Citation: Yiyang Zhang, Guangshu Yuan, Xiangkun Meng, Xu Zhang, Lei Yu. Promoting the catalytic activities of polyanilines for L-lactic acid condensation by calcium-doping: A biocompatible strategy[J]. Chinese Chemical Letters, ;2025, 36(12): 111069. doi: 10.1016/j.cclet.2025.111069 shu

Promoting the catalytic activities of polyanilines for L-lactic acid condensation by calcium-doping: A biocompatible strategy

Yiyang Zhang ^{a, b, *,} ,
Guangshu Yuan ^b ,
Xiangkun Meng ^b ,
Xu Zhang ^b ,
Lei Yu ^{a, b, *,}

a.
School of Mechanical Engineering, Yangzhou University, Yangzhou 225127, China
b.
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China

008011@yzu.edu.cn

yulei@yzu.edu.cn

Received Date: 25 December 2024
Revised Date: 9 March 2025
Accepted Date: 11 March 2025
Available Online: 13 March 2025

Figures(7)

Polyanilines (PANIs) are easily accessible materials that can be employed to prepare catalysts for a variety of useful reactions. Investigations in the field are of profound academic and industrial values. In this work, we unexpectedly found that, calcium-doping could enhance the specific surface area and pore volume of poly-p-anisidine (PANI-OMe), so that the catalytic activity of the material could be significantly improved. It is notable that Ca-doping significantly enhanced the pore size of the material to 291.5 nm, making it a macroporous material that can allow even more sufficient contact of the catalytically active sites of nitrogen to contact with the macromolecules such as the PLA oligomer. Thus, the Ca-doped PANI-OMe (PANI-OMe/Ca) could well catalyse the condensation reaction of L-lactic acid to synthesize L-lactide in 75.0% yield with 98.2% optical purity at kilogram reaction scale. Since Ca is a biocompatible element that widely exists in both human and animal bodies, the Ca-doping protocol provides a biocompatible catalyst for L-lactide production. This is an important progress because L-lactide is widely employed as the basic raw material to produce the environment-friendly bio-degradable materials and the biomedical polymers. It may also inspire new strategies for designing the catalyst for the reactions involving macromolecular intermediates.
- Calcium,
- Polyaniline,
- L-Lactic acid,
- Lactide,
- Biocompatible materials,
- Polymer
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