Citation: Yuanyi Zhou, Lili Wang, Li Chen, Qingbing Zha, Yu Meng, Mingshan Zhu. Functional inorganic nanomaterials for renal cell carcinoma treatment: Advancements and trends[J]. Chinese Chemical Letters, ;2025, 36(12): 110994. doi: 10.1016/j.cclet.2025.110994 shu

Functional inorganic nanomaterials for renal cell carcinoma treatment: Advancements and trends

Yuanyi Zhou ^{a, c} ,
Lili Wang ^{b, *,} ,
Li Chen ^b ,
Qingbing Zha ^a ,
Yu Meng ^{a, *,} ,
Mingshan Zhu ^{c, *,}

a.
Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People’s Hospital), Heyuan 517465, China
b.
Department of General Practice, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
c.
College of Environment and Climate, Jinan University, Guangzhou 511443, China

lili_w301@163.com

mengy@jnu.edu.cn

zhumingshan@jnu.edu.cn

Received Date: 10 January 2025
Revised Date: 17 February 2025
Accepted Date: 20 February 2025
Available Online: 21 February 2025

Figures(7)

Renal cell carcinoma (RCC) as one of the most commonly diagnosed cancers threatens human health. The treatment of RCC demands more advanced protocols for better prognosis and higher quality of life. In recent years, the blooming of nanomaterials in various fields demonstrates its critical role as one of the most important components in constructing a smart therapeutic platform against RCC. Herein, focusing on the therapeutic inorganic nanomaterials (such as carbon nanomaterials, metal nanomaterials, oxide nanomaterials), their functions as drug carriers, external field sensitizers, and/or RCC microenvironment sensitizers are analyzed. In combination with the advantages of nanomaterial and RCC characteristics, the trends in integrating nanomaterial to construct multifunctional theranostic platforms for RCC treatment are highlighted. Also, possible solutions concerning the life trajectory and long-term toxicity of nanomaterials are put forward. These perspectives may promote the development of smarter and more effective systems for comprehensive RCC treatment.
- Inorganic nanomaterials,
- Environment responsiveness,
- Renal cell carcinoma,
- Material design,
- Toxicity
1. [1]
  R.M. Carey, H.M. Siragy, Trends Endocrin. Met. 14 (2003) 274–281.
2. [2]
  F. Bray, M. Laversanne, H. Sung, et al., CA-Cancer J. Clin. 74 (2024) 229–263. doi: 10.3322/caac.21834
3. [3]
  X. Wang, L. Yang, Z. Chen, et al., CA-Cancer J. Clin. 58 (2008) 97–110. doi: 10.3322/CA.2007.0003
4. [4]
  J.S. Lam, O. Shvarts, J.T. Leppert, et al., J. Urol. 174 (2005) 466–472. doi: 10.1097/01.ju.0000165572.38887.da
5. [5]
  K. Gupta, J.D. Miller, J.Z. Li, et al., Cancer Treat. Rev. 34 (2008) 193–205.
6. [6]
  T. Powles, E.R. Plimack, D. Soulières, et al., Lancet Oncol. 21 (2020) 1563–1573.
7. [7]
  J. Bedke, L. Albiges, U. Capitanio, et al., Eur. Urol. 81 (2022) 134–137.
8. [8]
  Y. Huang, J. Wang, K. Jiang, et al., J. Control. Release 334 (2021) 127–137.
9. [9]
  H. Pavenstädt, W. Kriz, M. Kretzler, Physiol. Rev. 83 (2003) 253–307. doi: 10.1152/physrev.00020.2002
10. [10]
  C.P. Liu, Y. Hu, J.C. Lin, et al., Med. Res. Rev. 39 (2019) 561–578. doi: 10.1002/med.21532
11. [11]
  R.M. Williams, J. Shah, H.S. Tian, et al., Hypertension 71 (2018) 87–94.
12. [12]
  W. Song, S.N. Musetti, L. Huang, Biomaterials 148 (2017) 16–30.
13. [13]
  Y. Liu, X. Wang, M. Hussain, et al., Med. Sci. 6 (2018) 100.
14. [14]
  N. Ahmed, H. Fessi, A. Elaissari, Drug Discov. Today 17 (2012) 928–934.
15. [15]
