Citation: Wei Zhou, Di He, Ning Liu, Ying Li, Wenzhao Han, Weiping Zhou, Siyu Zhang, Cong Yu. A PDI-based NIR-Ⅱ fluorescence imaging guided molecular phototheranostic platform for GSH-triggered gas therapy, mild photothermal therapy and NIR-activated photodynamic therapy[J]. Chinese Chemical Letters, ;2025, 36(11): 110854. doi: 10.1016/j.cclet.2025.110854 shu

A PDI-based NIR-Ⅱ fluorescence imaging guided molecular phototheranostic platform for GSH-triggered gas therapy, mild photothermal therapy and NIR-activated photodynamic therapy

Wei Zhou ^{a, b} ,
Di He ^a ,
Ning Liu ^a ,
Ying Li ^a ,
Wenzhao Han ^a ,
Weiping Zhou ^{a, b} ,
Siyu Zhang ^{a, b} ,
Cong Yu ^{a, b, *,}

a.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
University of Science and Technology of China, Hefei 230026, China

congyu@ciac.ac.cn

Received Date: 11 November 2024
Revised Date: 13 January 2025
Accepted Date: 14 January 2025
Available Online: 15 January 2025

Figures(7)

Synergistic therapy using multiple modalities is a highly promising therapeutic strategy. Near-infrared-Ⅱ (NIR-Ⅱ) fluorescence imaging, with its deep penetration and high fidelity, has frequently been employed in the literature to guide and assist treatment. Herein, we report the development of a NIR-Ⅱ fluorescence imaging guided multi-therapy platform PDI-DS NPs, which integrates a novel activatable phototheranostic agent PDI-DBU, a H₂S donor DPS and an amphiphilic polymer DSPE-mPEG2000. In order to maximize redshift of absorption and emission of PDI derivatives, we introduced an electron donating group DBU on PDI to obtain PDI-DBU. PDI-DBU exhibits a distinct absorption band at 700–900 nm and demonstrates excellent NIR-Ⅱ fluorescence emission/imaging properties and good photothermal effects under 808 nm laser irradiation. More importantly, under 808 nm laser irradiation, PDI-DBU could be oxidized, and the photodynamic effect of the material could be subsequently activated under 530 nm laser irradiation, achieving the combination of photothermal and activatable photodynamic dual modality treatment. The H₂S donor DPS, when triggered by the abundant glutathione (GSH) within the tumor microenvironment (TME), is capable of generating H₂S. On one hand, H₂S can inhibit tumor growth by disrupting mitochondrial function, on the other hand, it can also repress the expression of heat shock protein 90 (HSP90), thereby reversing tumor cell resistance mechanism against photothermal therapy. The utilization of PDI-DS NPs combined with DPS for efficient tumor ablation has been successfully demonstrated both in vitro and in vivo. This synergistic therapeutic platform thus offers a promising strategy in the field of NIR-Ⅱ fluorescence imaging guided tumor therapy.
- Perylene diimide probe,
- NIR-Ⅱ fluorescence,
- Imaging-guided therapy,
- Gas therapy,
- Photothermal therapy,
- NIR activated photodynamic therapy
1. [1]
  R. Siegel, K. Miller, A. Jemal, CA Cancer J. Clin. 69 (2019) 7–34. doi: 10.3322/caac.21551
2. [2]
  G. Wu, X. Wu, X. Zhu, J. Xu, N. Bao, ACS Nano 16 (2022) 10130–10155. doi: 10.1021/acsnano.2c02841
