Citation: Sida Huang, Shihai Yin, Aparna Kushwaha, Abhinav Kumar, Yu Deng, Yanqiong Peng, Ying Pan, Jianqiang Liu, Yong Huang. MOFs-based nanomaterials for bone repair and regeneration: Current status and future perspectives[J]. Chinese Chemical Letters, ;2026, 37(8): 111211. doi: 10.1016/j.cclet.2025.111211 shu

MOFs-based nanomaterials for bone repair and regeneration: Current status and future perspectives

Sida Huang ^{a, 1} ,
Shihai Yin ^{b, 1} ,
Aparna Kushwaha ^{c, 1} ,
Abhinav Kumar ^{c, *,} ,
Yu Deng ^a ,
Yanqiong Peng ^a ,
Ying Pan ^{a, *,} ,
Jianqiang Liu ^a ,
Yong Huang ^{a, *,}

a.
Dongguan Key Laboratory of Drug Design and Formulation Technology, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China
b.
Hand Surgery Department, Liaobu Hospital of Guangdong Medical University, Dongguan 523000, China
c.
Department of Chemistry, Faculty of Science, University of Lucknow, Lucknow 226007, India

abhinavmarshal@gmail.com

panying@gdmu.edu.cn

yonghuang@gdmu.edu.cn

Received Date: 13 January 2025
Revised Date: 8 April 2025
Accepted Date: 15 April 2025
Available Online: 17 April 2025

Figures(15)

Bone abnormalities induced due to inflammation, trauma, or diabetes have emerged as a serious issue during treatment and post-treatment. Currently, the prevalent treatments for bone abnormalities are surgery and antibiotics. However, they are progressively struggling to meet clinical needs. Metal-organic frameworks (MOFs) are acquiring attention among many bone repair and bone regeneration materials due to their excellent role in this area of research. MOFs -based nanomaterials are characterized by long-term stability, large specific surface area, and can be easily modifiable. Furthermore, their porous structure and increased mechanical capabilities are similar to alternative tissues, making them useful for bone repair and regeneration. This review article outlines the application of MOFs in bone repair and bone regeneration therapy. First, the mechanics of bone repair and regeneration are discussed, followed by a summary of the most frequent synthetic methods of MOFs for treating bone defects. Secondly, the strategies of different types of MOFs in bone repair and bone regeneration therapies are reviewed. Eventually, the challenges and future of MOFs in bone repairs and bone regeneration therapies are described, introducing a novel approach to treating bone abnormalities.
- MOFs,
- Bone repair,
- Bone regeneration therapy,
- Drug delivery,
- Nanomaterials
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沈阳化工大学材料科学与工程学院沈阳 110142