  S.S. Das, P. Bharadwaj, M. Bilal, et al., Polymers 12 (2020) 1397. doi: 10.3390/polym12061397
16. [16]
  M.H. He, L. Chen, T. Zheng, et al., Front. Pharmacol. 9 (2018) 745.
17. [17]
  J. Li, K. Wu, J. Zhang, et al., Biomed. Pharmacother. 167 (2023) 115444.
18. [18]
  Z. Qian, Y. Zhang, J. Yuan, et al., Front. Bioeng. Biotech. 11 (2023) 1111977.
19. [19]
  R. Wu, K. Wang, Y. Gai, et al., J. Nanobiotechnol. 21 (2023) 3.
20. [20]
  D. Maiti, X. Tong, X. Mou, et al., Front. Pharmacol. 9 (2019) 1401.
21. [21]
  P.K. Jiwanti, B.Y. Wardhana, L.G. Sutanto, et al., Molecules 27 (2022) 7578. doi: 10.3390/molecules27217578
22. [22]
  M. Shin, J. Lim, Y. Park, et al., RSC Adv. 14 (2024) 7142–7156. doi: 10.1039/d3ra08946k
23. [23]
  B. Han, Y.L. Zhang, Q.D. Chen, et al., Adv. Funct. Mater. 28 (2018) 1802235.
24. [24]
  S.V. Torti, F. Byrne, O. Whelan, et al., Int. J. Nanomed. 2 (2007) 707–714.
25. [25]
  A. Burke, X. Ding, R. Singh, et al., Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 12897–12902. doi: 10.1073/pnas.0905195106
26. [26]
  J. Li, J. Wang, D. Sun, et al., J. Biomed. Nanotechnol. 12 (2016) 1604–1616. doi: 10.1166/jbn.2016.2271
27. [27]
  Z. Jiang, H. Jin, S. Sun, et al., Mat. Sci. Eng. C: Mater. 93 (2018) 846–852.
28. [28]
  R. Jia, T. Li, W. Jiang, et al., Mater. Design 224 (2022) 111287.
29. [29]
  Y. Zhou, K. Ma, J. Liu, et al., Chin. Chem. Lett. 35 (2024) 109056.
30. [30]
  L. Wang, P. Yin, Z. Jing, et al., Surf. Interfaces 46 (2024) 104147.
31. [31]
  J.J. Xu, W.C. Zhang, Y.W. Guo, et al., Drug Deliv. 29 (2022) 664–678.
32. [32]
  R. Khursheed, K. Dua, S. Vishwas, et al., Biomed. Pharmacother. 150 (2022) 112951.
33. [33]
  R.N. Pedro, T. Thekke-Adiyat, R. Goel, et al., Urology 76 (2010) 494–498.
34. [34]
  S. Nikzad, G. Mahmoudi, P. Amini, et al., J. Renal Inj. Prev. 6 (2016) 103–108. doi: 10.15171/jrip.2017.20
35. [35]
  C. Callaghan, D. Peralta, J. Liu, et al., J. Pharm. Sci. 105 (2016) 284–292.
36. [36]
  J. Liu, C. Abshire, C. Carry, et al., BJU Int. 119 (2017) 342–348. doi: 10.1111/bju.13590
37. [37]
  R. Liu, Q. Pei, T. Shou, et al., Int. J. Nanomed. 14 (2019) 4091–4103. doi: 10.2147/ijn.s203222
38. [38]
  E.J. Nam, S.K. Kong, I. Cho, et al., J. Drug Deliv. Sci. Tec. 91 (2024) 105179.
39. [39]
  P. Zhao, X. Chen, Q. Wang, et al., Nanomedicine 15 (2020) 1079–1096. doi: 10.2217/nnm-2019-0417
40. [40]
  S.A. Read, S. Obeid, C. Ahlenstiel, et al., Adv. Nutr. 10 (2019) 696–710. doi: 10.1093/advances/nmz013
41. [41]
  S. Hameed, J. Iqbal, M. Ali, et al., Mater. Res. Express 6 (2019) 102005. doi: 10.1088/2053-1591/ab40df
42. [42]
  S. El-Sonbaty, E.I. Kandil, R.A.H. Haroun, Biol. Trace Elem. Res. 201 (2023) 272–281. doi: 10.1007/s12011-022-03126-5
43. [43]
  J. Chen, F. Ren, W. Cao, et al., Nanomedicine: NBM 34 (2021) 102370.
44. [44]
  C. Li, P. Zhu, H. Xiang, et al., Mater. Today Bio. 18 (2023) 100513.
45. [45]
  J. Cheng, W. Wan, W. Zhu, Chin. J. Chem. 34 (2016) 53–58. doi: 10.1002/cjoc.201500339
46. [46]
  C. Yang, Y. Zhu, D. Li, et al., Small 17 (2021) e2101837.
47. [47]
  M.P. Vinardell, M. Mitjans, Nanomaterials 5 (2015) 1004–1021. doi: 10.3390/nano5021004
48. [48]
  X. Wang, D. Li, Z. Xia, et al., Arab. J. Chem. 15 (2022) 103753. doi: 10.1016/j.arabjc.2022.103753
49. [49]
  X. Zhou, T. Cao, J. Oncol. 2022 (2022) 2883404.
50. [50]
  A. Grillone, E.R. Riva, A. Mondini, et al., Adv. Healthc. Mater. 4 (2015) 1681–1690. doi: 10.1002/adhm.201500235
51. [51]
  M.V. Yigit, A. Moore, Z. Medarova, Pharm. Res. 29 (2012) 1180–1188. doi: 10.1007/s11095-012-0679-7
