Citation: Qingyu Niu, Yulu Zhang, Zerong Ge, Jiabao Liu, Zhiqiang Li, Yong Chen, Yu Liu. Competitive binding based on cucurbit[8]uril for florescence/phosphorescence ratiometric detection of 3-nitrotyrosine[J]. Chinese Chemical Letters, ;2025, 36(11): 110935. doi: 10.1016/j.cclet.2025.110935 shu

Competitive binding based on cucurbit[8]uril for florescence/phosphorescence ratiometric detection of 3-nitrotyrosine

Qingyu Niu ^{a, 1} ,
Yulu Zhang ^{b, 1} ,
Zerong Ge ^a ,
Jiabao Liu ^a ,
Zhiqiang Li ^{a, c, *,} ,
Yong Chen ^{b, **,} ,
Yu Liu ^{b, **,}

a.
School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, China
b.
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
c.
Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Nankai University, Tianjin 300071, China

^**

zhiqiangli@hebut.edu.cn

chenyong@nankai.edu.cn

yuliu@nankai.edu.cn

Received Date: 9 October 2024
Revised Date: 28 January 2025
Accepted Date: 6 February 2025
Available Online: 7 February 2025

Figures(5)

Purely organic room-temperature phosphorescence (RTP) and fluorescence dual-emission materials in aqueous solution have attracted growing attention. Herein, we report a fluorescence-phosphorescence dual emission host-guest complex by simple assembly of cucurbit[8]uril (CB[8]) and 4-(4-bromophenyl)pyridinium derivative in water. Macrocyclic confinement and unique 1:2 host-guest structure could effectively inhibit non-radiative transition of the guest and the quenching of water molecule, thus induce effective RTP emission in water (τ_RTP = 0.472 ms, Φ_RTP = 1.37%). Specifically, based on competitive binding, this host-guest complex exhibits rapid ratiometric luminescent detection behavior to 3-nitrotyrosine, a specific biomarker of kidney injury, with a low limit of detection of 10.7 nmol/L. This work highlights the great potential of macrocyclic-confinement-derived RTP materials in biomarker detection, and will undoubtedly broaden the utilization scope of RTP.
- Room-temperature phosphorescence,
- Macrocyclic confinement,
- Cucurbit[8]uril,
- Ratiometric detection
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