallic nanomaterials are well-recognized, the critical influence of Pt skin-induced lattice strain effects on their enzyme-mimicking catalytic performance remains unexplored. This knowledge gap primarily stems from the technical challenges in achieving atomic-level precision and structural uniformity when engineering active sites within Pt-based intermetallic systems. Herein, we demonstrate exceptional peroxidase-like catalytic activity (25.545 U/mg) and remarkable specificity through strain-engineered L1₀ PtCo@Pt core-shell architectures. Experimental and theoretical analyses reveal that significantly reduces H₂O₂ adsorption energy (-1.49 eV) and the energy barrier of rate-determining step (0.128 eV). This strain-driven electronic modulation enables a 17.4-fold enhancement in peroxidase-like activity compared to conventional Pt nanoparticles, establishing a quantitative correlation between interfacial lattice compression (3.5% strain) and catalytic efficiency. Three key advances emerge from this work: (1) Identification of lattice strain as a dominant descriptor for nanozyme specificity in H₂O₂ activation, (2) development of a universal synthesis framework (<1 min) for ordered intermetallic core-shell systems, and (3) demonstration of strain engineering as a generalizable strategy exceeding noble metal-dependent activity enhancement. The developed methodology not only resolves long-standing challenges in scalable nanozyme production but also opens new avenues for designing biocatalysts through atomic-level strain manipulation.
- Pt-based intermetallic,
- Nanozymes,
- Core-shell structure,
- Strain regulation,
- Enzyme-like catalysis
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