Citation: Jing Feng, Yanhong Liu, Liming Gong, Chenfei Liu, Congcong Xiao, Liqing Chen, Mingji Jin, Zhonggao Gao, Wei Huang, Yubo Li. Recent progress on drug delivery systems of regulating intratumoral bacteria for tumor therapy[J]. Chinese Chemical Letters, ;2025, 36(11): 110907. doi: 10.1016/j.cclet.2025.110907 shu

Recent progress on drug delivery systems of regulating intratumoral bacteria for tumor therapy

Jing Feng ^{a, b} ,
Yanhong Liu ^c ,
Liming Gong ^{a, b} ,
Chenfei Liu ^{a, b} ,
Congcong Xiao ^{a, b} ,
Liqing Chen ^{a, b} ,
Mingji Jin ^{a, b} ,
Zhonggao Gao ^{a, b, *,} ,
Wei Huang ^{a, b, *,} ,
Yubo Li ^{d, *,}

a.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
b.
Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
c.
Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University, Suzhou 215000, China
d.
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China

gaozg@imm.ac.cn

huangwei@imm.ac.cn

yaowufenxi001@sina.com

Received Date: 10 November 2024
Revised Date: 26 January 2025
Accepted Date: 1 February 2025
Available Online: 2 February 2025

Figures(3)

Intratumoral bacteria have been proven to be widely exist in tumors, different tumors of different systems have different types of characteristic bacteria. Intratumoral bacteria will become a new and important biomarker in the full cycle of tumor development. This article emphasizes the key role of intratumoral bacteria in the occurrence and progress of tumors, including promoting tumor development, accelerating tumor metastasis and promoting tumor cell resistance. In addition, this article also summarizes the application of intratumoral bacteria in tumor diagnosis and prognosis. Especially, this article outlines the treatment strategies of intratumoral bacteria, including non-nanodelivery therapy strategies and nanodelivery therapy strategies, such as antibiotic, macromolecular, inflammatory factor inhibitors, near-infrared-photothermal therapy, inorganic antibacterial agents, reactive species and microbes therapy, in these strategies, nano delivery system provides a promising treatment that solves the problem of drug resistance, reducing toxicity and improving patient compliance. This article is hoped to guide future research on intratumoral bacteria on tumors.
- Intratumoral bacteria,
- Occurrence and progress,
- Diagnosis,
- Prognosis,
- Non-nanodelivery systems,
- Nanodelivery systems
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沈阳化工大学材料科学与工程学院沈阳 110142