Citation: Chengying Wang, Bohan Chen, Yuming Wang, Bingyu Xie, Peishuang Yu, Xiaojie Xu, Rui Wang, Lin Miao, Xiaohui Yan, Yubo Li, Yunfei Li, Wei Huang. Advances of nanomedicine targeting the interface of cholesterol metabolism and immune evasion[J]. Chinese Chemical Letters, ;2025, 36(12): 110921. doi: 10.1016/j.cclet.2025.110921 shu

Advances of nanomedicine targeting the interface of cholesterol metabolism and immune evasion

Chengying Wang ^{a, 1} ,
Bohan Chen ^{b, 1} ,
Yuming Wang ^{a, 1} ,
Bingyu Xie ^e ,
Peishuang Yu ^a ,
Xiaojie Xu ^a ,
Rui Wang ^a ,
Lin Miao ^c ,
Xiaohui Yan ^c ,
Yubo Li ^{a, *,} ,
Yunfei Li ^{a, d, *,} ,
Wei Huang ^{b, *,}

a.
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
b.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
c.
State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
d.
Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao 266237, China
e.
Dongfang Zhenmei (Beijing) Technology Development Co., Ltd., Beijing 100070, China

yaowufenxi001@sina.com

liyunfei@tjutcm.edu.cn

huangwei@imm.ac.cn

Received Date: 19 November 2024
Revised Date: 29 January 2025
Accepted Date: 4 February 2025
Available Online: 6 February 2025

Figures(4)

Immune evasion is a hallmark of cancer. Recent advancements suggest that targeting cholesterol metabolism to regulate stimulator of interferon genes (STING) signaling offers a promising approach to overcome this challenge. While STING pathway activation is critical for enhancing anti-tumor immunity, its excessive or prolonged activation can lead to chronic inflammation and immune suppression. This review examines how cholesterol-lowering nanomedicines can balance STING activation to promote effective immune responses. Nanoparticles (NPs) enable precise delivery of cholesterol-lowering agents, reducing chronic STING activation and transforming the tumor microenvironment (TME) into an immunostimulatory state. Furthermore, NPs can co-deliver STING agonists to synergize innate immune activation, providing enhanced anti-tumor responses while mitigating the risks of inflammation. By integrating cholesterol metabolism modulation with advanced nanotechnologies, this approach holds significant translational potential for developing next-generation immunotherapies. Future research should focus on optimizing NP design and exploring combination strategies with existing cancer immunotherapies to improve clinical outcomes and address immune resistance.
- Cholesterol metabolism,
- STING pathway,
- Nanoparticle,
- STING agonist,
- Innate immunity
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沈阳化工大学材料科学与工程学院沈阳 110142