Citation: Zhijuan Niu, Peizhe Sun, Kwangnak Koh, Changping Li. Ultrasensitive electrochemical sensor based on para-sulfonatocalix[4]arene functionalized gold nanoparticles for sulfamethazine detection[J]. Chinese Chemical Letters, ;2025, 36(11): 110844. doi: 10.1016/j.cclet.2025.110844 shu

Ultrasensitive electrochemical sensor based on para-sulfonatocalix[4]arene functionalized gold nanoparticles for sulfamethazine detection

Zhijuan Niu ^{a, b} ,
Peizhe Sun ^b ,
Kwangnak Koh ^c ,
Changping Li ^{a, *,}

a.
Research Center for Eco-Environmental Engineering, Dongguan University of Technology, Dongguan 523808, China
b.
School of Environmental Science and Engineering, Tianjin University, Tianjin 300072, China
c.
Institute of Liberal Education, Pusan National University, Busan 46241, Republic of Korea

licpbit@hotmail.com

Received Date: 17 December 2024
Revised Date: 9 January 2025
Accepted Date: 10 January 2025
Available Online: 15 January 2025

Figures(4)

In order to realize the simple and rapid detection of antibiotic contaminants in environmental water, the para-sulfocalix[4]arene (pSC₄) functionalized gold nanoparticles (AuNPs) composites (pSC₄-AuNPs) were prepared by sodium borohydride reduction. Here, a rapid and sensitive electrochemical sensor for the detection of antibiotic contaminants in water was constructed. The detection mechanism and the signaling changes of the different sulfamethazine (SMZ) concentrations were further explored based on pSC₄-AuNPs/SMZ modified glassy carbon electrode through aggregation of gold nanoparticles induced by host-guest recognition of SMZ and pSC₄. The results suggested that this method achieved rapid and ultrasensitive detection of SMZ with a limit of detection of 0.0038 ng/mL (linear detection range of 1.0 - 1.0 × 10⁴ ng/mL). The recoveries ranged from 91.1% to 97.0% with relative standard deviations (RSDs) of 1.5%-3.5%. The accurate detection of SMZ in recovery rate of spiking assay proved the potential practical application of the sensor. Host-guest recognition induced AuNPs aggregation results in dramatic signal enhancement for electrochemical impedimetric detection assay of SMZ. This detection method provides a new concept for developing sensitive electrochemical sensors for simple and sensitive detection of small molecules in water.
- Electrochemical detection,
- Gold nano-nanoparticles,
- para-Sulfocalix[4]arene,
- Host-guest interaction,
- Sulfamethazine
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沈阳化工大学材料科学与工程学院沈阳 110142