Citation: Xiaodan Liang, Tong Tong, Caihong Xian, Jiyuan Du, Biying Tan, Liying Wang, Jingyi Hou, Jun Wu. Metal-based biomaterials for treating bone diseases[J]. Chinese Chemical Letters, ;2026, 37(4): 111140. doi: 10.1016/j.cclet.2025.111140 shu

Metal-based biomaterials for treating bone diseases

Xiaodan Liang ^{a, b, 1} ,
Tong Tong ^{b, d, 1} ,
Caihong Xian ^{b, d, 1} ,
Jiyuan Du ^b ,
Biying Tan ^a ,
Liying Wang ^{b, *,} ,
Jingyi Hou ^{e, *,} ,
Jun Wu ^{a, b, c, *,}

a.
Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China
b.
Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Nansha, Guangzhou 511400, China
c.
Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong 999077, China
d.
Department of Hematology, Department of Orthopedics, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China
e.
Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

wangly53@mail2.sysu.edu.cn

houjy7@mail.sysu.edu.cn

junwuhkust@ust.hk

Received Date: 12 January 2025
Revised Date: 24 March 2025
Accepted Date: 25 March 2025
Available Online: 25 March 2025

Figures(5)

Bone-related diseases resulting from accidents, illnesses, and injuries have become increasingly common in recent years. Treating these conditions poses significant challenges, including prolonged recovery times, high costs, and unpredictable outcomes, which can lead to complications such as infections and reduced muscle strength. Although autologous bone transplantation is regarded as the "gold standard" for addressing bone diseases, its application is often limited by complications at the donor site and the risk of infection. This underscores the urgent need to explore alternatives to autogenous bone transplantation. In response, a range of biomaterials for bone repair have been developed, with metal-based biomaterials emerging as effective adjuncts that enhance and optimize the repair and regeneration of bone tissue. These materials can actively influence the bone repair process through mechanisms such as inductive osteogenesis, immunomodulation, and pro-angiogenesis. This review begins by highlighting the biological effects of metal-based biomaterials, followed by a comprehensive overview of their macro- and micro-scale classifications and applications for treating various bone diseases. Finally, the review addresses future directions and challenges associated with the use of metal-based biomaterials in bone repair, aiming to propose promising strategies for the treatment of bone-related diseases.
- Metal-based biomaterials,
- Bone diseases,
- Macro- and microscale,
- Biological effects,
- Treating bone diseases
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沈阳化工大学材料科学与工程学院沈阳 110142