Citation: Jiao-Zhen Zhang, Cheng-Min Zhang, Yong-Jie Wang, Pei-Lin Wu, Rui-Feng Liu, Ye Li, Ming-Zhu Zhu, Shuang-Zhi Yuan, Ze-Jun Xu, Hong-Xiang Lou. Revision of the absolute configurations of Pallavicinia diterpenoids and further discovery of their Diels−Alder cycloadducts[J]. Chinese Chemical Letters, ;2026, 37(1): 110919. doi: 10.1016/j.cclet.2025.110919 shu

Revision of the absolute configurations of Pallavicinia diterpenoids and further discovery of their Diels−Alder cycloadducts

Jiao-Zhen Zhang ^{a, 1} ,
Cheng-Min Zhang ^{a, 1} ,
Yong-Jie Wang ^{a, b} ,
Pei-Lin Wu ^a ,
Rui-Feng Liu ^a ,
Ye Li ^b ,
Ming-Zhu Zhu ^a ,
Shuang-Zhi Yuan ^a ,
Ze-Jun Xu ^a ,
Hong-Xiang Lou ^{a, *,}

a.
Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Ji’nan 250012, China
b.
The Second Hospital, Shandong University, Ji’nan 250012, China

louhongxiang@sdu.edu.cn

Received Date: 3 November 2024
Revised Date: 31 January 2025
Accepted Date: 4 February 2025
Available Online: 6 February 2025

Figures(7)

Owing to their intricate molecular frameworks and copious chiral centers, the structural identification and configurational assignment of natural products are challenging tasks. Comprehensive spectral data analysis is crucial for the confirmation of absolute configurations. Ignoring critical parameters will lead to false structure, which may confuse the total synthesis and drug development. Herein, the configurations of seven heterogeneous Pallavicinia diterpenoids (PDs) isolated from Pallavicinia liverworts are revised using a combination of single-crystal X-ray diffraction and electronic circular dichroism (ECD) calculations. Meanwhile, identification of five unprecedented PD heterodimers PD-dimers A–E (18–22) along with eleven previously undescribed PDs (5–9, 13–17, 23) obtained by the reinvestigation of the Chinese liverwort Pallavicinia subciliata have resulted in corrections and support the revised conclusions.
- Revision,
- Absolute configurations,
- Pallavicinia diterpenoids,
- Liverwort,
- Single-crystal X-ray diffraction,
- Electronic circular dichroism calculations
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