Citation: Ting Zhang, Deqiang Chen, Ningzhi Zhang, Mingxu Zhang, Qiang Huang, Wei Liu, Ran Gao, Yong Zhang. Self-assembled supramolecular nanofibers integrate pH-responsive drug delivery and antimicrobial for combined cancer therapy[J]. Chinese Chemical Letters, ;2026, 37(2): 111117. doi: 10.1016/j.cclet.2025.111117 shu

Self-assembled supramolecular nanofibers integrate pH-responsive drug delivery and antimicrobial for combined cancer therapy

Ting Zhang ^{a, e, 1,*,} ,
Deqiang Chen ^{e, 1} ,
Ningzhi Zhang ^e ,
Mingxu Zhang ^e ,
Qiang Huang ^{a, e} ,
Wei Liu ^{a, e} ,
Ran Gao ^e ,
Yong Zhang ^{a, b, c, d, *,}

a.
State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150081, China
b.
Department of Cardiology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China
c.
State Key Laboratory-Province Key Laboratories of Biomedicine-Pharmaceutics of China, and Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin Medical University, Harbin 150081, China
d.
Research Unit of Noninfectious Chronic Diseases in Frigid Zone (2019RU070), Chinese Academy of Medical Sciences, Harbin 150081, China
e.
Department of Inorganic Chemistry and Physical Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, China

tingzhang@hrbmu.edu.cn

hmuzhangyong@hotmail.com

Received Date: 10 January 2025
Revised Date: 18 March 2025
Accepted Date: 19 March 2025
Available Online: 20 March 2025

Figures(5)

Constructing nanofibers with specific therapeutic effects against cancer is a challenge. Here, we present the synthesis approach and application prospects of supramolecular nanofibers, which are based on cucurbit[8]uril (CB[8]) as the host and terpyridine lanthanum ions metal complex as the guest, constructed by layer-by-layer self-assembly through supramolecular interaction. Moreover, nanofibers with lanthanide luminescence properties exhibit surprising pH-responsive deformation properties and antibacterial behavior. In the tumor micro-environment, the dramatic reduction in the size of the nanofibers enables specific and hierarchical release of anticancer drugs in tumor cells to exert an advanced therapeutic effect. In addition, the synergistic therapeutic efficacy was achieved by reducing the excess of Gram-positive and Gram-negative bacteria surrounding tumor cells. The novel supramolecular nanofibers with sequential drug release and combined therapeutic mode provide new guidance for the synthesis of drug carrier materials and direction for the promotion of nanomaterial-mediated cancer therapy.
- pH-responsive self-assembly nanofibers,
- Supramolecular interaction,
- Sequential release,
- Antibacterial,
- Combination therapy
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