Citation: Donghu Yu, Junneng Wang, Lei Hu, Youxian Wu, Tianqing Wang, Zhiyu Li, Zefen Wang, Qihang Ding, Yao Sun, Zhiqiang Li. Knowledge structures and research hotspots of immunotherapy for brain metastasis, glioma, meningioma, and pituitary adenoma: A bibliometric and visualization review[J]. Chinese Chemical Letters, ;2025, 36(12): 110995. doi: 10.1016/j.cclet.2025.110995 shu

Knowledge structures and research hotspots of immunotherapy for brain metastasis, glioma, meningioma, and pituitary adenoma: A bibliometric and visualization review

Donghu Yu ^{a, 1} ,
Junneng Wang ^{a, 1} ,
Lei Hu ^{a, 1} ,
Youxian Wu ^a ,
Tianqing Wang ^a ,
Zhiyu Li ^a ,
Zefen Wang ^{b, *,} ,
Qihang Ding ^{c, *,} ,
Yao Sun ^{d, *,} ,
Zhiqiang Li ^{a, *,}

a.
Brain Glioma Center & Department of Neurosurgery, International Science and Technology Cooperation Base for Research and Clinical Techniques for Brain Glioma Diagnosis and Treatment, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
b.
Department of Physiology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China
c.
Department of Chemistry, Korea University, Seoul 02841, South Korea
d.
National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China

wangzf@whu.edu.cn

dingqihang@whu.edu.cn

sunyaogbasp@mail.ccnu.edu.cn

lizhiqiang@whu.edu.cn

Received Date: 4 November 2024
Revised Date: 19 February 2025
Accepted Date: 21 February 2025
Available Online: 21 February 2025

Figures(4)

Recent insights into the immune landscape of the brain tumor microenvironment shed new light on immunotherapy for various brain tumors. This study provides comprehensive overviews of the development trends of immunotherapy for four common brain tumors (brain metastasis, glioma, meningioma, and pituitary adenoma), for which immunotherapy-related clinical trials have been conducted. Publications spanning from January 1, 2011, to December 31, 2023, were retrieved from the Web of Science Core Collection for a bibliometric analysis aimed at visualizing research trends and hotspots in immunotherapy for brain metastases, gliomas, meningiomas, and pituitary adenomas. Additionally, ongoing clinical trials were reviewed to identify the frontiers of immunotherapy in brain tumors. Research activity has significantly increased for brain metastasis and glioma, while studies on meningioma and pituitary adenoma remain in the nascent stages. The United States and China are the leading countries in these four research areas. Keyword analysis and ongoing trials underscore the crucial role of immune checkpoint inhibitors, which are currently a focal point in the treatment of various brain tumors. This review outlines the knowledge structures and research priorities in immunotherapy over the past 13 years, providing valuable insights for researchers in these fields.
- Immunotherapy,
- Brain tumors,
- Bibliometric analysis,
- Clinical trials,
- Immune checkpoint inhibitors
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沈阳化工大学材料科学与工程学院沈阳 110142