Citation: Yuwei Liang, Jianwei Huang, Zhiqiang Zhang, Qinghong Yang, Aiwen Lei, Hong Yi. Electrochemical Mn-catalyzed nitrogenation of alkynes to nitriles via C≡C bonds cleavage[J]. Chinese Chemical Letters, ;2026, 37(4): 111166. doi: 10.1016/j.cclet.2025.111166 shu

Electrochemical Mn-catalyzed nitrogenation of alkynes to nitriles via C≡C bonds cleavage

Yuwei Liang ^a ,
Jianwei Huang ^b ,
Zhiqiang Zhang ^a ,
Qinghong Yang ^a ,
Aiwen Lei ^{a, *,} ,
Hong Yi ^{a, *,}

a.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
b.
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, China

aiwenlei@whu.edu.cn

hong.yi@whu.edu.cn

Received Date: 24 September 2024
Revised Date: 17 March 2025
Accepted Date: 1 April 2025
Available Online: 1 April 2025

Figures(5)

As fundamental chemicals, alkynes have been pivotal in synthesizing numerous value-added compounds. Direct manipulation of alkynes offers rapid access to diverse chemical spaces. Cleaving the alkyne triple bond has traditionally required harsh conditions due to its high bond dissociation energy. Here, we present a manganese-catalyzed electrochemical nitrogenation method for the direct cleavage of C≡C bonds, efficiently generating various nitriles under mild conditions. This reaction demonstrates extensive functional group tolerance and eliminates the need for stoichiometric chemical oxidants. CV experiments verified the role of Mn catalysis, and the N₃ radical intermediate was confirmed by EPR spectroscopy. Our synthetic protocol provides a promising and versatile alternative for constructing nitrogen-containing compounds, potentially transforming approaches in chemical synthesis
- Electrochemistry,
- Manganese catalyst,
- Nitrogenation,
- Cleavage of alkynes
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