Citation: Chen Liu, Tianqi Zhao, Jialing Zhou, Xiaoyun Hu, Dinghao Pan, Jinlong Li, Wei Li, Zhihui Dai. Optical lateral flow immune assay technology for body fluid sensing[J]. Chinese Chemical Letters, ;2026, 37(1): 110967. doi: 10.1016/j.cclet.2025.110967 shu

Optical lateral flow immune assay technology for body fluid sensing

Chen Liu ^a ,
Tianqi Zhao ^a ,
Jialing Zhou ^a ,
Xiaoyun Hu ^a ,
Dinghao Pan ^a ,
Jinlong Li ^a ,
Wei Li ^{a, *,} ,
Zhihui Dai ^{a, b, *,}

a.
Jiangsu Provincial University Key Laboratory of Intelligent Medical Sensing Materials and Devices, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China
b.
School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China

liwei93@njtech.edu.cn

dzh@njtech.edu.cn

Received Date: 13 November 2024
Revised Date: 13 February 2025
Accepted Date: 17 February 2025
Available Online: 18 February 2025

Figures(10)

Detecting biomarkers in body fluids by optical lateral flow immune assay (LFIA) technology provides rapid access to disease information for early diagnosis. LFIA is based on an antigen-antibody reaction and is rapidly becoming the preferred choice of physicians and patients for point-of-care testing due to its simplicity, cost-effectiveness, and rapid detection. Observing the optical signal change from the colloidal gold of the traditional LFIA strip has been widely applied for various biomarkers detection in body fluids. Despite the significant progress, rapid real-time detection of color changes in the colloidal gold by the naked eye still faces many limitations, such as large errors and the inability to quantify and accurately detect. New optical LFIA strip technology has emerged in recent years to extend its application scenarios for achieving quantitative detection such as fluorescence, afterglow, and chemiluminescence. Herein, we summarized the development of optical LFIA technology from single to hyphenated optical signals for biomarkers detection in body fluids from invasive and non-invasive sources. Moreover, the challenge and outlook of optical LFIA strip technology are highlighted to inspire the designing of next-generation diagnostic platforms.
- Optical signal,
- Lateral flow immune assay,
- Hyphenated optical technology,
- Body fluid sensing,
- Point-of-care testing
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沈阳化工大学材料科学与工程学院沈阳 110142