Citation: Jing Zhao, Tian Huang, Dongyang Zhang, Jianliang Shen, Jintao Wang. NIR-enhanced oxidase-like activity of manganese dioxide nanoparticles for combating subcutaneous methicillin-resistant Staphylococcus aureus infections[J]. Chinese Chemical Letters, ;2026, 37(4): 111199. doi: 10.1016/j.cclet.2025.111199 shu

NIR-enhanced oxidase-like activity of manganese dioxide nanoparticles for combating subcutaneous methicillin-resistant Staphylococcus aureus infections

Jing Zhao ^a ,
Tian Huang ^a ,
Dongyang Zhang ^d ,
Jianliang Shen ^{b, c, *,} ,
Jintao Wang ^{a, *,}

a.
School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China
b.
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
c.
Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China
d.
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, the Fifth Affiliated Hospital and School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China

shenjl@wiucas.ac.cn

jintaochem@163.com

Received Date: 23 December 2024
Revised Date: 8 April 2025
Accepted Date: 10 April 2025
Available Online: 12 April 2025

Figures(4)

The inappropriate use of antibiotics has led to the emergence of drug-resistant bacteria and the formation of persistent biofilms, rendering conventional antibiotics ineffective against these infections. To address this challenge, the enzyme-like activity of nanozymes, particularly those with photothermal effects, is being explored. However, the development of nanozymes is hindered by the complex synthesis processes involved and the consumption of reactive oxygen species (ROS) by reducing products in bacteria. This article presents an interesting strategy utilizing near-infrared laser-enhanced oxidase-like (OXD-like) activity of manganese dioxide nanoparticles (MnO₂ NPs) to combat subcutaneous infections caused by methicillin-resistant Staphylococcus aureus (MRSA). MnO₂ NPs, characterized by flower-like morphology and broad near-infrared absorption, exhibited favorable OXD-like activity and a stable photothermal effect. Experiments in vitro revealed that the combined high thermal effect and the substantial production of ROS effectively targeted MRSA and disrupted biofilm. The efficacy of MnO₂ in vivo was validated through the establishment of a subcutaneous abscess model. Additionally, a series of biosafety tests, including routine blood tests and blood biochemistry analyses, confirmed the safety of MnO₂ in vivo. Collectively, these findings suggest that combination therapy involving MnO₂ presents a promising therapeutic approach for addressing infections associated with biofilms and drug-resistant bacteria.
- Manganese oxide,
- Photothermal therapy,
- Oxidase-like activity,
- Anti-biofilm therapy,
- Anti-infection therapy
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