3. [3]
  M. Tan, Y. Xu, Z. Gao, et al., Adv. Mater. 34 (2022) 2108491. doi: 10.1002/adma.202108491
4. [4]
  C. Domingues, A. Santos, C. Alvarez-Lorenzo, et al., ACS Nano 16 (2022) 9994–10041. doi: 10.1021/acsnano.2c00128
5. [5]
  X. Han, C. Gong, Q. Yang, et al., Int. J. Nanomed. 19 (2024) 571–608. doi: 10.2147/ijn.s442877
6. [6]
  Y. Su, B. Liu, B. Wang, et al., Small 20 (2024) 2310342. doi: 10.1002/smll.202310342
7. [7]
  T. Hu, L. Jia, H. Li, et al., Adv. Healthc. Mater. 13 (2024) 2303147. doi: 10.1002/adhm.202303147
8. [8]
  X. Chu, P. Zhang, Y. Wang, et al., Carbon 176 (2021) 126–138. doi: 10.1016/j.carbon.2021.01.119
9. [9]
  X. Li, J. Chen, S. Liu, et al., ACS Appl. Nano Mater. 6 (2023) 17728–17739. doi: 10.1021/acsanm.3c03000
10. [10]
  J. Wang, P. Chen, Y. Dong, et al., Biomaterials 276 (2021) 121056. doi: 10.1016/j.biomaterials.2021.121056
11. [11]
  H. He, X. Zhang, L. Du, et al., Adv. Drug Deliv. Rev. 186 (2022) 114320. doi: 10.1016/j.addr.2022.114320
12. [12]
  H. He, L. Du, H. Xue, et al., Small Method. 7 (2023) 2300230. doi: 10.1002/smtd.202300230
13. [13]
  C. Li, Y. Cheng, D. Li, et al., Int. J. Mol. Sci. 23 (2022) 7909. doi: 10.3390/ijms23147909
14. [14]
  L. Lv, B. Fan, X. Ji, et al., Coord. Chem. Rev. 507 (2024) 215733. doi: 10.1016/j.ccr.2024.215733
15. [15]
  K. Yang, B. Yu, W. Liu, et al., Chin. Chem. Lett. 34 (2023) 107889. doi: 10.1016/j.cclet.2022.107889
16. [16]
  X. Lv, X. Ran, Y. Zhao, et al., Chin. Chem. Lett. 36 (2025) 110027. doi: 10.1016/j.cclet.2024.110027
17. [17]
  Y. Wang, S. Luo, Y. Wu, et al., ACS Nano 14 (2020) 17046–17062. doi: 10.1021/acsnano.0c06415
18. [18]
  C. Liu, S. Li, R. Ma, et al., Nano Today 42 (2022) 101363. doi: 10.1016/j.nantod.2021.101363
19. [19]
  L. Feng, D. Tao, Z. Dong, et al., Biomaterials 127 (2017) 13–24. doi: 10.1016/j.biomaterials.2016.11.027
20. [20]
  X. Chen, Z. Zhang, W. Luo, et al., Biomaterials 287 (2022) 121680. doi: 10.1016/j.biomaterials.2022.121680
21. [21]
  J. Miao, Y. Huo, G. Yao, et al., Angew. Chem. Int. Ed. 61 (2022) e202201815. doi: 10.1002/anie.202201815
22. [22]
  C. Zhao, W. Liu, W. Sun, et al., Anal. Chim. Acta 1231 (2022) 340198. doi: 10.1016/j.aca.2022.340198
23. [23]
  X. Min, F. Yi, X.L. Han, et al., Chem. Eng. J. 432 (2022) 134327. doi: 10.1016/j.cej.2021.134327
24. [24]
  G. Yang, C. Chen, Y. Zhu, et al., ACS Appl. Mater. Interfaces 11 (2019) 44961–44969. doi: 10.1021/acsami.9b15996
25. [25]
  J. Shen, D. Chen, Y. Liu, et al., J. Mater. Chem. B 9 (2021) 4826–4831. doi: 10.1039/d1tb00937k
26. [26]
  L. Hu, Y. Xu, Y. Zhao, et al., Chem. Eng. J. 476 (2023) 146829. doi: 10.1016/j.cej.2023.146829
27. [27]
  C. Wang, S. Lv, Z. Sun, et al., Aggregate 5 (2024) 587–600. doi: 10.1002/agt2.587
28. [28]
  Y. Yu, H. Wang, Z. Zhuang, et al., ACS Nano 18 (2024) 13019–13034. doi: 10.1021/acsnano.4c01600
29. [29]
  P. Ghaffari, H. Jafari, O. Okoro, et al., Small Method (2024) 2301349.
30. [30]
  Q. Wang, C. Zhang, Y. Zhao, et al., Biomaterials 309 (2024) 122606. doi: 10.1016/j.biomaterials.2024.122606
31. [31]
