Citation: Yuanyi Zhou, Lili Wang, Li Chen, Qingbing Zha, Yu Meng, Mingshan Zhu. Functional inorganic nanomaterials for renal cell carcinoma treatment: Advancements and trends[J]. Chinese Chemical Letters, ;2025, 36(12): 110994. doi: 10.1016/j.cclet.2025.110994 shu

Functional inorganic nanomaterials for renal cell carcinoma treatment: Advancements and trends

Yuanyi Zhou ^{a, c} ,
Lili Wang ^{b, *,} ,
Li Chen ^b ,
Qingbing Zha ^a ,
Yu Meng ^{a, *,} ,
Mingshan Zhu ^{c, *,}

a.
Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People’s Hospital), Heyuan 517465, China
b.
Department of General Practice, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
c.
College of Environment and Climate, Jinan University, Guangzhou 511443, China

lili_w301@163.com

mengy@jnu.edu.cn

zhumingshan@jnu.edu.cn

Received Date: 10 January 2025
Revised Date: 17 February 2025
Accepted Date: 20 February 2025
Available Online: 21 February 2025

Figures(7)

Renal cell carcinoma (RCC) as one of the most commonly diagnosed cancers threatens human health. The treatment of RCC demands more advanced protocols for better prognosis and higher quality of life. In recent years, the blooming of nanomaterials in various fields demonstrates its critical role as one of the most important components in constructing a smart therapeutic platform against RCC. Herein, focusing on the therapeutic inorganic nanomaterials (such as carbon nanomaterials, metal nanomaterials, oxide nanomaterials), their functions as drug carriers, external field sensitizers, and/or RCC microenvironment sensitizers are analyzed. In combination with the advantages of nanomaterial and RCC characteristics, the trends in integrating nanomaterial to construct multifunctional theranostic platforms for RCC treatment are highlighted. Also, possible solutions concerning the life trajectory and long-term toxicity of nanomaterials are put forward. These perspectives may promote the development of smarter and more effective systems for comprehensive RCC treatment.
- Inorganic nanomaterials,
- Environment responsiveness,
- Renal cell carcinoma,
- Material design,
- Toxicity
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