Citation: Lei Li, Annan Liu, Gang Wei, Xingchen Li, Hao Liang, Maja D. Nešić, Ze Wang, Hui Guo, Quan Lin. Advanced nanosystem for target recognition and precise dual-mode imaging-guided photothermal therapy against triple-negative breast cancer[J]. Chinese Chemical Letters, ;2026, 37(2): 110961. doi: 10.1016/j.cclet.2025.110961 shu

Advanced nanosystem for target recognition and precise dual-mode imaging-guided photothermal therapy against triple-negative breast cancer

Lei Li ^{a, b} ,
Annan Liu ^a ,
Gang Wei ^c ,
Xingchen Li ^a ,
Hao Liang ^a ,
Maja D. Nešić ^d ,
Ze Wang ^{e, f, *,} ,
Hui Guo ^{b, *,} ,
Quan Lin ^{a, *,}

a.
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China
b.
Department of Endocrinology, Lequn Branch, The First Hospital of Jilin University, Changchun 130031, China
c.
Department of Breast Surgery, Jilin Cancer Hospital, Changchun 130012, China
d.
Center for Light-Based Research and Technologies COHERENCE, Department of Atomic Physics, Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, Belgrade 11000, Serbia
e.
Department of Hand Surgery, the Second Hospital of Jilin University, Changchun 130041, China
f.
Joint International Research Laboratory of Ageing Active Strategy and Bionic Health in Northeast Asia of Ministry of Education, Changchun 130041, China

zewang@jlu.edu.cn

ghui@jlu.edu.cn

linquan@jlu.edu.cn

Received Date: 27 November 2024
Revised Date: 13 February 2025
Accepted Date: 14 February 2025
Available Online: 15 February 2025

Figures(5)

Triple-negative breast cancer (TNBC) presents significant diagnostic and therapeutic challenges due to the lack of targeted treatments, rapid progression, high recurrence and metastasis rates, and overall poorer prognosis. Herein, the targeted theranostic platform of cysteine-modified gold nanodots-sulfhydrated luteinizing hormone releasing hormone (CGN-SLR) nanosystem was designed for target recognition and precise dual-mode imaging-guided photothermal therapy (PTT) against TNBC. On the one hand, the CGN-SLR nanosystem can serve as an ideal targeting fluorescent probe and computed tomography (CT) enhancer to facilitate the accurate diagnosis and surgical guidance of TNBC. On the other hand, the CGN-SLR nanosystem with great targeting and PTT ability can significantly inhibit the growth of TNBC, without causing harm to normal tissues and healthy organs. It provides an effective strategy for the diagnosis and treatment of TNBC through the rational design of multifunctional nanoplatform with target recognition, multiple imaging guidance/monitoring, and high-efficiency PTT.
- Nanodots,
- Triple-negative breast cancer,
- Tumor targeting,
- Imaging-guided,
- Photothermal therapy
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