Citation: Ruohao Zhang, Yifei Zhou, Yu Lu, Xudong Sun, Jitong Gong, Kehong Lv, Xinyu Fu, Yukai Cheng, Jing Feng, Hongjie Zhang. Au-reinforced chemo-photodynamic therapy of lanthanide-doped nanoplatforms with upconversion-downshifting luminescence via catalytic amplification[J]. Chinese Chemical Letters, ;2026, 37(4): 111144. doi: 10.1016/j.cclet.2025.111144 shu

Au-reinforced chemo-photodynamic therapy of lanthanide-doped nanoplatforms with upconversion-downshifting luminescence via catalytic amplification

Ruohao Zhang ^{a, b} ,
Yifei Zhou ^{a, b} ,
Yu Lu ^{a, d} ,
Xudong Sun ^{b, c} ,
Jitong Gong ^{a, b} ,
Kehong Lv ^{a, b} ,
Xinyu Fu ^{a, b} ,
Yukai Cheng ^{a, b} ,
Jing Feng ^{a, b, *,} ,
Hongjie Zhang ^{a, b, e, *,}

a.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
c.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
d.
College of Chemistry, Jilin University, Changchun 130012, China
e.
Department of Chemistry, Tsinghua University, Beijing 100084, China

fengj@ciac.ac.cn

hongjie@ciac.ac.cn

hjzhang2019@tsinghua.edu.cn

Received Date: 30 December 2024
Revised Date: 24 March 2025
Accepted Date: 26 March 2025
Available Online: 26 March 2025

Figures(7)

The vast majority of lanthanide-doped nanoparticles (LnNPs) exhibit a single mode of upconversion luminescence (UCL) or downshifting luminescence (DSL) for photodynamic therapy (PDT) or diagnostic imaging of tumors, respectively. In order to achieve both UCL and DSL, it is often necessary to dope the luminescent ions in different shell layers to prevent their luminescence quenching, resulting in tedious synthesis steps. Herein, upconversion-downshifting nanoparticles (UDNPs) co-doped with Er³⁺ and Ho³⁺ enable the simultaneous dual-wavelength DSL for in vivo near-infrared (NIR)-Ⅱ fluorescence imaging of tumors. On the other hand, the UCL of UDNPs could activate merocyanine photosensitizers (MC 540), resulting in the generation of reactive oxygen species (ROS) and the achievement of PDT. Importantly, Au NPs with glucose oxidase-like properties could consume glucose and promote H₂O₂ accumulation in tumor cells. Au-catalyzed UDNPs modified with Fe-tannic acid (FeTA) (UDNP-MC/Au-FeTA) could not only enhance the effect of PDT but also realize chemodynamic therapy (CDT) by reacting with Fe²⁺ generated from slightly acidic decomposition of FeTA to accelerate hydroxyl radical (^•OH) generation. The combination of long- and short-acting dual-dynamic therapy could mutually reinforce and compensate for the lack of therapeutic efficacy resulting from luminescence quenching caused by co-doping luminescent ions. Therefore, UDNP-MC/Au-FeTA guided by NIR-Ⅱ fluorescence imaging could achieve efficient synergistic dual-dynamic therapy of tumors through differentially expressed genes associated with apoptosis and oxidative stress-related pathways. NIR-Ⅱ fluorescence imaging diagnostic and dual-dynamic therapeutic strategy, which employs Au-catalyzed lanthanide co-doped UDNPs represents a dexterous design concept for promising anti-tumor applications.
- Upconversion luminescence,
- Downshifting luminescence,
- Au nanoparticles,
- NIR-Ⅱ fluorescence imaging,
- Chemo-photodynamic therapy
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