52. [52]
  A. Takke, P. Shende, Life Sci. 275 (2021) 119377.
53. [53]
  A. Takke, P. Shende, Colloid Surface A 628 (2021) 127349.
54. [54]
  T.V.M. Sreekanth, M. Pandurangan, G.R. Dillip, et al., J. Photoch. Photobio. B 164 (2016) 174–181.
55. [55]
  Q. Yang, Y. Wang, Q. Yang, et al., Biomaterials 146 (2017) 72–85.
56. [56]
  M. Shi, S. Wang, S. Zheng, et al., Colloid Surface B 185 (2020) 110625.
57. [57]
  L. Lei, K. Wang, Int. J. Nanomed. 19 (2024) 699–707. doi: 10.2147/ijn.s415668
58. [58]
  Z.X. Wang, Y. Hou, W. Han, et al., Chem. Res. Chinese U. 27 (2011) 94–98.
59. [59]
  L. Gao, Y.Z. Fan, T.H. Zhang, et al., RSC Adv. 9 (2019) 11567–11575. doi: 10.1039/c9ra01029g
60. [60]
  H. Jiang, R. Wang, F. Zhou, et al., Int. J. Biol. Macromol. 211 (2022) 35–46.
61. [61]
  Y. Lang, X. Tian, H.Y. Dong, et al., Cells 11 (2022) 1651. doi: 10.3390/cells11101651
62. [62]
  B. Yang, Y. Chen, J. Shi, Adv. Mater. 31 (2019) 1901778.
63. [63]
  X. Qian, J. Zhang, Z. Gu, et al., Biomaterials 211 (2019) 1–13. doi: 10.1155/2019/7362931
64. [64]
  W. Cao, M. Jin, K. Yang, et al., J. Nanobiotechnol. 19 (2021) 325.
65. [65]
  C. Jia, Y. Guo, F.G. Wu, Small 18 (2022) 2103868.
66. [66]
  Q. Zhou, S. Shao, J. Wang, et al., Nat. Nanotechnol. 14 (2019) 799–809. doi: 10.1038/s41565-019-0485-z
67. [67]
  A. Zhang, K. Meng, Y. Liu, et al., Adv. Colloid Interface Sci. 284 (2020) 102261.
1. [1]
  Deshuai Zhen , Chunlin Liu , Qiuhui Deng , Shaoqi Zhang , Ningman Yuan , Le Li , Yu Liu . A review of covalent organic frameworks for metal ion fluorescence sensing. Chinese Chemical Letters, 2024, 35(8): 109249-. doi: 10.1016/j.cclet.2023.109249
2. [2]
  Yuanyi Zhou , Ke Ma , Jinfeng Liu , Zirun Zheng , Bo Hu , Yu Meng , Zhizhong Li , Mingshan Zhu . Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works. Chinese Chemical Letters, 2024, 35(6): 109056-. doi: 10.1016/j.cclet.2023.109056
3. [3]
  Hengrui Zhang , Xijun Xu , Xun-Lu Li , Xiangwen Gao . Applications of Generative Artificial Intelligence in Battery Research: Current Status and Prospects. Acta Physico-Chimica Sinica, 2025, 41(10): 100115-0. doi: 10.1016/j.actphy.2025.100115
4. [4]
  Yunzhe Zheng , Si Sun , Jiali Liu , Qingyu Zhao , Heng Zhang , Jing Zhang , Peng Zhou , Zhaokun Xiong , Chuan-Shu He , Bo Lai . Application of machine learning for material prediction and design in the environmental remediation. Chinese Chemical Letters, 2025, 36(9): 110722-. doi: 10.1016/j.cclet.2024.110722
5. [5]
  Di Wang , Qing-Song Chen , Yi-Ran Lin , Yun-Xin Hou , Wei Han , Juan Yang , Xin Li , Zhen-Hai Wen . Tuning strategies and electrolyzer design for Bi-based nanomaterials towards efficient CO2 reduction to formic acid. Chinese Journal of Structural Chemistry, 2024, 43(8): 100346-100346. doi: 10.1016/j.cjsc.2024.100346
6. [6]
  Jianju Li , Xinwei Chen , Yang Yu , Hao Ma , Xinhui Xia , Zixuan Zhao , Junqiu Jiang , Qingliang Zhao , Yingzi Lin , Liangliang Wei . Insights into bioavailable heavy metal impact driven by sludge application on soil nitrification: Toxicity thresholds and influential factors. Chinese Chemical Letters, 2025, 36(7): 110410-. doi: 10.1016/j.cclet.2024.110410
7. [7]
  Jingyi Yang , Sihan Wang , Xubiao Luo , Zhenyang Yu , Yanbo Zhou . Fenton-like process in antibiotic-containing wastewater treatment: Applications and toxicity evaluation. Chinese Chemical Letters, 2025, 36(12): 110996-. doi: 10.1016/j.cclet.2025.110996
8. [8]