  S. Li, Z. Chen, W. Guo, et al., Adv. Funct. Mater. 34 (2024) 2314742. doi: 10.1002/adfm.202314742
32. [32]
  S. Wan, J. Zeng, H. Cheng, X. Zhang, Biomaterials 185 (2018) 51–62. doi: 10.1016/j.biomaterials.2018.09.004
33. [33]
  S. Liu, J. Ma, X. Xu, A. Wang, N. Zheng, Sci. China Chem. 67 (2024) 1624–1635. doi: 10.1007/s11426-023-1917-8
34. [34]
  S. Liu, C. Li, H. Lee, et al., Medicina 60 (2024) 245. doi: 10.3390/medicina60020245
35. [35]
  J. Cheng, Y. Zhu, Y. Dai, et al., Angew. Chem. Int. Ed. 62 (2023) e202304312. doi: 10.1002/anie.202304312
36. [36]
  X. Guo, J. Liu, L. Jiang, et al., J. Nanobiotechnol. 19 (2021) 321. doi: 10.1186/s12951-021-01042-9
37. [37]
  G. Wu, F. Liu, N. Li, et al., Adv. Sci. 10 (2023) 2304104. doi: 10.1002/advs.202304104
38. [38]
  X. Liang, M. Kurboniyon, Y. Zou, et al., Pharmaceutics 15 (2023) 2443. doi: 10.3390/pharmaceutics15102443
39. [39]
  Y. Su, B. Yu, S. Wang, H. Cong, Y. Shen, Biomaterials 271 (2021) 120717. doi: 10.1016/j.biomaterials.2021.120717
40. [40]
  J. Xu, A. Gulzar, P. Yang, et al., Coord. Chem. Rev. 381 (2019) 104–134. doi: 10.1016/j.ccr.2018.11.014
41. [41]
  J. Wang, Y. Liu, M. Morsch, et al., Adv. Mater. 34 (2021) 2106082.
42. [42]
  J. Xu, N. Zhu, Y. Du, et al., Nat. Commun. 15 (2024) 2845. doi: 10.1038/s41467-024-47063-4
43. [43]
  H. Dang, Y. Tian, Q. Cheng, et al., J. Colloid. Interface Sci. 612 (2022) 287–297. doi: 10.1016/j.jcis.2021.12.177
44. [44]
  J. Li, L. Xie, B. Li, et al., Adv. Mater. 33 (2021) 2008481. doi: 10.1002/adma.202008481
45. [45]
  W. Tang, Z. Yang, S. Wang, et al., ACS Nano 12 (2018) 2610–2622. doi: 10.1021/acsnano.7b08628
46. [46]
  P. Sun, P. Yuan, G. Wang, et al., Biomacromolecules 18 (2017) 3375–3386. doi: 10.1021/acs.biomac.7b01029
47. [47]
  Y. Ding, Z. Tong, L. Jin, et al., Adv. Mater. 34 (2022) 2106388. doi: 10.1002/adma.202106388
48. [48]
  Y. Cai, D. Ni, W. Cheng, et al., Angew. Chem. Int. Ed. 59 (2020) 14014–14018. doi: 10.1002/anie.202001107
49. [49]
  W. Zhou, D. He, K. Zhang, et al., Biosens. Bioelectron. 259 (2024) 116424. doi: 10.1016/j.bios.2024.116424
50. [50]
  X. Li, F. Fang, B. Sun, et al., Nanoscale Horiz. 6 (2021) 177–185. doi: 10.1039/d0nh00672f
51. [51]
  Y. Liu, P. Bhattarai, Z. Dai, X. Chen, Chem. Soc. Rev. 48 (2019) 2053–2108. doi: 10.1039/C8CS00618K
52. [52]
  C. Park, T. Ha, M. Kim, et al., Biosens. Bioelectron. 105 (2018) 151–158. doi: 10.1016/j.bios.2018.01.018
53. [53]
  T. Ubuka, J. Chromatogr. B 781 (2002) 227–249. doi: 10.1016/S1570-0232(02)00623-2
54. [54]
  X. He, S. Zhang, Y. Tian, W. Cheng, H. Jing, Int. J. Nanomed. 18 (2023) 1433–1468. doi: 10.2147/ijn.s405020
55. [55]
  T. Chou, Pharmacol. Rev. 58 (2006) 621–681. doi: 10.1124/pr.58.3.10
56. [56]
  Y. Hu, X. Li, Y. Fang, et al., Chem. Sci. 10 (2019) 7690–7694. doi: 10.1039/c9sc02323b
57. [57]
  K. Wang, Y. Li, X. Wang, et al., Nat. Commun. 14 (2023) 2950. doi: 10.1038/s41467-023-38601-7
58. [58]
  G. Ma, X. Zhang, K. Zhao, et al., ACS Nano 18 (2024) 3369–3381. doi: 10.1021/acsnano.3c10249
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