Citation: Juan Tao, Jinlong Yang, Mengyu Zhao, Quangang Zhu, Zhongjian Chen, Jianping Qi. Emerging trends in permeation-enhancing technologies for oral peptide delivery[J]. Chinese Chemical Letters, ;2026, 37(3): 111170. doi: 10.1016/j.cclet.2025.111170 shu

Emerging trends in permeation-enhancing technologies for oral peptide delivery

Juan Tao ^{a, b, 1} ,
Jinlong Yang ^{c, 1} ,
Mengyu Zhao ^a ,
Quangang Zhu ^c ,
Zhongjian Chen ^{c, *,} ,
Jianping Qi ^{a, c, *,}

a.
School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China
b.
School of Chinese Medicine, Jiangsu College of Nursing, Huaian 223001, China
c.
Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China

aajian818@163.com

qijianping@fudan.edu.cn

Received Date: 16 December 2024
Revised Date: 27 March 2025
Accepted Date: 1 April 2025
Available Online: 1 April 2025

Figures(4)

Peptides are increasingly favored as therapeutic agents due to their high efficacy, selectivity, and minimal side effects. However, they often face challenges related to poor stability and limited permeability through the gastrointestinal tract (GIT) and epithelia, necessitating parenteral administration. Despite this, there is a considerable demand for oral administration in clinical practice. To address the urgent clinical need for oral delivery, researchers have developed various technologies to surmount these challenges, including device-related systems, permeation enhancers (PEs), nanocarrier-based systems, and more. This review systematically explores the physiological barriers impacting peptide permeability and discusses the permeation-enhancing technologies designed to overcome them. It also reviews the oral peptide delivery systems currently available or under clinical investigation, offering insights into future developments in this field.
- Oral peptides,
- Permeation-enhancing technologies,
- Targeted delivery,
- Physiological barriers,
- Nanocarriers
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