  Baolei Li , Da Wang , Miao Yu , Chaozheng He , Xue Li , Jing Zhai , Mdmahadi Hasan , Chenxu Zhao , Min Wang , Dingcai Shen . Accelerating multi-objective catalytic material design: A model-based method. Chinese Chemical Letters, 2025, 36(12): 110454-. doi: 10.1016/j.cclet.2024.110454
9. [9]
  Lu Cheng , Jinghua Quan , Hongyan Li . Recent advances in antimony-based anode materials for potassium-ion batteries: Material selection, structural design and storage mechanisms. Chinese Chemical Letters, 2025, 36(9): 110685-. doi: 10.1016/j.cclet.2024.110685
10. [10]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619
11. [11]
  Takuya Tanaka , Rikuto Noda , Yuki Sawatari , Riki Iwai , Ben Zhong Tang , Gen-ichi Konishi . Viscosity responsiveness of excited-state dynamics in aggregated-induced emission luminogens. Chinese Chemical Letters, 2025, 36(12): 111495-. doi: 10.1016/j.cclet.2025.111495
12. [12]
  Yuxin Li , Chengbin Liu , Qiuju Li , Shun Mao . Fluorescence analysis of antibiotics and antibiotic-resistance genes in the environment: A mini review. Chinese Chemical Letters, 2024, 35(10): 109541-. doi: 10.1016/j.cclet.2024.109541
13. [13]
  Yimin Guo , Yiting Luo , Shuwen Hua , Chuan-Fan Ding , Yinghua Yan . Application of magnetic nanomaterials in peptidomics: A review in the past decade. Chinese Chemical Letters, 2025, 36(6): 110070-. doi: 10.1016/j.cclet.2024.110070
14. [14]
  Xinguo Mao , Shuo Zhang , Qiang Shi , Hua Cheng , Leyong Wang . Macrocyclic host molecules: Rising as a promising supramolecular material. Chinese Chemical Letters, 2025, 36(6): 110950-. doi: 10.1016/j.cclet.2025.110950
15. [15]
  Hanqing Zhang , Xiaoxia Wang , Chen Chen , Xianfeng Yang , Chungli Dong , Yucheng Huang , Xiaoliang Zhao , Dongjiang Yang . Selective CO2-to-formic acid electrochemical conversion by modulating electronic environment of copper phthalocyanine with defective graphene. Chinese Journal of Structural Chemistry, 2023, 42(10): 100089-100089. doi: 10.1016/j.cjsc.2023.100089
16. [16]
  Yuxiang Zhang , Jia Zhao , Sen Lin . Nitrogen doping retrofits the coordination environment of copper single-atom catalysts for deep CO2 reduction. Chinese Journal of Structural Chemistry, 2024, 43(11): 100415-100415. doi: 10.1016/j.cjsc.2024.100415
17. [17]
  Yao Wang , Jun Ouyang , Huadong Yuan , Jianmin Luo , Shihui Zou , Jianwei Nai , Xinyong Tao , Yujing Liu . Impact of local amorphous environment on the diffusion of sodium ions at the solid electrolyte interface in sodium-ion batteries. Chinese Chemical Letters, 2025, 36(10): 110412-. doi: 10.1016/j.cclet.2024.110412
18. [18]
  Zhenyang Lin . A classification scheme for inorganic cluster compounds based on their electronic structures and bonding characteristics. Chinese Journal of Structural Chemistry, 2024, 43(5): 100254-100254. doi: 10.1016/j.cjsc.2024.100254
19. [19]
  Yan Cheng , Hai-Quan Yao , Ya-Di Zhang , Chao Shi , Heng-Yun Ye , Na Wang . Nitrate-bridged hybrid organic-inorganic perovskites. Chinese Journal of Structural Chemistry, 2024, 43(9): 100358-100358. doi: 10.1016/j.cjsc.2024.100358
20. [20]
  Ningxiang Wu , Huaping Zhao , Yong Lei . Nanomaterials with highly ordered nanostructures: Definition, influence and future challenge. Chinese Journal of Structural Chemistry, 2024, 43(11): 100392-100392. doi: 10.1016/j.cjsc.2024.100392

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(20)
HTML views(6)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142