Citation: Jialin Guo, Mingrui Gu, Yahui Chen, Tao Xiong, Yiyang Zhang, Simin Chen, Mingle Li, Xiaoqiang Chen, Xiaojun Peng. Nucleic acid delivery by lipid nanoparticles for organ targeting[J]. Chinese Chemical Letters, ;2025, 36(11): 110849. doi: 10.1016/j.cclet.2025.110849 shu

Nucleic acid delivery by lipid nanoparticles for organ targeting

Jialin Guo ^a ,
Mingrui Gu ^a ,
Yahui Chen ^a ,
Tao Xiong ^a ,
Yiyang Zhang ^a ,
Simin Chen ^a ,
Mingle Li ^a ,
Xiaoqiang Chen ^{a, *,} ,
Xiaojun Peng ^{a, b, *,}

a.
State Key Laboratory of Fine Chemicals, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518071, China
b.
State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials, Dalian University of Technology, Dalian 116024, China

chenxq@szu.edu.cn

pengxj@dlut.edu.cn

Received Date: 18 October 2024
Revised Date: 10 January 2025
Accepted Date: 13 January 2025
Available Online: 13 January 2025

Figures(8)

The potential of messenger RNA (mRNA) as a therapeutic tool for treating diseases has garnered considerable interest, especially in the wake of the successful creation of mRNA vaccines to counter corona virus disease 2019 (COVID-19). Nucleic acid-based drug gene therapies have emerged as exceptionally promising avenues for combating disease. Furthermore, lipid nanoparticles (LNPs) are ideal carriers for nucleic acid delivery owing to their ionic nature, which enables nucleic acids to electrostatically interact with intracellular membranes, thereby promoting efficient intracellular nucleic acid release. Unfortunately, the effectiveness of LNPs in targeting organs beyond the liver is relatively poor. Thus, enhanced extrahepatic targeting is another important property that would lead to improved in vivo delivery by LNPs. This review focuses on the fundamental characteristics and functions of LNPs developed to facilitate cellular uptake and ensure effective intracellular release of mRNAs. Promising applications, possible advantages and potential challenges associated with use of LNPs in organ specific delivery and release of mRNAs are summarized. Furthermore, the need for future research to address limitations of currently developed LNPs for clinical applications of the mRNA technology is emphasized.
- Lipid nanoparticles (LNP),
- Nucleic acid delivery,
- Organ targeting,
- Liver targeting,
- Non-liver organ targeting
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沈阳化工大学材料科学与工程学院沈阳 110142