Citation: Chenchen Xie, Jun Liao, Yi Li, Yunan Zhang, Zhicheng Xiao, Yun Wang, Ting Chen, Liyan Xiong, Tao Pang, Xiangao Jiang, Feng Zhang, Chuan Zhang, Tingfang Wang. Synergistic anti-inflammatory effect of cascade nanozymes for neural recovery in ischemic stroke[J]. Chinese Chemical Letters, ;2026, 37(1): 110956. doi: 10.1016/j.cclet.2025.110956 shu

Synergistic anti-inflammatory effect of cascade nanozymes for neural recovery in ischemic stroke

Chenchen Xie ^{a, 1} ,
Jun Liao ^{b, 1} ,
Yi Li ^{a, 1} ,
Yunan Zhang ^a ,
Zhicheng Xiao ^a ,
Yun Wang ^a ,
Ting Chen ^a ,
Liyan Xiong ^a ,
Tao Pang ^c ,
Xiangao Jiang ^d ,
Feng Zhang ^{c, *,} ,
Chuan Zhang ^{a, *,} ,
Tingfang Wang ^{a, *,}

a.
411 Hospital of Shanghai University, School of Medicine, Shanghai University, Shanghai 200444, China
b.
Beijing Key Laboratory of Tumor Systems Biology, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China
c.
Department of Pharmacy, Changzheng Hospital, Naval Medical University, Shanghai 200003, China
d.
Department of Infectious Disease, Wenzhou Central Hospital, Dingli Clinical College of Wenzhou Medical University, Wenzhou Sixth People's Hospital, Wenzhou 325000, China

fengzhang@smmu.edu.cn

zc843016@shu.edu.cn

wangtf66@shu.edu.cn

Received Date: 4 December 2024
Revised Date: 12 February 2025
Accepted Date: 13 February 2025
Available Online: 15 February 2025

Figures(4)

Overproduction of reactive oxygen species (ROS) following ischemic injury triggers an inflammatory response, significantly impeding neurological functional recovery. Nanozymes with potent antioxidative and anti-inflammatory effects thus offer great potential for ischemic stroke treatment. In this study, we developed an ischemia-homing nanozyme by combining melatonin (MT)-loaded honeycomb manganese dioxide (MnO₂) nanoflowers with M2-type microglia membranes to rescue the ischemic penumbra. The surface-engineered M2-type microglia membranes provided intrinsic ischemia-homing and blood-brain barrier (BBB)-crossing properties to the biomimetic nanozymes. This nanozyme can not only transforms harmfulsuperoxide anion radicals (^•O^2–) and hydrogen peroxide (H₂O₂) into harmless water and oxygen but also scavenges highly toxic hydroxyl radicals (^•OH), dramatically lowering intracellular ROS levels. More importantly, the biomimetic nanoparticles reduce cerebral infarct areas and provide significant neuroprotection against ischemic stroke by lowering oxidative stress, inhibiting cell apoptosis, and decreasing inflammation. This study may offer a viable approach for the use of nanozymes in treating ischemic stroke.
- Ischemic stroke,
- Nanozymes,
- Reactive oxygen species,
- Blood-brain barrier,
- Neuroprotection
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